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Micro-ecological microcapsule coated preparation and preparation method thereof

A microbial agent and micro-ecological technology, applied in the direction of bacteria, animal feed, additional food elements used in food preparation, etc., can solve the problems such as the inability to continue to function effectively, the production of metabolites is small, and the growth and reproduction speed is slow. , to achieve the effect of being conducive to clinical promotion and use, the production of metabolites is large, and the growth and reproduction speed is fast.

Pending Publication Date: 2021-12-28
山东迅达康兽药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, Bifidobacterium animalis, Lactobacillus casei and Brady's yeast are all used in animals, but on the whole, they have several deficiencies: first, there is no synergistic effect between bacteria and bacteria, and when entering the gastrointestinal tract The growth and reproduction speed after the passage is slow, and the amount of metabolites produced is less, resulting in no obvious effect; second, the three kinds of bacteria are separately fermented and produced, and the amount of bacteria is not high, and then compounded into products, the production cost is high, which is not conducive to popularization; Third, after long-term storage at room temperature, feed granulation, and digestion of gastric juice, pancreatic juice, bile, etc., the three bacteria have lost more and cannot continue to function effectively.

Method used

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  • Micro-ecological microcapsule coated preparation and preparation method thereof
  • Micro-ecological microcapsule coated preparation and preparation method thereof
  • Micro-ecological microcapsule coated preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Preparation of probiotics:

[0051] (1) Preparation of seed solution

[0052] Inoculate Bifidobacterium animalis into TPY liquid medium and culture anaerobically at 37°C for 18h to obtain Bifidobacterium animalis seed liquid; Inoculate Lactobacillus casei into MRS liquid medium and culture it at 37°C for 24h , to obtain Lactobacillus casei seed liquid; inoculate Brady's yeast into YPD liquid medium, and culture at 28° C. for 40 hours to obtain Brady's yeast seed liquid. The seed liquids of the above three bacteria were all placed in the refrigerator for later use.

[0053] (2) Preparation of mixed medium

[0054] 2.0 parts by weight of soybean peptone, 0.4 parts by weight of corn steep liquor dry powder, 2.0 parts by weight of glucose, 0.2 parts by weight of soluble starch, K 2 HPO 4 ·3H 2 O 0.1 parts by weight, MgSO 4 0.01 parts by weight, 0.2 parts by weight of L-cysteine, 0.1 parts by weight of Tween 800.1 parts by weight, 994.99 parts by weight of purified wa...

Embodiment 2

[0062] Preparation of microecological microcapsule coating preparation:

[0063] Add 0.2 parts by weight of cellulose acetate phthalate (CAP), 0.2 parts by weight of polyvinyl alcohol phthalate (PVAP), 15 parts by weight of skimmed milk powder and 4.0 parts by weight of sodium alginate to step (5) of Example 1 to prepare 80.6 parts by weight of the fermented liquid are mixed evenly, frozen or coated and dried to form a microecological microcapsule coating preparation.

Embodiment 3

[0064] Embodiment 3 tolerance test to digestive juice

[0065] Test the tolerance of the microecological microcapsule coating preparation prepared in Example 2 to the digestive juice, take the probiotic agent (Example 1) as a control, and use the survival rate of the three bacteria as tolerance indicators.

[0066] Digestive juice is replaced by artificial gastric juice and artificial intestinal juice.

[0067] Artificial gastric juice: Take 16.4mL of dilute hydrochloric acid, add about 800mL of water and 10g of pepsin (3000NFU / g, Suleibao Company), stir well, add water to make up to 1000mL.

[0068] Artificial intestinal juice: Take 6.8g of potassium dihydrogen phosphate and add 500mL of water, adjust the pH to 6.8 with 0.4% sodium hydroxide solution; take another 10g of pancreatin (250NFU / g, Suleibao Company) and add appropriate amount of water to dissolve, mix the two liquids After that, add water to make up to 1000mL.

[0069] Add the bacterial powder sample into artific...

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Abstract

The invention discloses a micro-ecological microcapsule coated preparation and a preparation method thereof, and belongs to the technical field of feed additives. The micro-ecological microcapsule coated preparation comprises live bacteria of animal bifidobacterium, lactobacillus casei and Brady's yeast, and metabolites of the three bacteria. The micro-ecological microcapsule coated preparation disclosed by the invention can effectively avoid the loss of bacteria after feed granulation, digestion of gastric juice, pancreatic juice, bile and the like and long-term storage at normal temperature, plays an effective role, and prolongs the shelf life.

Description

technical field [0001] The invention belongs to the technical field of feed additives, and in particular relates to a microecological microcapsule coating preparation and a preparation method thereof. Background technique [0002] The microbial ecosystem in the animal body is composed of countless bacteria, viruses, fungi and other microorganisms. Various beneficial bacteria and harmful bacteria play different roles on the animal body in a delicate balance state, and a healthy and balanced body The microecology is not only beneficial to the metabolism and absorption of nutrients of animals, but also allows animals to radiate more vitality and become healthier and more lively. Therefore, proper supplementation of probiotics is the most direct way to keep the animal microecology alive. [0003] When the gastrointestinal tract of animals is infected by pathogens, antibiotics are usually used for treatment, and the disease can be controlled in a short period of time at first, b...

Claims

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Application Information

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IPC IPC(8): A23K10/18
CPCA23K10/18A23K10/12A23K20/163A23K20/147A23K10/30A23K20/26A23K20/142A23K20/121A23K40/30A23K10/20A23K20/105A23K50/42A23K50/75A23K50/30C12N1/20C12N1/16A23V2400/125A23V2400/515
Inventor 汪安国田玉虎李凤华
Owner 山东迅达康兽药有限公司