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Method for simultaneous quantitative analysis of travoprost and travoprost acid contained in solution sample

A technology of travoprost acid and travoprost is applied in the field of pharmacokinetic research to achieve the effects of improving detection sensitivity, high sensitivity and stable matrix effect

Pending Publication Date: 2022-04-08
SHENYANG XINGQI PHARM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] In the prior art, there is no report on the method for simultaneous quantitative analysis of travoprost and travoprost acid contained in a solution sample, especially after adding an enzyme inhibitor to a biological sample, the simultaneous rapid determination of the sample solution There is no literature report on the bioanalysis method of travoprost and travoprost acid in

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  • Method for simultaneous quantitative analysis of travoprost and travoprost acid contained in solution sample
  • Method for simultaneous quantitative analysis of travoprost and travoprost acid contained in solution sample

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[0106] The invention and its advantages will be described in detail below by means of exemplary embodiments. The description of the exemplary embodiments is illustrative only, and in no way serves as any limitation of the disclosure, its application or uses. The present disclosure can be implemented in many different forms and is not limited to the embodiments described here. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art. It should be noted that unless otherwise stated, the relative arrangement of components and steps, material composition, numerical expressions and numerical values, etc. set forth in these embodiments should be interpreted as merely exemplary and not limiting.

[0107] Materials and instruments used:

[0108] Animal: New Zealand rabbit, weighing about 1.5 to about 2.5 kg, commercially purchased from Qingdao Kangda Biotechnology Co., ...

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Abstract

The invention discloses a method for simultaneously performing quantitative analysis on travoprost and travoprost acid contained in a solution sample. The method is characterized in that the quantitative analysis is performed by adopting a high performance liquid chromatography-tandem mass spectrometry technology. The method disclosed by the invention has the advantages of simplicity and convenience in operation, sensitivity, rapidness, high specificity, strong specificity, high accuracy, good reproducibility and short analysis time. By adopting the method disclosed by the invention, a chromatogram with satisfactory sample peak shape and chromatographic retention time can be obtained, and particularly, the travoprost and the active metabolite travoprost acid of the travoprost in a biological tissue sample added with an enzyme inhibitor can be quantitatively analyzed at the same time; therefore, the influence of the enzyme inhibitor on the conversion rate of travoprost can be calculated.

Description

technical field [0001] The invention relates to the field of pharmacokinetic research. Specifically, the present invention relates to a method for quantitatively analyzing a drug in a solution sample, and more particularly, the present invention relates to a method for simultaneously performing quantitatively analyzing travoprost and travoprost acid contained in a solution sample. Background technique [0002] Travoprost is a prostaglandin F2α analog that can be used to treat open-angle, angle-closure glaucoma and ocular hypertension. It is a highly selective and high affinity full agonist of the prostaglandin FP receptor, which reduces intraocular pressure by increasing aqueous humor outflow through the uveoscleral pathway. It is the ester prodrug of travoprost acid (travoprost acid isopropyl ester), absorbed through the cornea, it can be hydrolyzed into biologically active free travoprost acid quickly by corneal esterase, and Play its role in lowering eye pressure. The ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72G01N30/06
Inventor 刘继东杨强赵欣王小桐祖嶶
Owner SHENYANG XINGQI PHARM CO LTD
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