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Plug-shaped implant for the replacement and regeneration of biological tissue and method for preparing the implant

A technology of biological tissue and implants, applied in the field of implants, can solve problems such as degeneration, cartilage tissue unable to withstand joint biomechanical challenges, and delay

Pending Publication Date: 2022-02-08
JOINTSPHERE BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cartilage tissue regenerated with these techniques was unable to withstand the biomechanical challenges in the joint and already began to degenerate within 18 months
Therefore, it is impossible to significantly delay joint replacement by artificial joints, let alone prevent joint replacement by artificial joints

Method used

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  • Plug-shaped implant for the replacement and regeneration of biological tissue and method for preparing the implant
  • Plug-shaped implant for the replacement and regeneration of biological tissue and method for preparing the implant
  • Plug-shaped implant for the replacement and regeneration of biological tissue and method for preparing the implant

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0086] Example 1: Polycarbonate-aliphatic: Poly(hexamethylene carbonate urethane)-diurea biomaterial MVH313, see Table 1 below.

[0087] This one-pot two-step biomaterial MVH313 was prepared by using 2.0 molar equivalents of 1,6-diisocyanatohexane to 1.0 molar equivalents of poly(hexamethylene carbonate) diol (MW=2000) Functionalization (step 1) and subsequent chain extension (step 2) were performed using 1.0 molar equivalent of 1,6-diaminohexane.

[0088] Specifically, the aliphatic poly-urethane-urea-hexamethylene carbonate biomaterials of the middle section 3 and the top section 4 were produced as follows (ref. image 3 ). Poly(hexamethylene carbonate) diol (MW=2000; 23.9 g, 11.9 mmol) was weighed in a 500 mL 3-neck flask and dried under vacuum by heating to 75° C. overnight and then allowed to cool to room temperature. Under argon atmosphere, 1,6-diisocyanatohexane (4.1 g, 23.9 mmol), DMAc (20 mL) and a drop of Sn(II) bis(2-ethylhexanoate) were added after which the mi...

example 2

[0092] Example 2 : polyether-aromatic: poly(tetrahydrofurancarbamate)-diurea biomaterial MVH309B, see Table 1 below.

[0093] Biomaterial MVH309B was also produced in a one-pot two-step experimental procedure similar to that described in detail for biomaterial MVH313. Specifically, biomaterial MVH309B was prepared by functionalizing 1.0 molar equivalents of poly-tetrahydrofuran diol (MW=2000) with 1.33 molar equivalents of bis(4-isocyanatophenyl)methane (MDI) (step 1), and then chain extension (step 2) using 0.33 molar equivalents of 1,6-diaminohexane. Biomaterial MVH309B was isolated as a white, flexible, tough elastomeric polymer.

example 3

[0094] Example 3: Polyether-aliphatic: Poly(tetrahydrofurancarbamate)-diurea biomaterial MVH312, see Table 1 below.

[0095] Biomaterial MVH312 was also produced in a one-pot two-step experimental procedure similar to that described in detail for biomaterial MVH313. Specifically, biomaterial MVH312 was prepared by functionalizing 1.0 molar equivalents of poly-tetrahydrofuran diol (MW=2000) with 2.0 molar equivalents of 1,6-diisocyanatohexane (step 1) , and followed by chain extension using 1.0 molar equivalent of 1,6-diaminohexane (step 2). The biomaterial MVH312 was isolated as a flexible, tough elastomeric polymer.

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Abstract

The invention describes a non-biodegradable implant for the replacement and regeneration of biological tissue in the shape of a plug, comprising a base section (2) configured for anchoring in bone tissue, a middle section (3) configured for replacing cartilage tissue of an intermediate and deep zone of the cartilage layer and having a thickness of at least 0.2 mm, and a top section (4) configured for growing cartilage tissue onto and into, thus regenerating a superficial zone of the cartilage layer, wherein the middle and top section comprise the same thermoplastic elastomeric material, which is porous in the top section, and non- porous in the middle section, wherein the thermoplastic elastomeric material comprises a linear block copolymer comprising urethane and urea groups, and is substantially free of an added peptide compound having cartilage regenerative properties, and wherein the base section material comprises one of a biocompatible metal, such as titanium or titanium alloy, ceramic, such as sintered crystalline hydroxylapatite, mineral, such as phosphate mineral, and polymer, optionally a hydrogel polymer, and combinations thereof.

Description

technical field [0001] The invention relates to an implant in the shape of a plug for the replacement and regeneration of biological tissue. In particular, the present invention relates to an implant in the shape of a plug for the replacement and regeneration of osteochondral structures. The invention further relates to a method for producing said implant and an osteochondral structure comprising said implant. Background technique [0002] Osteochondral structures refer to structures that include cartilage and bone. Typical osteochondral structures can be found in the thighbone (femur), shinbone (tibia) and kneecap (patella). Because the bone surface is covered with a relatively thick layer of articular (hyaline) cartilage, such structures fit together tightly and move smoothly. A (bone)chondral defect is any type of damage to the articular cartilage and optionally the underlying (subchondral) bone. Typically, (osteo)chondral defects occur at specific bearing points, eg ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/30A61L27/56
CPCA61F2/30756A61F2/3094A61F2/30965A61F2002/30011A61F2002/3092A61F2002/30225A61F2002/30971A61F2002/30766A61L27/56A61L27/18C08L75/04C08L69/00A61L27/48A61L27/54A61F2002/30759A61L2430/06A61L2300/44A61F2002/30065A61F2002/30069B29C43/003B29C43/02B29C43/52B29K2021/003B29L2031/7532
Inventor E·G·M·赫姆森E·J·H·范布尔G·W·梅尔瑟姆P·M·E·A·弗朗桑
Owner JOINTSPHERE BV