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Preparation method and application of Schiff base ligand and multi-core rare earth complex thereof

A Schiff base and nuclear rare earth technology, applied in the field of nucleotide detection, can solve problems such as poor stability, complicated use, and influence on test results, and achieve good stability, simple and fast use, and simple and fast methods

Active Publication Date: 2022-01-28
WENZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use methods of the existing fluorescent probes are relatively complicated, and the stability is poor, and it is easy to affect the detection results.
Therefore, the existing technology has the problems of complicated use and poor stability.

Method used

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  • Preparation method and application of Schiff base ligand and multi-core rare earth complex thereof
  • Preparation method and application of Schiff base ligand and multi-core rare earth complex thereof
  • Preparation method and application of Schiff base ligand and multi-core rare earth complex thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1. A kind of Schiff base ligand, structural formula (I) is as follows:

[0023]

[0024] A kind of preparation method of Schiff base ligand comprises synthesis and separation, 2-hydroxyl-3-ethoxybenzaldehyde and tetramethylenediamine are reacted with molar ratio 2:1, then make with 50mL absolute ethanol The reaction solvent was heated and stirred under reflux for 4 hours to complete the reaction. After the reaction was completed, it was filtered while it was hot. After the filtrate was cooled, a yellow precipitate was precipitated. The obtained yellow precipitate was washed with ether three times and then vacuum-dried to obtain the Schiff base ligand.

[0025] A polynuclear rare earth complex, the multinuclear rare earth complex is a rectangular hexanuclear complex, in which four Tb 3 + and two Zn 2 + by Schiff base ligand H 2 Surrounded by L; the Schiff base ligand H 2 L is the aforementioned Schiff base ligand.

[0026] The structural formula of the po...

Embodiment 2

[0031] Example 2. A kind of Schiff base ligand, structural formula (I) is as follows:

[0032]

[0033] Chemical reaction formula 1:

[0034]

[0035] The preparation method of Schiff base ligand is:

[0036] Weigh 2.2g of tetramethylenediamine into a 250ml round bottom flask, add 50mL of absolute ethanol and stir to dissolve; add 8.3g of 2-hydroxy-3-ethoxybenzaldehyde to the above solution, heat and stir to reflux 4h; After the reaction was completed, it was allowed to stand for cooling, and a yellow precipitate precipitated out. After filtration, the yellow precipitate was washed with ether three times, and dried in vacuo to obtain the target product (Schiff base ligand), with a yield of 73%.

[0037] The nuclear magnetic analysis of Schiff base ligand formula (I): 1 H NMR (400MHz, CDCl 3 )δ14.04(s,2H),8.32(s,2H),6.90-6.92(dd,2H),6.85-6.87(dd,2H),6.75-6.79(t,2H),4.09-4.14(q, 4H), 3.63(q, 4H), 1.81(m, 4H), 1.46-1.50(t, 6H). 13 C NMR (101MHz, CDCl 3 ) δ 164.91, 15...

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Abstract

The invention discloses a preparation method and application of a Schiff base ligand and a multi-core rare earth complex thereof, the structural formula (I) of the Schiff base ligand is disclosed in the invention; the multi-core rare earth complex is a rectangular six-core complex, and four Tb < 3 + > and two Zn < 2 + > are surrounded by Schiff base ligand H2L; the Schiff base ligand H2L adopts the Schiff base ligand disclosed by the invention. The method has the characteristics of simplicity and rapidness in use and good stability.

Description

technical field [0001] The invention relates to the field of nucleotide detection, in particular to a preparation method and application of a Schiff base ligand and a polynuclear rare earth complex thereof. Background technique [0002] Currently, the development of analytical techniques for the detection of biological species has important clinical and pharmaceutical implications. Guanosine-5-monophosphate (GMP) is an important nucleotide that plays an intermediate role in the synthesis of nucleic acids and plays a vital role in metabolic processes. Currently, many traditional analytical techniques, such as electrochemical methods, liquid chromatography-mass spectrometry, and anion-exchange liquid chromatography, have been used to detect GMPs. In recent years, fluorescent probes have attracted extensive attention due to their advantages such as high sensitivity, fast response, and convenient operation. For example, some fluorescent sensors, such as organic chemical sensor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C251/24C07C249/02C07F19/00C09K11/06G01N21/64
CPCC07C251/24C07F5/003C09K11/06G01N21/6428C07B2200/13C09K2211/182C09K2211/188G01N2021/6443
Inventor 朱挺刘洁妮李宾马亚男杨小平
Owner WENZHOU UNIVERSITY