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A kind of binuclear cadmium complex and its preparation method and application

A cadmium complex and complex technology, applied in cadmium organic compounds, chemical instruments and methods, fluorescence/phosphorescence, etc., can solve problems such as short half-life and deviation of detection results

Active Publication Date: 2022-03-08
四川省产品质量监督检验检测院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The detection of nitric oxide is an important test item when conducting inspections, but due to its short half-life and rapid diffusion characteristics, the test results will be biased

Method used

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  • A kind of binuclear cadmium complex and its preparation method and application
  • A kind of binuclear cadmium complex and its preparation method and application
  • A kind of binuclear cadmium complex and its preparation method and application

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preparation example Construction

[0042] The present invention also provides a preparation method for the binuclear cadmium complex, comprising the following steps:

[0043] (1) mixing substituted phenol, lead acetate and dehydrated alcohol to obtain a mixed solution;

[0044] (2) After mixing the mixed solution with an anhydrous ethanol solution of N,N-bis(3-aminopropyl)-2-pyridinemethanamine, a coordination condensation reaction is carried out to obtain a lead complex;

[0045] (3) carry out displacement reaction after mixing the anhydrous methanol solution of lead complex and cadmium sulfate, obtain described binuclear cadmium complex;

[0046] The substituted phenol is 2,6-diformyl-4-methylphenol, 2,6-diformyl-4-methoxyphenol, 2,6-diformyl-4-fluorophenol, 2,6 - Diformyl-4-chlorophenol or 2,6-diformyl-4-bromophenol.

[0047] In the present invention, the lead acetate in the step (1) is preferably lead acetate tetrahydrate.

[0048] In the present invention, the molar ratio of substituted phenol and lead ...

Embodiment 1

[0077] Mix 0.5mmol of 2,6-diformyl-4-methylphenol, 0.5mmol of lead acetate tetrahydrate and 15mL of absolute ethanol and stir at 300rpm for 2h to obtain a mixed solution; The 10mL absolute ethanol solution of (3-aminopropyl)-2-pyridylmethylamine is added dropwise in the mixed solution at the speed of 3 drops / second, and after the dropwise addition, the solution turns from bright yellow turbidity to a yellow transparent solution, at 300rpm Stirring at a rotating speed of 100°C for the coordination condensation reaction, the lead complex was obtained after 3 hours; then the 3CdSO containing 0.167mmol 4 ·8H 2 O 15mL absolute ethanol solution was added dropwise at a rate of 3 drops / second to the lead complex. After the dropwise addition, the solution turned yellow and turbid. Stir at a speed of 300rpm to carry out the displacement reaction. After stirring for 4 hours, use a sand core to filter; Wash the obtained lead sulfate precipitate with 15 mL of anhydrous methanol, combine t...

Embodiment 2

[0100] Mix 0.4mmol of 2,6-diformyl-4-chlorophenol, 0.6mmol of lead acetate tetrahydrate and 10mL of absolute ethanol and stir at 200rpm for 1.8h to obtain a mixed solution; The 12mL absolute ethanol solution of (3-aminopropyl)-2-pyridinemethanamine is added dropwise in the mixed solution at the speed of 3 drops / second, after the dropwise addition, the solution turns from bright yellow turbidity to a yellow transparent solution, at 200rpm Stirring at the rotating speed of 2.5h to carry out the coordination condensation reaction, the lead complex is obtained after 2.5h; then the 3CdSO containing 0.15mmol 4 ·8H 2 Add 20mL of absolute ethanol solution of O to the lead complex dropwise at a rate of 3 drops / second. After the dropwise addition, the solution turns yellow and turbid. Stir at a speed of 200rpm for displacement reaction. After stirring for 3.5h, use a sand core to filter ; The obtained lead sulfate precipitate is washed with 10 mL of anhydrous methanol, and the filtrate...

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Abstract

The invention belongs to the technical field of synthetic compounds. The invention provides a kind of binuclear cadmium complex. The invention uses substituted phenol and N,N-bis(3-aminopropyl)-2-pyridylmethylamine as raw materials, and uses lead ions with a large coordination number as a template to carry out The lead complex was obtained through the coordination condensation reaction; the lead complex was mixed with cadmium sulfate, and the lead ions in the complex were replaced to obtain a binuclear cadmium complex. The replaced lead ions formed lead sulfate precipitates, which facilitated subsequent filtration and separation . The preparation method provided by the invention is simple, the core steps are coordination condensation reaction and displacement reaction, and the target complex can be prepared efficiently. It is verified by experiments that the binuclear cadmium complex and nitric oxide prepared by the invention can form a stable complex with a low detection limit, and can be used to prepare nitric oxide fluorescent probe products.

Description

technical field [0001] The invention relates to the technical field of synthetic compounds, in particular to a binuclear cadmium complex and a preparation method and application thereof. Background technique [0002] Nitric oxide is widely distributed in various tissues in organisms, especially in nerve tissues, and is a new type of biological messenger molecule. Nitric oxide is an extremely unstable biological free radical with a small molecular structure and a simple structure. It is a gas at room temperature. It is slightly soluble in water and has fat solubility. It can quickly diffuse through biological membranes. The biological half-life of nitric oxide is only 3-5s. Its production depends on nitric oxide synthase, and it plays a very important biological role in heart, cerebrovascular regulation, nerve and immune regulation, so it is widely valued by people. Nitric oxide in the air will quickly transform into nitrogen dioxide to produce stimulation, and the nitrogen ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F3/08C09K11/06G01N21/64
CPCC07F3/08C09K11/06G01N21/643C09K2211/188C09K2211/1029
Inventor 毛佳伟朱敏吴宇徐嘉麒田华丁劲松李铭王美娜朱海
Owner 四川省产品质量监督检验检测院
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