Curcumin-based Schiff base Fe 3+ fluorescent molecular probe and preparation method thereof

A fluorescent molecular probe, curcumin technology, applied in the field of fluorescent probes, can solve the problems of cumbersome process, many steps of probe synthesis, high toxicity, etc.

Active Publication Date: 2021-12-31
XIAN THERMAL POWER RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Currently, reported Fe 3+ Fluorescent molecular probes mainly include rhodamine B type, pyridine type, naphthalimide type, and coumarin type in terms of structure. 3+ All have shown good performance in the detection, but the fly in the ointment is that most probes have many steps to synthesize, the process is cumbersome, the cost is high, and the toxicity is high

Method used

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  • Curcumin-based Schiff base Fe 3+ fluorescent molecular probe and preparation method thereof
  • Curcumin-based Schiff base Fe 3+ fluorescent molecular probe and preparation method thereof
  • Curcumin-based Schiff base Fe 3+ fluorescent molecular probe and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0032] Such as figure 2 As shown, 8.2mmol curcumin and 25.3mmol 2-aminomethylpyridine were added to 1100mmol anhydrous methanol, under nitrogen protection, stirred and mixed evenly, heated to reflux at 80°C for 4h, cooled to room temperature, and yellow needle-like crystals were precipitated. Filter, wash the precipitate 3 times with deionized water with a hydrogen conductivity of 0.056 μS / cm, recrystallize with ethanol, and dry in vacuum at 60 ° C for 2 h to prepare a curcumin-based Schiff base Fe3+ fluorescent molecular probe (CURB). The yield was 83.2%.

Embodiment 2

[0034] Such as figure 2 As shown, 9.1mmol curcumin and 27.8mmol 2-aminomethylpyridine were added to 1320mmol absolute ethanol, under nitrogen protection, stirred and mixed evenly, heated to reflux at 85°C for 5h, cooled to room temperature, and yellow needle-like crystals were precipitated. Filter, wash the precipitate 4 times with deionized water with a hydrogen conductivity of 0.06 μS / cm, recrystallize with ethanol, and dry in vacuum at 65 °C for 3 h to obtain curcumin-based Schiff base Fe 3+ Fluorescent Molecular Probe (CURB), the yield was 85.7%.

Embodiment 3

[0036] Such as figure 2 As shown, 9.8mmol curcumin and 29.5mmol 2-aminomethylpyridine were added to 1475mmol absolute ethanol, under the protection of nitrogen, stirred and mixed evenly, heated to reflux at 90°C for 6h, cooled to room temperature, and yellow needle-like crystals were precipitated. Filtrate, wash the precipitate 5 times with deionized water with a hydrogen conductivity of 0.068 μS / cm, recrystallize with ethanol, and dry under vacuum at 70 °C for 4 h to obtain curcumin-based Schiff base Fe 3+ Fluorescent Molecular Probe (CURB), the yield was 86.8%.

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Abstract

The invention belongs to the field of fluorescent probes, particularly relates to a fluorescent probe for detecting Fe 3+ and a preparation method of the fluorescent probe, and particularly relates to a curcumin-based Schiff base Fe 3+ fluorescent molecular probe which is prepared by carrying out nucleophilic addition reaction on carbonyl in curcumin molecules and a primary amine compound; The method is simple in preparation process, and reaction conditions are easy to control; the prepared fluorescent probe has excellent optical performance and chemical stability, has good recognition performance on Fe < 3 + > in a pH range of 4-9, is high in anti-interference capability and can be used for analysis and detection of trace iron in a water vapor system of a thermal power plant.

Description

technical field [0001] The invention belongs to the field of fluorescent probes, in particular to a curcumin-based Schiff base Fe 3+ Fluorescent molecular probe and its preparation method. Background technique [0002] The iron content in the water vapor system of a thermal power plant is an important basis for evaluating the corrosion and scaling of the thermal system of a power generation unit, and is one of the important monitoring indicators in the daily production of a thermal power plant. At present, the methods for determining total iron in power production feed water, furnace water and hydrophobic water are o-phenanthroline spectrophotometry (GB / T14427-2008) and graphite furnace atomic absorption method (DL / T955-2005). O-phenanthroline spectrophotometry is a traditional manual analysis method. This method is complicated to operate, has low analysis efficiency, narrow linear range, and sample water is easily polluted. Especially for low concentration (<10μg / L) iro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D213/38C09K11/06G01N21/64
CPCC07D213/38C09K11/06G01N21/643C09K2211/1029
Inventor 姬定西胡振华李俊菀李健博王园园刘焕李朋佳
Owner XIAN THERMAL POWER RES INST CO LTD
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