33results about How to "Conducive to clinical promotion and use" patented technology

The invention relates to an adhesive amniotic membrane, which is a double layer or multi-layer adhesive amniotic membrane bonded with amniotic membrane and fibrin albumen glue. The preparing method comprises: bonding the fresh amniotic membrane of epithelium removed with fresh amniotic membrane without removing epithelium by using fibrin albumen glue; or condensing the amniotic membrane immersing in the glycerol, and then bonding the fresh amniotic membrane of epithelium removed with fresh amniotic membrane without removing epithelium by using fibrin albumen glue; or bonding with the fresh amniotic membrane without removing epithelium by using fibrin albumen glue; finally putting the bonded adhesive amniotic membrane into pure glycerol under 0-6 Deg C for closed and sterile conservation. The product not only maintains the biological property and various biological activity of the amniotic membrane, but also the increases the clinical treating effect distinctively. The preparing process id simple and economical, the conservation time is as long as one year and with a high biological safety, which is facilitate for clinical spead. The product can be widely used in tissue engineering rebuilding and restoring, traumatology department, ulcerative tissue restoring, burn, scald biological dressing, plastics for eye rebuilding operation, and etc.

The invention discloses a base-free wrought wire orthodontic retainer which comprises a dental arch wire around the dental buccal and tongue sides of first to seventh teeth. An occlusion across steel wire is welded between the sixth tooth and the seventh tooth; an occlusion across steel wire is welded between the fifth tooth and the sixth tooth; an occlusion across steel wire is welded between the third tooth and the fourth tooth; and the dental arch wire is divided into a front dental section and a rear dental section. The rear dental section is divided into retention arms and allopathic arms which are specifically distributed in a manner that the buccal side of the seventh tooth is provided with the retention arms, and the tongue side of the seventh tooth is provided with the allopathic arm; both sides of the sixth tooth are provided with the retention arms; the buccal side of the fifth tooth is provided with the allopathic arm, and the tongue side of the fifth tooth is provided with the retention arm; the buccal side of the fourth tooth is provided with the retention arm, and the tongue side of the fourth tooth is provided with the allopathic arm; and dental arch wires of the lip and tongue sides of the first, second and third teeth are arranged in the front dental section. The base-free wrought wire orthodontic retainer is not provided with a base, is comfortable to wear and easy to clean, does not cause adverse effects on the temporomandibular joint and periodontium, and allows the upper and lower teeth to be naturally occluded when being worn, thus being favorable to clinical popularization and application.

The invention establishes a circRNA expression profile for a patient with craniosynostosis, provides, provides serum circRNA marker hsa_circ_0001788 for the patient with craniosynostosis, discloses diagnostic value of hsa_circ_0001788 of serum for craniosynostosis, applies the marker herein to prepare a diagnostic kit for the patient with craniosynostosis, and provides supporting for clinical early discovery and treatment of the patient with craniosynostosis. Serum circRNA has good stability, degradation difficulty and the other advantage, has high value in auxiliary diagnosis, and is easy toclinically popularize and use. A circRNA chip is used herein to carry out detecting to obtain disease-specific and abnormally-expressed serum circRNA expression profiles; verifying is performed by means of qRT-PCR; a strict design and evaluation system is provided. It is discovered for the first time that the marker hsa_circ_0001788 in serum is an important biological detection index which causesminimal invasion and has low cost and which is applicable to clinical detection; the marker hsa_circ_0001788 is important to the clinical early diagnosis and differential diagnosis of craniosynostosis; a new idea is provided for the diagnosis of craniosynostosis in molecular level, and it is expected that early diagnostic rate of craniosynostosis is increased.

The invention provides a creatinine derivative, a creatinine immunogen and a specific antibody as well as a creatinine detection kit. The creatinine derivative has a structure represented by the formula (I) as shown in the description, wherein R is -(CH2)n-COO- and n is an integer from 1 to 20. The creatinine immunogen, which is obtained by linking the creatinine derivative of which H on the specific site is substituted by R and which has the above formula and a specific carrier, has high immunogenicity, the antibody produced by immunizing and inducing animals is high in specificity and has strong specific binding capability with the creatinine; the high-throughput and rapid detection of creatinine can be achieved by virtue of a homogeneous enzyme immunoassay technology on a full-automatic biochemistry analyzer, the method has the advantages of high sensitivity, strong specificity and accurate results and is simple and convenient to operate, the creatinine detection cost can be effectively decreased and the method is conductive to clinical popularization and application.

The invention discloses a sodium rabeprazole preparation for injection and a preparing method thereof. The sodium rabeprazole preparation for the injection is prepared from the following components in parts by weight: 20 parts of sodium rabeprazole, 40-60 parts of mannitol, 1-10 parts of arginine and 0.5-4 parts of alkaline pH (potential of Hydrogen) regulators. The sodium rabeprazole preparation for the injection and the preparing method thereof adopt the arginine as a stabilizer, can improve the stability of a solution after the sodium rabeprazole and 0.9% sodium chloride injection liquid are composited; further, the clinical usage safety of the sodium rabeprazole preparation for the injection is improved. The sodium rabeprazole preparation for the injection and the preparing method thereof are beneficial to the clinical popularization and usage of sodium rabeprazole for the injection.