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Use of mixture of lauroyl macrogolglyceride and polyethylene glycol as excipient

A technology of lauroyl polyoxyethylene glyceride and polyethylene glycol, which is used in pharmaceutical or cosmetic applications to produce pharmaceutical or cosmetic compositions containing such excipients, which can solve problems such as loss

Pending Publication Date: 2022-02-18
GATTEFOSSE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process requires the use of an oven and therefore involves manipulation of hot liquid products, which is the first disadvantage
In addition, the manipulation of the material can lead to losses, depending on the final usage: this is the second disadvantage

Method used

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  • Use of mixture of lauroyl macrogolglyceride and polyethylene glycol as excipient
  • Use of mixture of lauroyl macrogolglyceride and polyethylene glycol as excipient
  • Use of mixture of lauroyl macrogolglyceride and polyethylene glycol as excipient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Embodiment 1: the preparation of excipient of the present invention

[0062] The different formulations of solid pellets obtained using the method described above are listed in Table I below.

[0063] [Table I]

[0064]

[0065] Use the following weight ratio: 65 / 35 44 / 14 / PEG 6000 mixture obtained solid pellets as figure 2 shown. They are opaque and flat in the shape of a disc.

[0066] 65 / 35 by weight The dropping point of the 44 / 14 / PEG 6000 mixture was determined to be 58.3°C. 60 / 40 by weight The dropping point of the 44 / 14 / PEG 6000 mixture was determined to be 58.6°C.

Embodiment 2

[0067] Embodiment 2: Effect of PEG on the dissolution of active ingredients

Embodiment 21

[0068] Example 2.1: Piroxicam

[0069] use 44 / 14 formulated the active ingredient piroxicam. The obtained mixture is made into capsules.

[0070] The solubility of piroxicam in water at 25°C is 23mg / L.

[0071] Get capsules with the following formula: 20mg piroxicam and 660mg 44 / 14.

[0072] The dissolution properties of piroxicam were compared with different solid pellet formulations obtained in the same manner as above, except that 44 / 14 had previously been prepared in the presence of PEG, as described above.

[0073] got Figure 3a and 3b Graph showing the release L (%) of the active ingredient as a function of the time t in minutes, where:

[0074] Figure 3a

[0075] - Curve B1 (invention) corresponds to piroxicam / A mixture of 44 / 14 / PEG 4000, wherein The weight ratio of 44 / 14 / PEG 4000 is 55 / 45;

[0076] - Curve B2 (invention) corresponds to piroxicam / A mixture of 44 / 14 / PEG 6000, wherein The weight ratio of 44 / 14 / PEG 6000 is 65 / 35;

[0077] - Cur...

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Abstract

The invention concerns the use, as a pharmaceutical or cosmetic excipient, of a composition which is solid at ambient temperature and in the form of individualized particles, the composition comprising: lauroyl macrogolglyceride, and polyethylene glycol.

Description

technical field [0001] The present invention relates to the field of pharmacy or cosmetics. In particular, the present invention relates to excipients based on lauroyl macrogolglyceride and polyethylene glycol (PEG) for pharmaceutical or cosmetic applications. The invention also relates to methods for the production of pharmaceutical or cosmetic compositions comprising such excipients. Background technique [0002] 44 / 14, named "Lauroylpolyoxyethylene Glycerides" in the European Pharmacopoeia, is a known excipient that has been marketed by the applicant for many years. The product consists of a mixture of mono-, di- and tri-glycerides and mono- and di-esters of PEG with saturated fatty acids containing 8 to 18 carbon atoms. The mixture also contains small proportions of PEG and free glycerol. Such mixtures can be prepared by alcoholysis of hydrogenated vegetable oils, such as hydrogenated coconut oil, with polyethylene glycol. This oil is in turn composed of triglyceri...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/10A61K47/14A61K8/02A61K8/85A61K8/86A61Q19/00
CPCA61K9/1647A61K9/1641A61K8/86A61K47/10A61K47/14A61K8/85A61Q19/00A61K8/0216A61K47/34A61K2800/10A61K8/0241A61K2800/5922A61K2800/594A61K2800/41A61K9/1682A61K47/36
Inventor A·福雷斯特J-D·罗迪耶
Owner GATTEFOSSE SA