The invention belongs to the technical field of organic synthesis and discloses a 1,6-eneyne compound and alcohol compound based free radical cyclization reaction method. The method includes steps: taking an alcohol compound as a starting raw material, subjecting to cyclization reaction with a 1,6-eneyne compound under the action of an oxidant, and after complete reaction, performing aftertreatment to obtain a cyclization product namely a 2-pyrrolidone compound. The method has advantages that raw materials are cheap, easy to acquire, extensive in source, stable and low in toxicity, consumptionof any transition metal catalysts and ligands is avoided, the reaction can be carried out in an air atmosphere and is mild in condition and easy in operation, the product is free of heavy metal residues, and the method has advantages of extensive reaction substrate applicable range, simple, efficient, economical and green and is suitable for industrial production. In addition, an economical, practical, green and environmental-friendly novel idea is provided for alcohol free radical cyclization, and an application range is expanded.