Highly dispersible zinc phthalocyanine-silica nanotubes and preparation method therefor
A silicon dioxide, highly dispersible technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as damage to electronic systems, increased production costs, and decreased photoactivity of photosensitizers, achieving low cost and high dispersibility , excellent stability
Pending Publication Date: 2022-01-18
李相虎
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Problems solved by technology
[0007] However, the above-mentioned method must go through multi-stage complicated chemical functionalization steps, which may lead to the destruction of the original strongly bonded electronic system of the photosensitizer, resulting in the loss of the photosensitizer during the functionalization step. The problem of decreased photoactivity
In addition, performing complex chemical functionalization steps also leads to issues of reduced efficacy and increased production costs
Method used
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Embodiment 1
[0065] 1 mmol of glycyl dodecylamide (GDA) was used as a gel-generator, and after adding 20 ml of water and 2 ml of ethanol and heating until the solution became transparent, it was stirred at 2°C Leave it on for about 1 hour. After adding thereto 5 ml of an aqueous solution mixed with 0.01 mmol of ZnPc (Zinc Phtalocyanine) (nanostructure or general reagent provided by POSTECH), stirring was added for about 10 minutes with a magnetic bar to form a complex. Next, 4 mmol of tetraethyl orthosilicate (TEOS), which is a silica precursor, was additionally added thereto and vigorously stirred for about 1 hour, and then stored in a static state (static condition) at room temperature for 3 days. . The produced sample was filtered for drugs and the filtrate was removed, followed by washing impurities with distilled water, and then drying at room temperature for 2 days by vacuum drying to produce zinc phthalocyanine-silica nanotubes.
[0066] exist figure 1 The transmission electron m...
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The present invention relates to highly dispersible zinc phthalocyanine (ZnPc)-silica nanotubes, and a preparation method therefor, and, more specifically, to: highly dispersible ZnPc-silica nanotubes, which improve the dispersibility of ZnPc, thereby enabling a stable increase in the uptake thereof into the human body; and a preparation method therefor. The present invention relates to highly dispersible ZnPc-silica nanotubes, and the preparation method therefor, the method comprising: a first step of mixing templates and an alcohol solution so as to prepare a nanotube solution containing nanotube templates; a second step of adding a ZnPc solution to the nanotube solution and stirring same so as to disperse same, thereby preparing a ZnPc-nanotube solution in which ZnPc complexes are coupled into the nanotube templates; a third step of adding a silica precursor to the ZnPc-nanotube solution and stirring same so as to perform silication, thereby preparing a ZnPc-silica nanotube solution; and a fourth step of filtering and drying the ZnPc-silica nanotube solution so as to prepare a ZnPc-silica nanotube powder.
Description
technical field [0001] The invention relates to a highly dispersible zinc phthalocyanine-silicon dioxide nanotube and a manufacturing method thereof, in particular to a highly dispersible zinc phthalocyanine- Silica nanotubes and methods of making the same. Background technique [0002] Photosensitizers used in photodynamic therapy (PDT) include porphyrin derivatives, chlorins, porphycenes, and phthalicyanines (Pes). [0003] Among them, metallo phthalocyanine (MPc), as a ring substitute of phthalocyanine (Pc), can easily adjust the photodynamic properties according to the type of functional groups that can be introduced and the type of central metal ion. [0004] In particular, zinc phthalocyanine (ZnPc) has a closed d-shell structure and Zn(II) ion as a diamagnetic central metal ion, so it has a long-lived triplet electronic state (triplet electrical state) yield is excellent, which can show excellent photodynamic properties. Furthermore, zinc phthalocyanine has a wide ...
Claims
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IPC IPC(8): A61K41/00A61K47/52A61K47/69
CPCA61K41/0071A61K47/52A61K47/6923A61K47/6949B82Y5/00B82Y30/00B82Y40/00A61K47/69
Inventor 李相虎
Owner 李相虎