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Chiral cobalt hydroxide nanoparticle, and preparation method and application thereof

A technology of cobalt hydroxide and nanoparticles, applied in the field of material chemistry, can solve the problems that the direct application of biological signal molecule responsiveness has not been widely explored, and achieve the effects of prolonged relaxation time, simple operation and strong selectivity

Active Publication Date: 2022-01-11
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Exploiting the responsiveness of chiral inorganic nanomaterials to biosignaling molecules such as ROS and their immediate application as biosensors for real-time monitoring remains largely unexplored

Method used

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  • Chiral cobalt hydroxide nanoparticle, and preparation method and application thereof
  • Chiral cobalt hydroxide nanoparticle, and preparation method and application thereof
  • Chiral cobalt hydroxide nanoparticle, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Cobalt nanoparticles and its preparation method of chiral hydroxide, the following steps:

[0040] Take a clean Erlenmeyer flask with a pipette pipetted deionized water to 16mL Erlenmeyer flask, and cobalt chloride hexahydrate were weighed and taken 1mmol 2mmol of D-aspartic acid or L-aspartic acid , pH was carefully added to a Erlenmeyer flask provided with a magnetic stirrer speed was 600rpm, stirred until dissolved, then added with stirring 350μL 6M aqueous sodium hydroxide solution was mixed to 9, stirring 2min, a solution of color from pink to orange-pink and the solution of the cobalt hydroxide is the chiral nanomaterials. Pipetting a volume of liquid chiral cobalt hydroxide, plus five times the volume of isopropanol, after mixing the oscillator, 13300rpm centrifuged 10min, a pink precipitate is obtained, the pellet was resuspended in deionized water to spare to give the D- / L- chiral cobalt hydroxide nanoparticles.

[0041] Nanoparticles prepared in the present embo...

Embodiment 2

[0043] Cobalt nanoparticles and its preparation method of chiral hydroxide, the following steps:

[0044] Take a clean Erlenmeyer flask with a pipette pipetted deionized water to 16mL Erlenmeyer flask, and cobalt chloride hexahydrate were weighed and taken 1mmol 2mmol of D-glutamic acid or L-glutamic acid, carefully was added to the conical flask, magnetic stirrer speed set to 600rpm, stirred until dissolved, then added with stirring 400μL 6M aqueous sodium hydroxide solution, the pH of the mixed solution to 10, after stirring for 2min, the color of the solution pink to brown, and the solution is the chiral cobalt oxide nanoparticles. Pipetting a volume of liquid chiral cobalt oxide, plus five times the volume of isopropanol, after mixing the oscillator, 13300rpm centrifuged 10min, to give a brown precipitate, and the precipitate was resuspended in deionized water reserve, to give a D- / L- chiral cobalt oxide nanoparticles.

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Abstract

The invention relates to a chiral cobalt hydroxide nanoparticle, and a preparation method and application thereof, and belongs to the technical field of material chemistry. The chiral cobalt hydroxide nanoparticle is prepared from acidic amino acid and a cobalt salt solution under an alkaline condition; and the acidic amino acid is aspartic acid or glutamic acid. The chiral cobalt hydroxide nanoparticles have circular dichroism signals and magnetic resonance signals, and can be used for ROS detection in a complex biological environment. In ROS detection, divalent cobalt on the surfaces of the chiral cobalt hydroxide nanoparticles can be subjected to a redox reaction with reactive oxygen free radicals to obtain trivalent cobalt, so that the coordination effect of cobalt and chiral ligands on the surfaces is changed, circular dichroism and magnetic resonance signal change are generated, and ultra-sensitive detection of the chiral cobalt hydroxide nanoparticles on ROS is realized. The chiral cobalt hydroxide nanoparticle is simple and convenient to operate, high in selectivity and low in detection limit.

Description

Technical field [0001] The present invention relates to materials chemistry techniques, and in particular relates to cobalt hydroxide nanoparticles and its preparation method and application chirality. Background technique [0002] As an important signaling molecules, reactive oxygen species (ROS) can generally be produced in a variety of metabolic processes, in the regulation of many physiological functions and play a vital role in many present in the form, such as hypochlorous acid ( HClO), superoxide (O 2 - ), Hydroxyl radical (-OH), hydrogen peroxide (H 2 O 2 ) And singlet oxygen (1O 2 . However, due to the ROS with strong oxidation ability, it may oxidize proteins, lipids and nucleic acids functional cells, resulting in serious injury. Excessive accumulation of ROS can cause oxidative stress in vivo, but also associated with many pathological conditions, including cancer, neurological disorders and cardiovascular disease. [0003] Nanomaterials and enormous surface area int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G51/04G01N21/19G01N21/64G01N24/08
CPCC01G51/04G01N21/19G01N21/6486G01N24/088C01P2004/64C01P2002/84C01P2002/85C01P2002/72
Inventor 徐丽广李称胥传来匡华马伟孙茂忠刘丽强吴晓玲宋珊珊胡拥明郝昌龙
Owner JIANGNAN UNIV
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