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Composition for treating hepatitis-cholangitis overlap syndrome by using Yunnan paris polyphylla as main raw material as well as preparation method, preparation and application of composition

A technology for cholangitis and syndrome, applied in the field of medicine, can solve the problems of inability to reduce the incidence of end-point events, obvious side effects, and no obvious benefit in the long-term survival rate of patients

Active Publication Date: 2022-03-22
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have no significant benefit on the long-term survival rate of patients, cannot reduce the incidence of end-point events, and have obvious side effects and poor patient compliance

Method used

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  • Composition for treating hepatitis-cholangitis overlap syndrome by using Yunnan paris polyphylla as main raw material as well as preparation method, preparation and application of composition

Examples

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preparation example Construction

[0023] The preparation method of the composition for treating hepatitis-cholangitis overlap syndrome using Rhizoma yunnanensis as the main raw material of the present invention includes pretreatment, decoction extraction, alcohol extraction and posttreatment steps, specifically including:

[0024] A. Pretreatment: Weigh and mix each raw material according to the formula ratio to obtain material a;

[0025] B. Decoction and extraction: add water 8 to 12 times the mass of material a to material a, decoct and extract 1 to 3 times at a temperature of 90 to 100 ° C, each time for 1 to 2 hours, combine the extracts, and concentrate the relative density of the extracts 1.10~1.20 (60°C) to obtain material b;

[0026] C. Add ethanol to the material b until the alcohol content is 65~75%, stir it evenly and let it stand overnight, filter off the precipitate, recover the ethanol from the filtrate and concentrate it to a clear paste with a relative density of 1.10~1.25 (60°C). After the o...

Embodiment 1

[0031] Take 1000g capillary root, 1000g red peony, 300g scorpion, 500g chrysanthemum, 1000g green bark, 1500g woody root, 2000g smilax smilax, 1000g white fresh bark, 1000g malt, 500g licorice, mix well, add 57Kg of water, and set the temperature at 90 Decoct and extract once at ~95°C for 2 hours, combine the extracts, and concentrate the extracts with a relative density of 1.20 (60°C); add ethanol until the alcohol content is 75%, stir well, let stand overnight, and filter out the precipitate The ethanol was recovered from the filtrate and concentrated to a clear ointment with a relative density of 1.25 (60°C). The clear ointment was dried to obtain a composition for the treatment of hepatitis-cholangitis overlap syndrome with the main raw material of Yunnan Chonglou.

Embodiment 2

[0033] Take 2500g of capillary root, 3000g of red peony, 1500g of scorpion, 2000g of chrysanthemum, 2000g of green skin, 2000g of woody fragrance, 3000g of smilax, 2500g of white fresh skin, 3000g of malt, 1500g of licorice, mix well, add 208Kg of water, and put it at a temperature of 95 Decoction and extraction at ~100°C for 3 times, 1 hour each time, combine the extracts, the relative density of the concentrated extracts is 1.10 (60°C); add ethanol until the alcohol content is 65%, stir well, let stand overnight, and filter out the precipitate The ethanol was recovered from the filtrate and concentrated to a clear ointment with a relative density of 1.10 (60°C). After the clear ointment was dried, a composition for treating hepatitis-cholangitis overlap syndrome was obtained with the main raw material of Zhonglou Yunnan.

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Abstract

The invention discloses a composition for treating hepatitis-cholangitis overlap syndrome by using Yunnan paris polyphylla as a main raw material as well as a preparation method, a preparation and application of the composition. The composition for treating the hepatitis-cholangitis overlap syndrome by taking the Yunnan rhizoma paridis as the main raw material is prepared from the following raw materials in parts by weight: 1000 to 2500 parts of herba artemisiae scopariae, 500 to 1500 parts of rhizoma paridis, 1000 to 3000 parts of radix paeoniae rubra, 300 to 1500 parts of scorpio, 1000 to 2000 parts of pericarpium citri reticulatae viride, 1000 to 2000 parts of radix aucklandiae, 1000 to 3000 parts of rhizoma smilacis glabrae, 1000 to 2500 parts of cortex dictamni, 1000 to 3000 parts of malt and 500 to 1500 parts of liquorice root. The preparation can be granules, tablets, capsules, oral solutions and syrups. The application refers to the application of the composition for treating the hepatitis-cholangitis overlap syndrome by taking the Yunnan paris polyphylla as the main raw material in preparing a medicine for treating the hepatitis-cholangitis overlap syndrome.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a composition for treating hepatitis-cholangitis overlap syndrome with polyphylla yunnanensis as the main raw material, as well as its preparation method, preparation and application. Background technique [0002] Autoimmune hepatitis-primary biliary cholangitis (AIH-PBC) overlap syndrome is a severe progressive disease associated with the mediation of abnormal autoimmune responses, the etiology and pathogenesis of which are not well understood. Epidemiological investigations have shown that AIH-PBC overlap syndrome recurs, persists, and the incidence rate increases year by year. Patients can rapidly progress to liver cirrhosis and liver failure, or develop fulminant or subfulminant liver disease. Studies have shown that in the treatment of AIH-PBC, traditional Chinese medicine has a unique effect on liver function, improvement of symptoms, and improvement of curati...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61K36/90A61P1/16A61P37/02A61K36/896A61K35/646
CPCA61K36/282A61K36/896A61K36/71A61K36/65A61K35/646A61K36/752A61K36/285A61K36/90A61K36/75A61K36/8998A61K36/484A61P1/16A61P37/02A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2300/00Y02A50/30
Inventor 浦仕彪李维蛟郑国伟李文春郝俊杰张祎
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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