Preparation method of tetrahydrofolic acid
A technology of tetrahydrofolate and folic acid, applied in directions such as organic chemistry, can solve problems such as low yield of tetrahydrofolate preparation, and achieve the effects of overcoming large amount of catalyst, overcoming low yield and high catalytic efficiency
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[0033] The present invention provides a method of preparing a tetrahydrofulfuric acid, comprising the steps:
[0034] The PD / C catalyst and folic acid solution were added to the reactor, and hydrogen was charged into the reactor, and the reaction kettle was placed in an environment of 40-90 ° C, and the oxidation reaction of folic acid was oxidized with hydrogen. After the reaction, it was tetrahydrogen. Folic acid;
[0035] The reaction equation for preparing tetrahydrate acid is as follows:
[0036]
[0037] Among them, the chemical formula of solid folic acid is:
[0038] The chemical formula of tetrahydrofolate is:
[0039] The present invention has been prepared by catalytic reduction of folic acid in catalyst PD / C to obtain tetrahydrofluolic acid, and the catalyst PD / C is high and can be recycled, and the prior art has a low amount of catalyst or low yield.
[0040] The carbonaceous nitrogen bonds in the hydrogen reducing folic acid, specifically hydrogen adsorptio...
Embodiment 1
[0065] After environment at 25 deg.] C, was added 1g of solid folic acid in 100mL three-necked flask, the flask was replaced with nitrogen three times, was added to the flask in 10mL 0.2mol / L pH of the NaH 7 2 PO 4 -Na 2 HPO 4 Buffer solution, stirred until homogeneous, to give a mixed solution, pH adjusted solution was mixed with 20% NaOH solution to 7 to obtain a solution of folic acid;
[0066] After addition of 0.1g10% Pd / C to a 50mL autoclave, the autoclave was replaced with nitrogen three times, was added to the kettle pH 7 solution of folic acid, the autoclave was replaced with hydrogen five times, the autoclave filled with hydrogen, the reaction pressure was adjusted to 50bar, the reactor was placed under 60 ℃ environment, redox reactions, 15H reaction, after the reaction, to give a solution containing folate, comprises using 1mol / L hydrochloric acid solution after the pH of the solution to 3 tetrahydrofolate, tetrahydrofolate deposited precipitate, the precipitate w...
Embodiment 2
[0069] After setting at 28 ℃, folic acid was added 1g of solid 100mL three-necked flask, the flask was replaced with nitrogen three times, was added to the flask in 10mL 0.2mol / L pH of the NaH 7 2 PO 4 -Na 2 HPO 4 Buffer solution, stirred until homogeneous, to give a mixed solution, pH adjusted solution was mixed with 20% NaOH solution to 7 to obtain a solution of folic acid;
[0070] After addition of 0.2g10% Pd / C to a 50mL autoclave, the autoclave was replaced with nitrogen three times, was added to the kettle pH 7 solution of folic acid, the autoclave was replaced with hydrogen five times, the autoclave filled with hydrogen, the reaction pressure was adjusted to 30bar, the reactor was placed under the environment of 70 deg.] C, oxidation reduction reaction, the reaction 15H, after the reaction, to give a solution containing folate, comprises using 1mol / L hydrochloric acid solution after the pH of the solution to 3 tetrahydrofolate, tetrahydrofolate deposited precipitate, ...
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