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TMF1 polymorphic site as gene marker and psoriasis kit combined with methotrexate

A technology of methotrexate and kits, applied in the biological field, can solve problems such as related mechanisms that have not been reported, and achieve the effect of high treatment efficiency

Pending Publication Date: 2022-03-01
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

However, there is no report on the mechanism of TMF1 and the mechanism related to the pathogenesis of psoriasis.

Method used

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  • TMF1 polymorphic site as gene marker and psoriasis kit combined with methotrexate

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0084] Example Correlation study between TMF1 gene polymorphism and clinical curative effect of MTX in treating psoriasis

[0085] Materials and Methods:

[0086] 1) Patients with psoriasis: Patients with psoriasis who visited the Psoriasis Specialized Clinic of the Department of Dermatology of Huashan Hospital from January 2015 to June 2019 were selected as observation objects.

[0087] 2) Medication intervention method: MTX7.5mg was orally administered once a week in the first and second weeks of treatment, 10mg was orally administered once a week from weeks 3 to 4, and 12.5mg was orally administered once a week from weeks 5 to 12.

[0088] 3) Inclusion criteria

[0089] (1) Age 18-60;

[0090] (2) Patients diagnosed with vulgaris, arthropathic, erythrodermic and pustular psoriasis, body surface area involved (BSA)>10% or psoriasis area and severity index (PASI)> 10;

[0091] (3) Fill out the complete epidemiological survey form and sign the informed consent form.

[00...

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Abstract

The invention belongs to the technical field of biology, and relates to a gene marker and a detection kit for the curative effect of a psoriasis drug. The invention provides an application of a site rs2292199 in preparation of a medicine for treating psoriasis, wherein the genotype of the rs2292199 is AG or AA. The invention also relates to a detection kit for predicting the clinical curative effect of methotrexate (MTX) on psoriasis, and the kit predicts the clinical curative effect of MTX by detecting the SNP site of the TMF1 of a psoriasis patient. Clinical doctors can be assisted in classifying psoriasis patients and selecting MTX treatment intervention schemes, and a basis is provided for improving the clinical curative effect of MTX.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a detection kit for the curative effect of psoriasis drugs, in particular to a novel detection kit for predicting the clinical curative effect of methotrexate (MTX) in treating psoriasis. The SNP loci of TMF1 in patients with psoriasis predict the clinical efficacy of MTX. It can guide clinicians to formulate appropriate MTX treatment intervention programs and provide a basis for improving the clinical efficacy of MTX. Background technique [0002] The prior art discloses that psoriasis is a common chronic inflammatory disease that can affect multiple organs such as skin, nails, joints, kidneys, and cardiovascular. Due to the high incidence of the disease, long course of disease, easy recurrence, and difficult to cure, it brings serious physical and mental damage and economic burden to patients. Among the drug interventions commonly used in clinical practice, the effective rate of co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11A61K31/519A61P17/06
CPCC12Q1/6883A61K31/519A61P17/06C12Q2600/156C12Q2600/106
Inventor 颜克香徐金华张学军
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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