Closed-loop control digital microfluidic system and control method thereof

A closed-loop control, digital micro-flow technology, applied in the field of biochemical detection, can solve problems such as poor droplet movement stability, and achieve high sensitivity, rapid detection, and improved accuracy.

Active Publication Date: 2022-02-01
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to solve the problem of poor stability in real-time monitoring and adjustment of droplet movement when the existing digital microfluidic chip is driven by liquid, and proposes a closed-loop control digital microfluidic system and its control method

Method used

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  • Closed-loop control digital microfluidic system and control method thereof
  • Closed-loop control digital microfluidic system and control method thereof
  • Closed-loop control digital microfluidic system and control method thereof

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specific Embodiment approach 1

[0035] DETAILED DESCRIPTION One: Bindings figure 1 and figure 2 In this embodiment, the embodiment of the present embodiment controls the digital microfluidic system,

[0036] The system includes: AC or DC power supply 1, two digital microfluidic chips 3, detecting controller 4, drive controller 5, microprocessor 6, and display 7;

[0037] The two digital microfluidic chips 3 are opposed, and the electrode sheets of the two digital microfluidic chip 3 correspond to one or one;

[0038] Each of the electrode sheets of each digital microfluidic chip 3 is connected to the wire and the first relay 2, and the switch control signal output of each first relay 2 is connected to the drive controller 5. end;

[0039] The drive controller 5 is configured to control whether the electrodes opposed to the digital microfluidic chip 3 are controlled by controlling the electrodes of the digital microfluidic chip 3 on whether the electrode opposite to the digital microfluidic chip 3 is controlled b...

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Abstract

The invention discloses a closed-loop control digital microfluidic system and a control method thereof, and belongs to the field of biochemical detection. According to the invention, the problem of poor stability of real-time monitoring and adjustment of droplet movement during liquid driving of the existing digital micro-fluidic chip is solved. Each electrode plate of each digital microfluidic chip is connected with an alternating-current or direct-current power supply through a wire and a first relay, and a switch control signal end of each first relay is connected with a switch control signal output end of a driving controller; and the driving controller is used for controlling whether an electrode pair opposite to the digital micro-fluidic chip is powered on or not by controlling the opening or closing of the first relay, and the electrode pair is powered on to drive liquid drops. The system and the method are suitable for control of the microfluidic chip.

Description

Technical field [0001] The present invention belongs to the field of biochemical detection, and more particularly to a digital microfluidic system and a control method thereof. Background technique [0002] Digital microfluidic chip, using dielectric wetting techniques to manipulate the microphone droplets, and realize the detection function of traditional laboratory large equipment. Because of its high-throughput, low liquid volume, and rapid detection ability, there is a broad development prospect in the field of medical testing. Digital microfluidization uses dielectric wetting principle, by applying a potential on the electrode, changing the infiltration between the dielectric layer above the electrode and the droplets, thereby changing the shape and position of the droplet. However, the current microfluidic chip uses an open loop control method, and a voltage is applied on different electrodes in accordance with fixed frequencies. Ideally, the droplets will move in the elect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/50273B01L2200/06B01L2200/143B01L2400/0427
Inventor 陈亮梁昊付强姜舒月刘晓为张海峰曹伽牧
Owner HARBIN INST OF TECH
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