Preparation method of 2-methyl-5-(1-methylpyrrolidine-2-yl) pyridine

Abstract

The invention relates to a preparation method of 2-methyl-5-(1-methylpyrrolidine-2-yl) pyridine, the 2-methyl-5-(1-methylpyrrolidine-2-yl) pyridine is prepared by taking 6-methyl nicotinate as a raw material, and the preparation route is as follows: R1 is alkyl with 1-4 carbon atoms, such as methyl, ethyl, propyl or butyl; r2 is hydrogen, methyl or ethyl; m is Na, K or Li. According to the preparation method, the raw materials are easy to obtain, the purity and the yield can meet the industrial production requirements, compared with nicotine racemate, the obtained product 2-methyl-5-(1-methylpyrrolidine-2-yl) pyridine has better sensory test data, when the electronic cigarette atomized liquid is prepared, the effect of 3 mg / ml of natural nicotine can be achieved with the dosage of 1.5 mg / mL, and sensory experience is good.

Description

technical field [0001] The invention relates to the field of organic synthesis, in particular to a preparation method of 2-methyl-5-(1-methylpyrrolidin-2-yl)pyridine. Background technique: [0002] In recent years, with the advancement of science and technology, domestic tobacco companies have continuously promoted the development of new tobacco products. Among them, electronic cigarettes, as an extremely important form of new tobacco, have experienced explosive growth, while nicotine (commonly known as nicotine) , as the core functional ingredient of the entire e-cigarette industry, the demand is increasing day by day. [0003] At present, most of the nicotine sold on the market is mainly extracted from tobacco, but the output is seriously affected by external factors such as climate, tobacco raw material output, growth cycle, etc., and the nicotine extracted from tobacco will inevitably contain masmin, The components such as neonicotinoid, dehydroneonicotinoid, and nitros...

AI Technical Summary

Problems solved by technology

[0003] At present, most of the nicotine sold on the market is mainly extracted from tobacco, but the output is seriously affected by external factors such as climate, tobacco raw material output, growth cycle, etc., and the nicotine extracted from tobacco will inevitably contain masmin, Neonicotinoid, dehydroneonicotinoid, nitrosamine and other components are extracted at the same time, which is extremely difficult to remove and has potential danger to human health

[0004] In the preparation method of artificially synthesized nicotine, racemic nicotine contains nicotine in two configurations R and S. In order to achieve the effect of extracting nicotine from natural tobacco, chiral resolution is required to retain the psychoactive isomer S-nicotine. , resulting in low yield and high cost

[0005] For this reason, some researchers introduced arecoline and other plant-derived alkaloids for application attempts, but they still could not achieve the ideal sensory experience

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