Application of common turnip in resisting sleep deprivation injury

A technology of sleep deprivation and coriander root, which is applied in the application, medical preparations containing active ingredients, and the function of food ingredients, etc., can solve the problem of anti-sleep deprivation damage of coriander root extract, and achieve anti-sleep deprivation stress damage, Prevention and mitigation of sleep deprivation damage, effects of sleep deprivation stress damage

Active Publication Date: 2022-03-08
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the anti-sleep-deprivation-induced effects of coriander root extract have not been found

Method used

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  • Application of common turnip in resisting sleep deprivation injury
  • Application of common turnip in resisting sleep deprivation injury
  • Application of common turnip in resisting sleep deprivation injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the preparation of radish root water extract

[0037] The coriander root that the present invention adopts is planted in the eucalyptus in the east of the Qinghai-Tibet Plateau, with an average altitude of 4493.4m.

[0038] Cut coriander root into 3-5mm slices and air-dry in the shade for 2 weeks. According to the mass-volume ratio of coriander root and water as 1:8, heat to 100°C for reflux extraction for 2.5 hours, membrane filtration, and take the supernatant; repeat the extraction of the dregs once according to the above process to obtain the supernatant; The supernatants were combined and concentrated under reduced pressure until the solid content was 0.15 g / mL to obtain the root water extract, which was stored at -80°C for further experiments.

experiment example 1

[0039] Experimental example 1: Verification of anti-sleep deprivation injury of coriander root water extract

[0040] 1. Grouping of mice and their feeding conditions

[0041] The experiment was carried out after C57BL / 6J mice (22-25g) adapted to the experimental environment for one week. The animals were randomly divided into 6 groups (n=10): blank group (routine sleep), model group (SD), low-dose Diangen root group (1.0g / kg.bw.), middle-dose Diangen root group (2.0g / kg.bw. kg.bw.), coriander root high dose group (3.0g / kg.bw.), positive group (caffeine 10mg / kg.bw.). Dosage group is based on "Sichuan Provincial Tibetan Medicine Standards (2020)" (Sichuan Provincial Food and Drug Administration) in the conversion of the recommended dose (6g / d) for mice: the low dose of coriander root (equivalent to human 10 times the intake).

[0042] All experimental animal procedures were approved by the Ethics Committee of the Experimental Animal Center of Jiangnan University (application...

Embodiment 2

[0066] The composition of the present embodiment anti-sleep deprivation injury comprises 70 parts by weight of Radix Coriander root water extract, 30 parts by weight of Lycium barbarum water extract. The preparation method of coriander root water extract and wolfberry water extract is the same as in Example 1.

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PUM

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Abstract

The invention discloses application of common turnip in sleep deprivation injury resistance, and belongs to the technical field of special medical food. The common turnip is found to have the function of treating or preventing the sleep deprivation injury for the first time, has a good improvement effect on preventing and relieving the sleep deprivation injury, can well improve cognitive function and learning and memory impairment induced by sleep deprivation, has a good protection effect on hippocampus tissues, and can be used for treating sleep deprivation injury. And support is provided for development of novel SD-damage-resistant dietary nutrition supplements, functional foods with health-care effects and pharmaceutical compositions. Meanwhile, the invention also finds that the composition of the common turnip, the Chinese wolfberry, the ginseng, the codonopsis pilosula, the angelica sinensis and the dried tangerine peel has a synergistic effect on stress injury caused by sleep deprivation, and can play a greater role in resisting the stress injury caused by sleep deprivation.

Description

technical field [0001] The invention belongs to the technical field of special medical food, and in particular relates to the application of coriander root in resisting sleep deprivation damage. Background technique [0002] Sleep is essential for the proper functioning of the brain. But sleep deprivation (SD) is common in modern society. Insufficient sleep is associated with many sleep disorders, high workload, night shift work and jet lag. The Centers for Disease Control and Prevention (CDC) has declared sleep deprivation a "public health problem" and is recognized by the International Classification of Diseases (ICD) #307.49-4 as a sleep deprivation syndrome. Sleep deprivation can cause damage to the body's physiological and psychological functions, for example, it can cause stress damage such as cognitive function and memory impairment. Toxic effects on the central nervous system include disordered thinking, unresponsiveness, distraction, disorientation, impaired lear...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61K36/815A61K36/344A61K36/752A61P25/20A23L33/105
CPCA61K36/31A61K36/815A61K36/258A61K36/344A61K36/232A61K36/752A61P25/20A23L33/105A61K2236/331A61K2236/39A61K2236/51A61K2236/53A23V2002/00A61K2300/00A23V2200/322A23V2250/21A23V2250/2124Y02A50/30
Inventor 钱和朱红康化涵毅李兴鸣胡斌
Owner JIANGNAN UNIV
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