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Application of metformin in relief of ulcerative colitis induced by high glucose and high fat

A technology for ulcerative colitis and metformin, applied in the field of biomedicine, can solve the problems of easy recurrence of the disease, increase the economic and mental burden of patients, poor treatment effect, etc., and achieve the effect of low price

Pending Publication Date: 2022-01-18
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

However, there are still poor treatment effects, and the disease is prone to recurrence, which seriously increases the economic and mental burden of patients.

Method used

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  • Application of metformin in relief of ulcerative colitis induced by high glucose and high fat
  • Application of metformin in relief of ulcerative colitis induced by high glucose and high fat
  • Application of metformin in relief of ulcerative colitis induced by high glucose and high fat

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Experimental program
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Effect test

Embodiment 1

[0017] 1. Grouping of mice and establishment of ulcerative colitis model

[0018] Mice were divided into normal control group (control), colitis group (DSS), high glucose and high fat induced colitis group (HGFD+DSS). The mouse strain was 4-week-old wild-type C57BL / 6 male mice. A mouse model of ulcerative colitis was established using 2% dextran sulfate sodium salt (DSS).

[0019] 1) Normal control group: normal diet and drinking water.

[0020] 2) Colitis group: Add 2% DSS to the drinking water of the mice at the age of 8 weeks, and continue to feed them for 7 days.

[0021] 3) High-sugar and high-fat-induced colitis group: 4-week-old mice were fasted overnight for about 16 hours, and injected intraperitoneally with 2.5 mg / mL streptozotocin (STZ) solution, and the injection volume was 20 mL / kg (equivalent to 50 mg / kg body weight), once a day for 5 consecutive days. Fasting is required on the first day, and no fasting is required for the next 4 days. Five days after the i...

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Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to application of metformin in relief of ulcerative colitis induced by high glucose and high fat. According to the invention, the metformin is adopted to relieve mouse colitis induced by high glucose and high fat. In-vivo experiments prove that the development of the ulcerative colitis can be aggravated by high-sugar and high-fat diet, resulting in that the weight of a mouse is reduced more quickly, and the death rate is higher. Use of the metformin can enable the clinical symptoms of the mouse to be improved, the colon length and the weight can be recovered to a certain extent, and the histological inflammation score can be reduced. Experimental results show that the use of the metformin is beneficial for relieving the ulcerative colitis induced by high glucose and high fat.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an application of metformin in relieving ulcerative colitis induced by high sugar and high fat. Background technique [0002] Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that primarily affects the colon and rectum. Multiple factors are involved in the pathogenesis of UC. In recent years, the incidence of UC has been on the rise, with an incidence rate of 11.6 / 100,000. UC has a high incidence in developed countries and a sharp increase in developing countries, and has become a global burden. And the prevalence of diabetes is increasing year by year, and it is estimated that the incidence will be as high as 9.9% in 2035. The incidences of ulcerative colitis (UC) and diabetes mellitus (DM) are on the rise, and studies have reported that DM is closely related to a higher incidence of IBD and more severe IBD disease. [0003] Ulcerative colitis is very difficul...

Claims

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Application Information

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IPC IPC(8): A61K31/155A61P1/00A61P1/04
CPCA61K31/155A61P1/00A61P1/04
Inventor 黄冰蒋文刘思德李爱民林莹李艺闻林志昭庄康敏
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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