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Application of flavonol derivatives in the preparation of anti-chlamydia infection drugs

A technology of flavonoid alcohols and chlamydia, which is applied in the field of medicine, can solve the problems of no biological activity and low content of dihydroflavonoids, and achieve the effects of wide application, good anti-chlamydia proliferation activity, and good anti-chlamydia infection activity

Active Publication Date: 2022-07-26
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of dihydroflavonoids with complex rearrangements in the B ring is extremely low in nature, and there are no reports on their biological activities at the same time

Method used

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  • Application of flavonol derivatives in the preparation of anti-chlamydia infection drugs
  • Application of flavonol derivatives in the preparation of anti-chlamydia infection drugs
  • Application of flavonol derivatives in the preparation of anti-chlamydia infection drugs

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Embodiment 1

[0023] Embodiment 1, structural formula is the preparation of formula I compound

[0024] The present invention adopts the steps of extraction and purification under normal conditions under laboratory culture conditions to prepare the compounds of the present invention. The plant used is the fresh pine leaves of Yunnan pine (Pinusyunnanensis Franch).

[0025] The process of specific compounds is as follows: 1) Extraction

[0026] The fresh pine leaves (5.2kg) of P. yunnanensis were collected, dried in the shade, pulverized, extracted with absolute ethanol at room temperature (5L*3), and the extract was concentrated to dryness under reduced pressure to obtain about 1071.8g of transformant residue.

[0027] 2) Reversed-phase silica gel column purification

[0028] The obtained residue was dissolved in an appropriate amount of methanol, applied to a chromatographic column filled with 120 g of reversed-phase silica gel (120 angstroms, 30-50 mesh), and eluted with a methanol-wate...

Embodiment 2

[0035] Example 2: Anti-Chlamydia Activity of Compound I of the Invention

[0036] (1) Experimental materials

[0037] Instruments and reagents: carbon dioxide incubator; microplate reader (Bio-TEKELx800); fluorescence inverted microscope (Olympus IX51); RPMI 1640 medium (Gibcol BRL), RnaseA, fetal bovine serum, dimethyl sulfoxide (DMSO), Trypsin (Shanghai Bioengineering Co., Ltd.), HeLa / Hep2 cells. The pathogenic Chlamydia strains used in the test: Chlamydia trachomatis (Ct), Chlamydia pneumoniae (Cpn), and Chlamydia muridarum Nigg (MoPn) were purchased from the Institute of Microbiology, Chinese Academy of Medical Sciences.

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Abstract

The invention belongs to the technical field of medicine preparation, and discloses the application of a flavonol derivative in the preparation of an anti-chlamydia infection medicine. The flavonol derivatives provided by the invention have good anti-chlamydia proliferation effect on plant growth, can be used for preparing anti-chlamydia infection medicines, and have good medicinal uses as active components of anti-chlamydia infection medicines.

Description

technical field [0001] The invention relates to the field of medicine, and relates to the application of a flavonol derivative in the preparation of an anti-Chlamydia infection drug, in particular to the application of a dihydroflavonol derivative in the preparation of an anti-Chlamydia infection drug. Background technique [0002] Chlamydia is a prokaryotic gram-negative pathogen with a unique biphasic developmental cycle and strictly parasitic in eukaryotic cells, which can infect any animal and cause a variety of diseases. The main pathogenic Chlamydia include Chlamydia trachomatis, Chlamydia pneumoniae and Chlamydia psittaci. Genital Chlamydia trachomatis infection is one of the most common sexually transmitted diseases worldwide. According to reports, there are about 130 million new infections of genital Chlamydia trachomatis every year, which has risen to the first place in sexually transmitted diseases. When Chlamydia trachomatis invades the human body, it can induc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61P31/04A61K36/15C07D311/32C07D311/40A61K127/00
CPCA61K31/353A61P31/04A61K36/15C07D311/32C07D311/40
Inventor 李建林刘迪宋妍王安东杨敏
Owner NANTONG UNIVERSITY
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