An apparatus for establishing a re-usable, recurring, mechanical connection to an organ within a patient is provided. A subcutaneous needle connection system for providing bidirectional, straight and turbulent-free fluid flow access to a vascular system of a patient includes a housing defining a needle access opening for receiving a needle, a cannula opening in communication with the vascular system and a passageway connecting the needle access opening to the cannula opening. The housing can additionally have a second needle access opening connected to a second cannula opening via a second passageway. The subcutaneous needle connection system allows for blood to be removed from the vascular system via one cannula opening, passed to a hemodialysis system via a needle inserted in an associated needle access opening, treated using the hemodialysis system, and returned to the vascular system via the other needle access opening and associated cannula opening. The implantable needle connection system provides enhanced mechanical stability under the skin, improved fluid flow dynamics, improved needle hole healing potential of the skin, and improved needle edge interfacing to minimize flow turbulence and blood cell trauma during use.