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Polyhydroxy cyclohexene compound as well as preparation method and application thereof

A technology of polyhydroxycyclohexene and compounds, which is applied in the field of phytochemistry and can solve problems such as α-glucosidase that has not been reported

Pending Publication Date: 2022-02-08
HAINAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the dual functions of hydrolysis and transglycosidation in the catalytic reaction of sugar. At present, there is no report on the polyhydroxycyclohexene compounds isolated from quincea quinquefolius, and there is no such compound that inhibits α-glucosidase. reports in the app

Method used

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  • Polyhydroxy cyclohexene compound as well as preparation method and application thereof
  • Polyhydroxy cyclohexene compound as well as preparation method and application thereof
  • Polyhydroxy cyclohexene compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of Polyhydroxycyclohexene Compounds

[0028] 10Kg of the dried stems of Paradigmia mellifera is conventionally leached with 75% v / v ethanol for 3 times for 7 days each time to obtain the extract, which is concentrated under reduced pressure into a paste, and the temperature for concentration under reduced pressure is 30°C. The pressure is -0.06MPa, and 1000g of the extract of Paradise melaka is obtained.

[0029] Dilute the extract with distilled water (3L) to form a suspension, sequentially extract with petroleum ether (3L x 3 times) and ethyl acetate (3L x 3 times), and concentrate the aqueous phase into an extract (about 412g). The temperature is 30℃, the pressure is -0.06MPa, silica gel column chromatography is carried out, and the mixed solvent of petroleum ether-ethyl acetate (100:0-0:100, V / V) and ethyl acetate-methanol (100:0-0 : 100, V / V) Carry out silica gel column chromatography in increasing polarity, and collect fractions about 400mL each time....

Embodiment 2

[0031] Preparation of Polyhydroxycyclohexene Compounds

[0032] 10Kg of the dried stems of Paradigmia mellifera is routinely leached with 75% v / v ethanol for 3 times for 7 days each time to obtain the extract, which is concentrated under reduced pressure into a paste, and the temperature for concentration under reduced pressure is 70°C. The pressure is -0.15MPa, and 1000g of the extract of Melonia sinensis is obtained.

[0033] Dilute the extract with distilled water (3L) to form a suspension, sequentially extract with petroleum ether (3L x 3 times) and ethyl acetate (3L x 3 times), and concentrate the aqueous phase into an extract (about 412g). At 70°C, the pressure is -0.15MPa, perform silica gel column chromatography, use petroleum ether-ethyl acetate mixed solvent (100:0-0:100, V / V) and ethyl acetate-methanol (100:0-0 : 100, V / V) Carry out silica gel column chromatography in increasing polarity, and collect fractions about 400mL each time. Through TLC detection, the comb...

Embodiment 3

[0035] Preparation of Polyhydroxycyclohexene Compounds

[0036] 10Kg of the dried stems of Paradigmia mellifera is routinely extracted with 75% v / v ethanol 3 times for 7 days each time to obtain the extract, which is concentrated under reduced pressure into a paste, and the temperature of the concentration under reduced pressure is 45°C. The pressure is -0.095 MPa, and 1000g of the extract of Melonia sinensis is obtained.

[0037] Dilute the extract with distilled water (3L) to form a suspension, sequentially extract with petroleum ether (3L x 3 times) and ethyl acetate (3L x 3 times), and concentrate the aqueous phase into an extract (about 412g). at 45°C and the pressure at -0.095 MPa, conduct silica gel column chromatography, use petroleum ether-ethyl acetate mixed solvent (100:0-0:100, V / V) and ethyl acetate-methanol (100:0-0 : 100, V / V) Carry out silica gel column chromatography in increasing polarity, and collect fractions about 400 mL each time. Through TLC detection,...

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Abstract

The invention discloses a polyhydroxy cyclohexene compound as well as a preparation method and application thereof, and belongs to the technical field of phytochemistry. The structural formula of the polyhydroxy cyclohexene compound is as shown in formula (1), and the invention also discloses a preparation method of the compound and application of the compound in preparation of hypoglycemic drugs. The polyhydroxy cyclohexene compound disclosed by the invention can be used for inhibiting the activity of alpha-glucosidase and can be used for preparing a medicine for reducing blood sugar.

Description

technical field [0001] The invention relates to the technical field of phytochemistry, in particular to a polyhydroxycyclohexene compound and its preparation method and application. Background technique [0002] Paradise Melonia is a plant of the genus Melonaceae in the Annonaceae family. The plant can be used as medicine, the stems and leaves can cure fractures and edema, and the whole plant can treat rheumatic bone pain, numbness of hands and feet, etc. α-glucosidase, also known as glucosyltransferase, is a kind of hydrolase. It has the dual functions of hydrolysis and transglycosidation in the catalytic reaction of sugar. At present, there is no report on the polyhydroxycyclohexene compounds isolated from quincea quinquefolius, and there is no such compound that inhibits α-glucosidase. reports in the application. Contents of the invention [0003] In view of this, the present invention proposes a polyhydroxycyclohexene compound extracted and separated from Paradigmia...

Claims

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Application Information

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IPC IPC(8): C07C35/18C07C29/76A61P3/10
CPCC07C35/18A61P3/10C07C2601/16C07B2200/07Y02A50/30
Inventor 周学明陈光英宋鑫明李小宝
Owner HAINAN NORMAL UNIVERSITY
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