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Application of composition containing astilbin and/or isomer thereof to preparation of medicine for treating psoriasis

A technology of astilbin and isoastilbin, which is applied in the direction of medical preparations containing active ingredients, drug combinations, active ingredients of hydroxyl compounds, etc., can solve problems such as synergistic effects that have not been seen yet, and achieve stable and reliable drug quality Controlling, optimizing the combination ratio, and controlling the production quality have targeted effects

Pending Publication Date: 2021-12-21
广州白云山敬修堂药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching the literature, there is no relevant research report on the combination of astilbin and polyphenols for the treatment of psoriasis and the synergistic effect

Method used

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  • Application of composition containing astilbin and/or isomer thereof to preparation of medicine for treating psoriasis
  • Application of composition containing astilbin and/or isomer thereof to preparation of medicine for treating psoriasis
  • Application of composition containing astilbin and/or isomer thereof to preparation of medicine for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] 15g of astilbin, 3g of astilbin; 75g of microcrystalline cellulose; 50mL of 95% ethanol; 15g of hydroxypropyl cellulose; 120mL of 25% starch slurry; Mesh sieve granules, compressed into tablets.

Embodiment 2

[0079] 15g astilbin, 3g astilbin, 3g resveratrol; 75g microcrystalline cellulose; 50mL 95% ethanol; 15g hydroxypropyl cellulose; 120mL 20% starch slurry; 5g magnesium stearate, granulate, 50℃ Vacuum-dried, sieved with 60-100 mesh for granulation, and filled with capsules.

Embodiment 3

[0081] 15g astilbin, 5g isoastilbin, 3g astilagin, 3g resveratrol; 20g dextrin; 10g lactose, 120mL 25% starch slurry; 20g powdered sugar; Mesh sieve whole grains, pack into bags.

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Abstract

The invention belongs to the field of natural medicines, and particularly relates to a pharmaceutical composition of astilbin and / or isomer thereof for treating psoriasis as well as a preparation and application of the pharmaceutical composition. The pharmaceutical composition further comprises polyphenol selected from one or more of engeletin or isomer thereof, taxifolin, naringenin, quercetin and resveratrol. The pharmaceutical composition has a remarkable treatment effect on an imiquimod-induced psoriasis-like mouse model and a mouse tail scale model, in the pharmaceutical composition, the astilbin and / or the isomer thereof and the polyphenol are combined to have a remarkable synergistic effect, and the effect of the pharmaceutical composition is superior to that of single use of the astilbin; and the pharmaceutical composition is safe and free of adverse reaction, has a wide application prospect in preparation of the medicine for treating psoriasis, and has important social benefits and economic benefits.

Description

technical field [0001] The invention belongs to the field of natural medicines, and in particular relates to a pharmaceutical composition for treating psoriasis containing astilbin and / or its isomers, as well as its preparation and application. Background technique [0002] Psoriasis (Psoriasis), commonly known as psoriasis, is a clinically common chronic, relapsing, inflammatory autoimmune skin disease mediated by T cells. The clinical manifestations are mainly erythema and hypertrophic white scales of different shapes and sizes on the skin, mostly on the limbs, head and back. Severe skin lesions can spread to the skin of the whole body, and high fever, pustules, and erythroderma appear Psoriasis is characterized by lymphocyte infiltration, abnormal proliferation of keratinocytes, and abnormal secretion of cytokines as the main pathological manifestations. Psoriasis is affected by many factors such as age, gender, race, geographical location, environment, etc. The prevalen...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P17/06A61P29/00A61K31/05A61K31/352
CPCA61K31/7048A61P17/06A61P29/00A61K31/05A61K31/352A61K2300/00
Inventor 汤迎湛江涛曾利杰曾晨张陆勇刘菊妍马赛妍陈启明苏锐辉陈丽斯王川易彭红英
Owner 广州白云山敬修堂药业股份有限公司
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