Personalized drug controlled release system topological optimization method and system

Abstract

According to the topological optimization method and system for the personalized drug controlled release system, the design freedom degree is higher, the structural design with the controllable internal concentration of the drug controlled release system can be achieved in combination with the target, the personalized drug release requirement is met, and the drug treatment effect is improved to the maximum extent. Comprising the steps that S1, a topological optimization model is created, and the creation process comprises the steps that a design domain is established in combination with the medication environment of a drug controlled release system, target material attributes are differentially controlled through an SIMP interpolation model based on the idea of a variable density method, and boundary conditions, target functions, constraint conditions and design variables are set in combination with target medication requirements; s2, performing finite element analysis on the topological optimization model, and calculating to obtain sensitivity information of a target function to a design variable; s3, based on the sensitivity information, carrying out repeated iterative optimization on the topological optimization model until an optimization convergence condition is met; and S4, performing projection function calculation on the design variables meeting the optimization convergence condition to obtain an optimal topological structure.

Description

technical field [0001] The invention relates to the technical field of optimal control of drug release behavior, in particular to a topology optimization method and system for a personalized drug controlled release system. Background technique [0002] With the development of modern medical technology, "precision medicine" as a new medical model has attracted the attention of researchers in the field of medicine. Compared with traditional medicine, precision medicine can provide patients with more accurate diagnosis and treatment according to the specific cause of the patient, so as to achieve precise treatment effect. In order to achieve precise control of drug release during treatment, the Controlled Drug Release System (CDDS) came into being and quickly became a research hotspot in the field of medicine. The drug controlled release system refers to the drug delivery mode in which carriers with different structures are used to carry the drug and control the quantitative r...

AI Technical Summary

Problems solved by technology

However, these works did not break away from the constraints of the original structure, the design freedom is not high, the improvement of the controlled release ability of the drug controlled release system is limited, and there is a large deviation between the optimized curve and the target curve.

At the same time, the research process mainly focuses on the cumulative amount of released drug, and also ignores the influence of the drug concentration distribution inside the cavity on the drug release law.

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