Benzothiazole derivative, preparation method thereof, corrosion inhibitor and cooling liquid
A technology of benzothiazole and derivatives, which is applied in the field of engines, can solve the problems of being unable to meet the requirements of anti-oxidation and corrosion of heavy vehicles and low performance, and achieve excellent high-temperature anti-oxidation and corrosion performance, good durability, and high-temperature anti-oxidation and corrosion performance Good results
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[0061] Another aspect of the present invention provides a method for preparing any one of the above-mentioned benzothiazole derivatives, comprising the following steps S100-S200.
[0062] Step S100, performing a substitution reaction between compound 1 and a monohalogenated saturated aliphatic carboxylic acid to obtain an intermediate M.
[0063] In some of these embodiments, the above substitution reaction is carried out in an alkaline environment. Further, an alkaline environment is provided by adding hydroxides of alkali metals.
[0064] After compound 1 is substituted with a monohalogenated compound of a saturated aliphatic carboxylic acid, intermediate M is produced, and acid is produced as a by-product. Carrying out in an alkaline environment neutralizes the by-product acid and facilitates the forward reaction to produce the intermediate M.
[0065] In some of these embodiments, in the above substitution reaction, an aqueous acetonitrile solution and a phase transfer c...
Embodiment 1
[0106] The structural formula of benzothiazolyl isooctanoic acid derivative A1 is as follows:
[0107]
[0108] Its preparation method is as follows:
[0109] (1) Add 0.01 mol of 2-mercapto-6-nitrobenzothiazole, 0.01 mol of chloroisooctanoic acid, 0.02 mol of sodium hydroxide, 0.2 g of PEG-4000, and 60 mL of acetonitrile aqueous solution with a volume fraction of 50% in a dry flask.
[0110] (2) Put it into an ultrasonic cleaner, set the temperature at 50°C-55°C, and react for 30 minutes. During the reaction, add water to the flask at any time to keep the liquid volume in the system constant.
[0111] (3) After the reaction is completed, adjust the pH value of the system to 3-4 with hydrochloric acid, then stand still, filter with suction, and wash the filter residue with cold water. Recrystallize the filter residue with 50% (V / V) ethanol aqueous solution, filter with suction, collect the filter residue to obtain intermediate M1, the structure is as follows:
[0112] ...
Embodiment 2
[0116] The structural formula of benzothiazolyl sebacic acid derivative A2 is as follows:
[0117]
[0118] Its preparation method is as follows:
[0119] (1) Add 0.01 mol of 2-mercapto-6-nitrobenzothiazole, 0.01 mol of chlorosebacic acid, 0.02 mol of sodium hydroxide, 0.2 g of PEG-4000, and 60 mL of acetonitrile aqueous solution with a volume fraction of 50% in a dry flask .
[0120] (2) Put it into an ultrasonic cleaner, set the temperature at 80°C-85°C, and perform a substitution reaction for 60 minutes. During the reaction, add water to the flask at any time to keep the liquid volume in the system constant.
[0121] (3) After the reaction is completed, adjust the pH value of the system to 3-4 with hydrochloric acid, then stand still, filter with suction, and wash the filter residue with cold water. Recrystallize the filter residue with 50% (V / V) ethanol aqueous solution, filter with suction, collect the filter residue to obtain intermediate M2, the structure is as fo...
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