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Semen armeniacae amarae extract with skin oxidation resisting effect and application thereof

A bitter almond extract technology, applied in the field of bitter almond extract, to achieve the effect of inhibiting oxidation and delaying aging

Pending Publication Date: 2022-02-25
上海小方制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, antioxidants such as N-acetylcysteine ​​​​have various side effects as chemicals, so they cannot be used as daily skin care products for a long time

Method used

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  • Semen armeniacae amarae extract with skin oxidation resisting effect and application thereof
  • Semen armeniacae amarae extract with skin oxidation resisting effect and application thereof
  • Semen armeniacae amarae extract with skin oxidation resisting effect and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the preparation of bitter almond extract

[0036] Take 5 kg of bitter almond decoction pieces and mash; add water to extract twice, and feed after boiling; add 8 times the amount of water for the first time, decoct for 50 minutes, add 6 times of water for the second time, and decoct for 30 minutes; filter, and measure the density at 60 ° C , concentrated to the corresponding consistency (1.08 ~ 1.10); slowly add absolute ethanol, stir while adding, so that the alcohol content reaches 70%, let it stand overnight, filter, after the filtrate recovers ethanol, concentrate in vacuum below 60°C to thick paste.

Embodiment 2

[0037] Embodiment 2: the preparation of bitter almond extract

[0038] Take 1 kg of bitter almond decoction slices and mash; add water to extract twice, and feed after boiling; add 8 times the amount of water for the first time, decoct for 50 minutes, add 6 times of water for the second time, and decoct for 30 minutes; filter, and measure the density at 60 ° C , concentrated to the corresponding consistency (1.08 ~ 1.10); slowly add absolute ethanol, stir while adding, so that the alcohol content reaches 70%, let it stand overnight, filter, after the filtrate recovers ethanol, concentrate in vacuum below 60°C to thick paste.

Embodiment 3

[0039] Embodiment 3: the preparation of bitter almond extract

[0040]Take 2 kg of bitter almond decoction pieces and mash; add water to extract twice, and feed after boiling; add 8 times the amount of water for the first time, decoct for 50 minutes, add 6 times of water for the second time, and decoct for 30 minutes; filter, and measure the density at 60 ° C , concentrated to the corresponding consistency (1.08 ~ 1.10); slowly add absolute ethanol, stir while adding, so that the alcohol content reaches 70%, let it stand overnight, filter, after the filtrate recovers ethanol, concentrate in vacuum below 60°C to thick paste.

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Abstract

The invention discloses a semen armeniacae amarae extract with a skin oxidation resisting effect. The extraction method of the semen armeniacae amarae extract comprises the following steps: weighing semen armeniacae amarae decoction pieces, and mashing the semen armeniacaedecoction pieces; adding water to extract twice, combining the two decoctions, standing, and filtering to obtain a liquid medicine; concentrating at a temperature of 10 to 100 DEG C until the thickness of the liquid medicine is 1.00 to 2.00; slowly adding absolute ethyl alcohol, and stirring while adding until the alcohol content reaches 20-90%; and standing for 6-36 hours, filtering, recovering ethanol from the filtrate, and carrying out vacuum concentration at 20-90 DEG C to obtain the semen armeniacae amarae extract with the skin oxidation resisting effect. According to the invention, starting from exogenous factors of skin aging, the skin aging can be delayed by inhibiting the oxidation of the skin. The invention further discloses application of the semen armeniacae amarae extract with the skin oxidation resisting effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to a bitter almond extract with anti-oxidation effect on the skin. The present invention also relates to the application of the bitter almond extract which has anti-oxidation effect on the skin. Background technique [0002] Skin aging can be divided into endogenous factors and exogenous factors, and can be divided into two parts: physiological factors and pathological factors. Among them, human skin aging occupies the first place among physiological factors, and existing studies have shown that the aging of the human skin dermis is the main cause of skin aging. Among the endogenous factors, the methylation of DNA in the human body occupies an important position, which can simultaneously regulate cell proliferation and apoptosis, and the transcription factor P53 is activated when DNA is damaged, which further mediates the development regulation of the skin and makes the ski...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K8/9789A61Q19/08A61P17/18A23L33/105
CPCA61K36/736A61K8/9789A61Q19/08A61P17/18A23L33/105A23V2002/00A23V2200/318A23V2250/21
Inventor 方家辰张宁邹纯朴王冰
Owner 上海小方制药股份有限公司
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