Magnetic nanoparticle imaging method and system based on non-uniform excitation field

Abstract

The invention belongs to the technical field of biomedical imaging, and specifically relates to a magnetic nanoparticle imaging method and system based on a non-uniform excitation field, aiming to solve the problem that the existing technology cannot overcome the limitation of uniform magnetic field excitation, so that the field of view of magnetic nanoparticle imaging is small, A problem with limited scope of application. The invention includes: separating the non-uniform excitation magnetic field into independent space and current-time functions through the time-space separation method; calculating the normalized signal peak value through the current-time function; constructing a reconstruction mathematical model based on the normalized signal peak value and the volume of the imaging subunit; Combining the normalized signal peak value, the non-uniform spatial function of the excitation magnetic field and the reconstruction mathematical model, the spatial distribution of nanoparticles is quantitatively reconstructed, and the magnetic nanoparticle imaging of the object to be reconstructed is realized. The invention can reduce the artifact error caused by the non-uniform excitation magnetic field, effectively improve the precision and resolution of the image, has low power consumption, low maintenance cost, and convenient and simple implementation process.

Description

technical field [0001] The invention belongs to the technical field of biomedical imaging, and in particular relates to a magnetic nanoparticle imaging method and system based on a non-uniform excitation field. Background technique [0002] Magnetic nanoparticles are nanoscale particles with superparamagnetic properties. In recent years, they have been widely studied and applied as a new type of medical imaging tracer in clinical problems such as tumor detection, magnetic particle hyperthermia, and targeted drug delivery. . [0003] The magnetic nanoparticle imaging (MPI) method is to control the gradient magnetic field with high field strength to encode the entire imaging field of view, and at the same time apply a high-frequency uniform excitation magnetic field to excite the magnetic nanoparticles to generate a nonlinear response, and finally use the response voltage detected by the receiving coil The signal is imaged. Traditional magnetic nanoparticle imaging uses a un...

AI Technical Summary

Problems solved by technology

[0007] In order to solve the above-mentioned problems in the prior art, that is, the prior art cannot overcome the limitation of uniform magnetic field excitation, so that the magnetic nanoparticle imaging field of view is small and the application range is limited, the present invention provides a magnetic field based on non-uniform excitation field A nanoparticle imaging method, the method comprising:

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