Near-infrared fluorescence two-photon fluorescent probe design aiming at real-time change of hydrogen peroxide in tumor process and synthesis method of near-infrared fluorescence two-photon fluorescent probe

Abstract

The invention belongs to the fields of molecular biology, medicine and the like, and particularly relates to a near-infrared two-photon fluorescence probe design aiming at real-time change of hydrogen peroxide in a tumor process and a synthesis method thereof. The structure of the fluorescent probe compound is shown as the following formula,

Description

Technical field [0001] The present invention belongs to the field of molecular biology, medicine, and more particularly to the present invention relates to a type of near-infrared biconi fluorescent fluorescence probe design and synthesis method thereof in real-time change in hydrogen peroxide during tumor. Background technique [0002] Fluorescence probes have been widely used in various fields such as biology, physiology, medicine and pharmacology. Many chemists and biologists also have a strong research interest in them. Based on the fluorescence probe detection method has many advantages, such as simple, low cost, high sensitivity, easy to adapt to automatic analysis, support space-resolved imaging, and providing a variety of signal output modes. More broadly, fluorescence sensors provide a unique way to detect important analytes for biological and / or environment and help to reveal physiological and pathological functions of these analytes. Compared to inorganic fluorescent...

AI Technical Summary

Problems solved by technology

But single-photon probes are limited in practical applications

The main reasons include: (1) short-wavelength excitation light limits the penetration depth in biological samples; (2) photobleaching, making the probe unsuitable for long-term imaging; (3) photodamage to biological samples; (4) interference from Autofluorescence of biological species with fluorescent signals

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