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Vanillylmandelic acid derivative, synthesis method therefor, vanillylmandelic acid immunogen, preparation method therefor and application of vanillylmandelic acid immunogen
InactiveCN107353200AHigh sensitivityStrong specificitySerum immunoglobulinsOrganic compound preparationMandelic acidBiochemistry
The invention discloses a vanillylmandelic acid derivative, a synthesis method therefor, a vanillylmandelic acid immunogen, a preparation method therefor and an application of the vanillylmandelic acid immunogen. A specific vanillylmandelic acid antibody prepared from the vanillylmandelic acid derivative is high in specificity and high in potency and is free of any cross reaction with 92 kinds of common interferents, so that relatively high accuracy, precision, sensitivity and specificity can be embodied; and the application of the vanillylmandelic acid immunogen means applying the vanillylmandelic acid immunogen to the preparation of the specific vanillylmandelic acid antibody and applying the specific vanillylmandelic acid antibody to the preparation of a vanillylmandelic acid detection reagent, and the detection reagent can be used for achieving high-throughput and rapid detection of vanillylmandelic acid on a fully-automatic biochemical analyzer.
Owner:苏州博源医疗科技有限公司
Phosphatidylinositol proteoglycan GPC3 protein fragment, application thereof and hybridoma cell strain prepared therewith
ActiveCN104829704AStrong antibody specificityIncrease productionTissue cultureBiological testingProtein detectionAmino acid
The invention relates to a phosphatidylinositol proteoglycan GPC3 protein fragment, which has an amino acid sequence represented as the SEQ ID NO.1. The GPC3 protein fragment is strong in antibody specificity, can be used for preparing a polyclonal or monoclonal antibody being high in titer or preparing a GPC3 protein standard sample, and can be used in GPC3 protein detection, comprising detections of the content, the activity and the structure. The invention also relates to a monoclonal antibody hybridoma cell strain GPC3-1H5. A GPC3 antibody secreted from the GPC3-1H5 is high in yield and titer and is sensitive in reaction, so that the GPC3 antibody can improve sensitivity and accuracy of detection. The GPC3-1H5 can be widely applied in the detection of expression of the GPC3, can reduce the production cost of the GPC3 and is beneficial to clinical popularization and application of GPC3 detection.
Owner:BIOLOGY INST OF HEBEI ACAD OF SCI
Lipoprotein phospholipase A2 detection reagent and preparation and usage method thereof
ActiveCN109917131AReduce testing costsStrong specificityOvalbuminSerum albuminPhospholipase A2Fully automatic
The invention relates to a lipoprotein phospholipase A2 detection reagent and a preparation and usage method thereof. The detection reagent can be used to automatically determine a lipoprotein phospholipase A2 content on a fully-automatic biochemical analyzer. The lipoprotein phospholipase A2 content in a biological sample can be rapidly and accurately determined in a high-throughput mode. The reagent and the method have advantages of simple operation, high sensitivity, good specificity, an accurate result and the like. Lipoprotein phospholipase A2 detection cost is effectively reduced, and the reagent and the method are good for clinical wide popularization and usage.
Owner:苏州博源医疗科技有限公司
Imatinib immunogen, derivative, synthesis method, specific antibody and detection reagent and preparation methods
ActiveCN104804079AReduce testing costsStrong specificityCompound screeningApoptosis detectionSynthesis methodsImatinib
The invention discloses an imatinib immunogen, derivative, synthesis method, specific antibody and detection reagent and preparation methods. The imatinib immunogen prepared by the invention is high in immunogenicity, can be induced to obtain a high-titer anti-imatinib specific antibody and does not crossly react with sixty-two common drugs; the imatinib detection reagent prepared by using the antibody can accurately and quickly determine the content of imatinib in samples. Compared with the existing detection reagent in the market, the detection reagent disclosed by the invention has the advantages of simplicity and convenience in operation, high sensitivity, high specificity, accurate result and the like, the imatinib detection cost can be effectively reduced and the large-scale clinical popularization and use are facilitated.
Owner:长沙博源医疗科技有限公司
Estriol homogeneous phase enzyme immunoassay reagent as well as preparation method and detection method thereof
ActiveCN106645692AImprove throughputStrong specificityBiological material analysisEstriolEnzyme immunoassays
The invention discloses an estriol homogeneous phase enzyme immunoassay reagent as well as a preparation method and a detection method thereof and belongs to the technical field of immunoassay reagents. An estriol immunogen prepared by the invention is high in immunogenicity, can be induced to obtain a high-titer anti-estriol specific antibody and does not have any cross reaction with 62 common drugs. The estriol immunoassay reagent prepared by the antibody is capable of accurately and rapidly determining the estriol content in biological samples such as urea, blood and the like. Compared with the existing assay reagents in the market as well as detection methods and preparation methods thereof, the detection reagent disclosed by the invention has the advantages of simplicity and convenience in operation, high sensitivity, high specificity, accurate result and the like, is capable of effectively reducing the estriol detection cost and is favorable for large-scale clinical popularization and application.
Owner:苏州博源医疗科技有限公司
Matrix metalloproteinase-3(MMP3) detection kit
InactiveCN105974105AThe measurement result is accurateHigh detection sensitivityMaterial analysisAntigenLatex particle
The invention relates to a matrix metalloproteinase-3(MMP3) detection kit and a detection method thereof, and belongs to the technical field of medical and biological detection. The kit comprises a first reagent, a second reagent, a calibrator and a quality control product, wherein the first reagent comprises Tris-HCl, sodium azide, and PEG-6000, and the second reagent comprises Tris-HCl, anti-human matrix metalloproteinase-3 antibody coated latex particles, sodium azide and methyl paraben. The calibrator comprises a matrix metalloproteinase-3 antigen and sodium azide, and the quality control product comprises a matrix metalloproteinase-3 antigen and sodium azide. The matrix metalloproteinase-3(MMP3) detection kit and the detection method thereof provided by the invention adopt a latex immune turbidimetric technology, has the advantages of high analytical sensitivity, accurate results, simple operation, suitable cost and the like, and is convenient for popularization.
Owner:河北艾驰生物科技有限公司
5-fluorouracil derivatives, 5-fluorouracil immunogens, antibodies for immunogens and 5-fluorouracil detection kit
InactiveCN104478813AImprove throughputReduce testing costsSerum albuminPeptide preparation methodsHigh fluxTrue positive rate
The invention provides 5-fluorouracil derivatives, 5-fluorouracil immunogens, antibody for the immunogens, and a 5-fluorouracil detection kit. The 5-fluorouracil derivatives provided by the invention have a structure shown in a formula (I) as shown in the specification, wherein R is -(CH2)n-COO- and n is an integer between 1 and 20. The 5-fluorouracil derivatives with the structural formula are combined with a specific carrier, so that the prepared 5-fluorouracil immunogens have high immunogenicity; and the antibodies generated by an animal immunized with the immunogens have relatively high sensitivity and specificity, and have high specific combining ability with 5-fluorouracil. Through use of a homogeneous enzyme immune detection technology, high-flux and fast detection of 5-fluorouracil by an full automatic biochemical analyzer can be achieved; and the detection is convenient to operate, high in sensitivity, high in specificity, accurate in result and the like; the 5-fluorouracil detection cost can be effectively reduced; and clinical promotion and application are facilitated.
Owner:苏州博源医疗科技有限公司
Serum amyloid a (saa) assay kit
ActiveCN106053862BThe measurement result is accurateHigh detection sensitivityMaterial analysis by observing effect on chemical indicatorBiological testingAssayA Antibody
The invention relates to a serum amyloid protein A (SAA) measuring kit, and a measuring method thereof, and belongs to the technical field of medicine biological detection. The kit comprises a reagent (1), a reagent (2), a calibration material, and a quality control material. The reagent (1) comprises Tris-HCl, sodium azide, and PEG-6000. The reagent (2) comprises Tris-HCl, emulsion particles with an embedded anti-human serum amyloid protein A antibody, sodium azide, octyl phenol polyoxyethylene, and methyl paraben. The calibration material comprises a serum amyloid protein A antigen, and sodium azide. The quality control material comprises a serum amyloid protein A antigen, and sodium azide. The provided serum amyloid protein A (SAA) measuring kit and measuring method thereof have the advantages that compared with the latex immunological turbidimetry technology, the analysis sensitivity is high, the results are accurate, the operation is simple, and the cost is proper, and thus the method is convenient for popularization.
Owner:河北艾驰生物科技有限公司
11-dehydro thromboxane B2 homogeneous enzyme immunoassay kit and preparation method thereof
InactiveCN111443203ASimple and fast operationHigh sensitivityBiological testingMolecular biologyVitro diagnostics
The invention belongs to the technical field of in vitro diagnosis, and specifically provides an 11-dehydro thromboxane B2 homogeneous enzyme immunoassay kit. The invention is characterized by measuring 11-dehydro thromboxane B2 with the homogeneous enzyme immunoassay, and high-throughput rapid quantitative determination of 11-dehydro thromboxane B2 in human urine in a fully automatic biochemicalanalyzer is realized. The invention also includes an enzyme-labeled conjugate used in the kit and a preparation method thereof. Compared with the existing detection kits on the market, the kit of theinvention has the advantages such as high automation degree of the detection process, high sensitivity, high specificity and accurate results. The detection cost of 11-dehydro thromboxane B2 is also greatly reduced, and large-scale clinical popularization is facilitated.
Owner:深圳市安帝宝科技有限公司
Serum amyloid protein A (SAA) measuring kit
ActiveCN106053862AThe measurement result is accurateHigh detection sensitivityMaterial analysis by observing effect on chemical indicatorBiological testingTurbidimetrySerum amyloid protein
The invention relates to a serum amyloid protein A (SAA) measuring kit, and a measuring method thereof, and belongs to the technical field of medicine biological detection. The kit comprises a reagent (1), a reagent (2), a calibration material, and a quality control material. The reagent (1) comprises Tris-HCl, sodium azide, and PEG-6000. The reagent (2) comprises Tris-HCl, emulsion particles with an embedded anti-human serum amyloid protein A antibody, sodium azide, octyl phenol polyoxyethylene, and methyl paraben. The calibration material comprises a serum amyloid protein A antigen, and sodium azide. The quality control material comprises a serum amyloid protein A antigen, and sodium azide. The provided serum amyloid protein A (SAA) measuring kit and measuring method thereof have the advantages that compared with the latex immunological turbidimetry technology, the analysis sensitivity is high, the results are accurate, the operation is simple, and the cost is proper, and thus the method is convenient for popularization.
Owner:河北艾驰生物科技有限公司
Myeloperoxidase detection reagent and preparation and use method thereof
The invention relates to a myeloperoxidase detection reagent and a preparation and use method thereof. The automatic determination of the myeloperoxidase content on a full-automatic biochemical analyzer can be realized by applying the detection reagent, the myeloperoxidase content in a biological sample can be quickly and precisely determined in high flux, and the detection reagent has the advantages of being simple in operation, high in sensitivity, strong in specificity, and accurate in result. the myeloperoxidase detection cost can be effectively reduced, and the detection reagent is in favor of clinical and extensive popularization and use.
Owner:苏州博源医疗科技有限公司
Creatinine derivative, creatinine immunogen and specific antibody as well as creatinine detection kit
ActiveCN104557722AAccurately determine creatinine levelsDetermining creatinine contentSerum albuminDepsipeptidesCreatinine riseEnzyme immunoassays
The invention provides a creatinine derivative, a creatinine immunogen and a specific antibody as well as a creatinine detection kit. The creatinine derivative has a structure represented by the formula (I) as shown in the description, wherein R is -(CH2)n-COO- and n is an integer from 1 to 20. The creatinine immunogen, which is obtained by linking the creatinine derivative of which H on the specific site is substituted by R and which has the above formula and a specific carrier, has high immunogenicity, the antibody produced by immunizing and inducing animals is high in specificity and has strong specific binding capability with the creatinine; the high-throughput and rapid detection of creatinine can be achieved by virtue of a homogeneous enzyme immunoassay technology on a full-automatic biochemistry analyzer, the method has the advantages of high sensitivity, strong specificity and accurate results and is simple and convenient to operate, the creatinine detection cost can be effectively decreased and the method is conductive to clinical popularization and application.
Owner:苏州博源医疗科技有限公司
Elemene externally-applied preparation and its use
An exterior-applied elemene medicine with slow release and low irritation is proportionally prepared from elemene, organic solvent, medicinal matrix, and the additive chosen from hyaluronic acid, sodium hyaluronate gel, hyaluronidase, carbomer, and chitin. Its preparing process is also disclosed.
Owner:谢瑞钢
Oxcarbazepine derivative, immunogen, anti-oxcarbazepine specific antibody as well as preparation method and application of oxcarbazepine specific antibody
PendingCN114671809AImproving immunogenicityHigh sensitivitySerum immunoglobulinsSerum albuminAntiendomysial antibodiesEnzyme immunoassays
The invention discloses an oxcarbazepine derivative, an immunogen, an anti-oxcarbazepine specific antibody as well as a preparation method and application of the oxcarbazepine specific antibody. Firstly, a novel oxcarbazepine derivative and recombinant human serum albumin obtained through genetic engineering modification are coupled to prepare an oxcarbazepine artificial antigen, then the oxcarbazepine artificial antigen is used for immunizing an experimental animal to obtain an anti-oxcarbazepine specific antibody, and ELISA detection shows that the specific antibody is high in specificity and sensitivity and can be used for preparing the oxcarbazepine specific antibody. An interference experiment shows that the specific antibody does not have any cross reaction with 100 common drugs; the anti-oxcarbazepine specific antibody is applied to preparation of an oxcarbazepine detection reagent, the oxcarbazepine detection reagent comprises an oxcarbazepine average phase enzyme immunoassay reagent and an oxcarbazepine latex enhanced immunoturbidimetry detection reagent, and the detection reagent can realize high-flux and rapid detection of oxcarbazepine on a full-automatic biochemical analyzer.
Owner:长沙博源医疗科技有限公司
Preparation method of glue adhesion amnion
InactiveCN100479867CGood biocompatibilityHigh bonding strengthProsthesisEpitheliumBiological dressing
Owner:CHONGQING MEDICAL UNIVERSITY
Base-free wrought wire orthodontic retainer
The invention discloses a base-free wrought wire orthodontic retainer which comprises a dental arch wire around the dental buccal and tongue sides of first to seventh teeth. An occlusion across steel wire is welded between the sixth tooth and the seventh tooth; an occlusion across steel wire is welded between the fifth tooth and the sixth tooth; an occlusion across steel wire is welded between the third tooth and the fourth tooth; and the dental arch wire is divided into a front dental section and a rear dental section. The rear dental section is divided into retention arms and allopathic arms which are specifically distributed in a manner that the buccal side of the seventh tooth is provided with the retention arms, and the tongue side of the seventh tooth is provided with the allopathic arm; both sides of the sixth tooth are provided with the retention arms; the buccal side of the fifth tooth is provided with the allopathic arm, and the tongue side of the fifth tooth is provided with the retention arm; the buccal side of the fourth tooth is provided with the retention arm, and the tongue side of the fourth tooth is provided with the allopathic arm; and dental arch wires of the lip and tongue sides of the first, second and third teeth are arranged in the front dental section. The base-free wrought wire orthodontic retainer is not provided with a base, is comfortable to wear and easy to clean, does not cause adverse effects on the temporomandibular joint and periodontium, and allows the upper and lower teeth to be naturally occluded when being worn, thus being favorable to clinical popularization and application.
Owner:SHANDONG UNIV
Sensitive blood return indwelling needle
InactiveCN101306222ARelieve painReduce work intensityGuide needlesInfusion needlesEngineeringUltimate tensile strength
The invention relates to a sensitive blood returning remaining needle, which comprises a steel needle, a flexible tube, a clockwise device, a soft sealing body and an outer casing body, wherein, a sensitive blood returning device is installed at the rear part of the outer casing body, the rear end of the flexible tube is inserted and installed at the front end of the outer casing body, the clockwise device ensures that the rear end of the flexible tube is tightly clamped and fixed with the inner wall of the outer casing body, the flexible sealing body is fixedly installed in the outer casing body, the steel needle penetrates the flexible sealing body, the front half section thereof is inserted and installed in the flexible tube, to expose the point of the steel needle, and the tail part of the steel needle is connected with the sensitive blood returning device; the sensitive blood returning device is composed of a gasbag external supporting part, a gasbag and a gasbag internal supporting part, the opening of the gasbag is supported by the gasbag internal supporting part, the gasbag and the gasbag internal supporting part are installed in the external supporting part together, and are tightly clamped and fixed. The sensitive blood returning remaining needle has the advantages that the blood returning condition can be judged quickly during the transfusion process by medical care personnel, to reduce the work strength, and relieve the pain of patients; the operation of the product is convenient, and is favorable for being promoted and used during the clinical work; the structure and the manufacturing process are simple, the cost is low, and the sensitive blood returning remaining needle has very wide market prospect.
Owner:王慧美
Lamotrigine derivative, preparation method thereof and application of lamotrigine derivative in homogeneous enzyme immunoassay reagent
ActiveCN110967481AAvoid wastingImprove detection accuracyMaterial analysisAgainst vector-borne diseasesAntiendomysial antibodiesEnzyme immunoassays
The invention belongs to the technical field of biological detection, and particularly relates to a lamotrigine derivative, a preparation method thereof and application of the lamotrigine derivative in homogeneous enzyme immunoassay reagents. The structural formula of the lamotrigine derivative is shown as the following formula (I). The lamotrigine immunogen with high immunogenicity, a corresponding antibody, a lamotrigine enzyme-labeled conjugate and a lamotrigine homogeneous enzyme immunoassay reagent are obtained by using the compound shown as the formula (I). The lamotrigine immunogen is strong in specificity and high in immunogenicity; the prepared anti-lamotrigine antibody is strong in specificity and high in titer; the prepared homogeneous enzyme immunoassay reagent can rapidly andaccurately determine the content of lamotrigine in a biological sample, can simultaneously determine a plurality of samples on a full-automatic biochemical analyzer, realizes high-flux and rapid determination of lamotrigine, has high accuracy and strong specificity, and has greatly improved precision and detection efficiency compared with the prior art.
Owner:长沙博源医疗科技有限公司
Base-free wrought wire orthodontic retainer
Owner:SHANDONG UNIV
Olanzapine derivative, immunogen, anti-olanzapine specific antibody and preparation method and application thereof
PendingCN114685527AImproving immunogenicityHigh sensitivitySerum immunoglobulinsSerum albuminAntiendomysial antibodiesEnzyme immunoassays
The invention discloses an olanzapine derivative, an immunogen, an anti-olanzapine specific antibody as well as a preparation method and application of the olanzapine specific antibody. Firstly, a novel olanzapine derivative and recombinant sheep serum albumin obtained through genetic engineering modification are coupled to prepare an olanzapine artificial antigen, then the olanzapine artificial antigen is used for immunizing an experimental animal to obtain an anti-olanzapine specific antibody, and ELISA detection shows that the specific antibody is high in specificity and sensitivity and can be used for preparing the olanzapine specific antibody. An interference experiment shows that the specific antibody does not have any cross reaction with 100 common drugs; the anti-olanzapine specific antibody is applied to preparation of olanzapine detection reagents, the olanzapine detection reagents comprise an olanzapine average phase enzyme immunoassay reagent and an olanzapine latex enhanced immunoturbidimetry detection reagent, and the detection reagents can realize high-flux and rapid detection of olanzapine on a full-automatic biochemical analyzer.
Owner:长沙博源医疗科技有限公司
Vanilla mandelic acid homogeneous enzyme immunodetection reagent based on brominated derivative and preparation method of vanillic mandelic acid homogeneous enzyme immunodetection reagent
PendingCN114354938AStrong specificityHigh sensitivitySerum immunoglobulinsOrganic compound preparationAntiendomysial antibodiesMetabolite
The invention relates to a vanillylmandelic acid homogeneous enzyme immunodetection reagent based on brominated derivatives and a preparation method thereof. The vanilla mandelic acid brominated derivative and the synthetic method are specifically and newly researched and designed, and the vanilla mandelic acid brominated derivative immunogen is prepared from the newly researched and developed vanilla mandelic acid brominated derivative. An anti-vanillylmandelic acid specific antibody prepared by immunizing an experimental animal with the vanillylmandelic acid brominated derivative immunogen has no cross reaction with 30 common hormones and hormone metabolites. The detection sensitivity of a vanillylmandelic acid homogeneous enzyme immunodetection reagent based on a brominated derivative prepared from the anti-vanillylmandelic acid specific antibody and a vanillylmandelic acid brominated derivative enzyme-labeled conjugate reaches ng / mL level, and the concentration of trace vanillylmandelic acid in a biological sample can be accurately detected; the detection accuracy, precision, sensitivity and specificity are obviously higher than those in the prior art.
Owner:苏州博源医疗科技有限公司
Safety clean syringe
InactiveCN1814316AProtect the safety of useProtection from stabbing hazardsInfusion syringesIntravenous devicesEngineeringSyringe needle
This invention relates to a safe clean one-off injector, it includes injector coat, core bar set in the coat, rubber piston connected to forward end of the bar, and the pinhead set at forward end of the coat. A protecting jacket is muff coupled to the coat, the backward is a beaded edge extend outward, the jacket can slide on the coat. The pin can be destroyed after pulled into the jacket, so the safety of patient, medical care personnel and environment can be efficiently protected. Its using habit is same to the personnel using habit and operation is simple. It is propitious to clinical using and can be mass produced by using existing equipment.
Owner:耿世保
Diagnosis molecular marker circRNA, kit and application of idiopathic optic neuritis
ActiveCN111733227BImprove stabilityNot easy to degradeMicrobiological testing/measurementDNA/RNA fragmentationAbnormal expressionRetrobulbar optic nerve
The invention relates to the field of biological detection, in particular to circRNA, a kit and application of a diagnostic molecular marker for idiopathic optic neuritis. The present invention adopts circRNA chip detection to obtain abnormally expressed cerebrospinal fluid circRNAs expression profile, and uses qRT-PCR method for verification, and has strict design and mature evaluation system. It is the first time to discover hsa_circ_0007503 in cerebrospinal fluid as an important biological detection index. The detection index is minimally invasive and cheap, and can be widely used in clinical detection to solve the problems of long clinical diagnosis time, cumbersome process, high cost and low sensitivity of idiopathic optic neuritis . It provides new ideas for the diagnosis of idiopathic optic neuritis, and at the same time provides a new direction for improving the pathogenesis and therapeutic targets of idiopathic optic neuritis.
Owner:THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
A shoulder measuring ruler specially used for dentistry
The present invention discloses a special dental shoulder measurement rule, which comprises a handle, two connection arms and two measurement heads, wherein the two connection arms are respectively connected on both ends of the handle, the connection manner is a pin shaft type moveable joint connection, the two measurement heads are respectively connected with the ends of the two connection arms, the connection manner is a ball recessing type moveable joint connection, and the end of the measurement head is provided with scales. According to the present invention, the special dental shoulder measurement rule can be provided for measuring the shoulder width after tooth preparation in the narrow oral cavity space from various direction and various positions so as to further refine mouth rehabilitation, wherein the use effect is better by matching with a dental magnifier; and the special dental shoulder measurement rule has characteristics of low cost, easy use and easy disinfection and sterilization, easy achievement of clinical promotion use, and easy achievement of oral clinical medicine teaching.
Owner:SHANDONG UNIV
Circular RNA marker hsa_circ_0001788 and its application
ActiveCN109295218BImprove stabilityNot easy to degradeMicrobiological testing/measurementDNA/RNA fragmentationDiseaseSerum markers
The invention establishes a circRNA expression profile for a patient with craniosynostosis, provides, provides serum circRNA marker hsa_circ_0001788 for the patient with craniosynostosis, discloses diagnostic value of hsa_circ_0001788 of serum for craniosynostosis, applies the marker herein to prepare a diagnostic kit for the patient with craniosynostosis, and provides supporting for clinical early discovery and treatment of the patient with craniosynostosis. Serum circRNA has good stability, degradation difficulty and the other advantage, has high value in auxiliary diagnosis, and is easy toclinically popularize and use. A circRNA chip is used herein to carry out detecting to obtain disease-specific and abnormally-expressed serum circRNA expression profiles; verifying is performed by means of qRT-PCR; a strict design and evaluation system is provided. It is discovered for the first time that the marker hsa_circ_0001788 in serum is an important biological detection index which causesminimal invasion and has low cost and which is applicable to clinical detection; the marker hsa_circ_0001788 is important to the clinical early diagnosis and differential diagnosis of craniosynostosis; a new idea is provided for the diagnosis of craniosynostosis in molecular level, and it is expected that early diagnostic rate of craniosynostosis is increased.
Owner:NANJING MEDICAL UNIV
Aripiprazole key group derivative, immunogen, anti-aripiprazole specific antibody and preparation method and application thereof
PendingCN114685400AImproving immunogenicityHigh sensitivitySerum immunoglobulinsSerum albuminAntiendomysial antibodiesEnzyme immunoassays
The invention discloses an aripiprazole key group derivative, an immunogen, an anti-aripiprazole specific antibody and a preparation method and application thereof. Firstly, a novel aripiprazole key group derivative and recombinant human serum albumin obtained through genetic engineering modification are coupled to prepare an aripiprazole artificial antigen, then the aripiprazole artificial antigen is used for immunizing an experimental animal to obtain an anti-aripiprazole specific antibody, and ELISA detection shows that the specific antibody is high in specificity and sensitivity and can be used for preparing the aripiprazole specific antibody. An interference experiment shows that the specific antibody does not have any cross reaction with 100 common drugs; the anti-aripiprazole specific antibody is applied to preparation of aripiprazole detection reagents, the aripiprazole detection reagents comprise an aripiprazole homogeneous enzyme immunoassay reagent and an aripiprazole latex enhanced immunoturbidimetry detection reagent, and the detection reagents can realize high-flux and rapid detection of aripiprazole on a full-automatic biochemical analyzer.
Owner:长沙博源医疗科技有限公司
Creatinine derivatives, creatinine immunogens and their specific antibodies, and creatinine detection kits
ActiveCN104557722BAccurately determine creatinine levelsDetermining creatinine contentSerum albuminDepsipeptidesCreatinine riseEnzyme immunoassays
The invention provides a creatinine derivative, a creatinine immunogen and a specific antibody as well as a creatinine detection kit. The creatinine derivative has a structure represented by the formula (I) as shown in the description, wherein R is -(CH2)n-COO- and n is an integer from 1 to 20. The creatinine immunogen, which is obtained by linking the creatinine derivative of which H on the specific site is substituted by R and which has the above formula and a specific carrier, has high immunogenicity, the antibody produced by immunizing and inducing animals is high in specificity and has strong specific binding capability with the creatinine; the high-throughput and rapid detection of creatinine can be achieved by virtue of a homogeneous enzyme immunoassay technology on a full-automatic biochemistry analyzer, the method has the advantages of high sensitivity, strong specificity and accurate results and is simple and convenient to operate, the creatinine detection cost can be effectively decreased and the method is conductive to clinical popularization and application.
Owner:苏州博源医疗科技有限公司
Topiramate derivative, immunogen, anti-topiramate specific antibody and preparation method and application thereof
PendingCN114685526AImproving immunogenicityHigh sensitivitySerum immunoglobulinsSerum albuminAntiendomysial antibodiesEnzyme immunoassays
The invention discloses a topiramate derivative, an immunogen, an anti-topiramate specific antibody and a preparation method and application thereof. Firstly, a novel topiramate derivative and recombinant camel serum albumin obtained through genetic engineering modification are coupled to prepare a topiramate artificial antigen, then the topiramate artificial antigen is used for immunizing an experimental animal to obtain the anti-topiramate specific antibody, and ELISA detection shows that the specific antibody is high in specificity and sensitivity, and can be used for preparing the anti-topiramate specific antibody. An interference experiment shows that the specific antibody does not have any cross reaction with 100 common drugs; the anti-topiramate specific antibody is applied to preparation of a topiramate detection reagent, the topiramate detection reagent comprises a topiramate homogeneous enzyme immunoassay reagent and a topiramate latex enhanced immunoturbidimetry detection reagent, and the detection reagent can realize high-flux and rapid detection of topiramate on a full-automatic biochemical analyzer.
Owner:长沙博源医疗科技有限公司
Metanephrine derivative, immunogen, anti-metanephrine specific antibody and preparation method and application thereof
ActiveCN112266330AStrong specificityHigh sensitivityOrganic compound preparationSerum albuminAntiendomysial antibodiesEnzyme immunoassays
The invention discloses a metanephrine derivative, an immunogen, an anti-metanephrine specific antibody as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, coupling a novel metanephrine derivative with recombinant bovine serum albumin obtained by genetic engineering modification to prepare a metanephrine artificial antigen, and then immunizing an experimental animal with the metanephrine artificial antigen to obtain an anti-metanephrine specific antibody. ELISA detection shows that the specific antibody is strong in specificity and high in sensitivity, and an interference experiment shows that the specific antibody has no cross reaction with 32 common hormones; and the anti-metanephrine specific antibody is applied to preparation of metanephrine detection reagents, including a metanephrine homogeneous enzyme immunoassay reagent and a metanephrine latex enhanced turbidimetric immunoassay reagent. The detection reagent can realize high-throughput and rapid detection of metanephrine on a full-automatic biochemical analyzer.
Owner:长沙博源医疗科技有限公司
A kind of rabeprazole sodium preparation for injection and preparation method thereof
ActiveCN105853377BImprove stabilityEase of mass productionAntibacterial agentsPowder deliveryHydrogenArginine
Owner:WUHAN LEADPHARM TECH CO LTD
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