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Application of receptor QSOX1 capable of promoting osteogenesis

A receptor and osteogenesis technology, which can be used in medical preparations containing active ingredients, bone diseases, peptide/protein components, etc. It can solve problems such as the application of QSOX1 that no one has paid attention to, and achieve the effect of promoting osteogenesis.

Pending Publication Date: 2022-04-12
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far no one has paid attention to the application of QSOX1 in the direction of osteogenesis

Method used

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  • Application of receptor QSOX1 capable of promoting osteogenesis
  • Application of receptor QSOX1 capable of promoting osteogenesis
  • Application of receptor QSOX1 capable of promoting osteogenesis

Examples

Experimental program
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Effect test

Embodiment 1

[0022] (1) Experimental method

[0023] ①Construction of recombinant expression vector and expression of target protein

[0024] The human QSOX1 gene (NCBI reference sequence: NM_001004128.3) was synthesized by Jinweizhi Biological Company after codon optimization. Such as figure 1 所示,PCR获得了人源QSOX11 cDNA片段(对应蛋白序列MRRCNSGSGPPPSLLLLLLWLLAVPGANAAPRSALYSPSDPLTLLQADTVRGAVLGSRSAWA VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRF FKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNNE EYLALIFEKGGSYLGREVALDLSQHKGVAVRRVLNTEANVVRKFGVTDFPSCYLLFRNGSV SRVPVLMESRSFYTAYLQRLSGLTREAAQTTVAPTTANKIAPTVWKLADRSKIYMADLESA LHYILRIEVGRFPVLEGQRLVALKKFVAVLAKYFPGRPLVQNFLHSVNEWLKRQKRNKIPYS FFKTALDDRKEGAVLAKKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEA ​​AKAKEVLPAIRGYVHYFFGCRDCASHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARL AGAPSEDPQFPKVQWPPRELCSACHNERLDVPVWDVEATLNFLKAHFSPSNIILDFPAAGSA ARRDVQNVAAAPELAMGALELESRNSTLDPGKPEMMKSPTNTTPHVPAEGPEASRPPKLHP GLRAAPGQEPPEHMAELQRNEQEQPLGQWHLSKRDTGAALLAESRAEKNRLWG...

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Abstract

The invention relates to application of a receptor QSOX1 capable of promoting osteogenesis, experiments prove that the QSOX1 can be used as the receptor to be combined with secreting type DDRGK1 to play a role in treating fracture or bone defect, a new thought is opened for treatment of bone related diseases, and further clinical application of receptor regulation is expanded.

Description

technical field [0001] The invention belongs to the field of bone-related diseases, in particular to the application of a receptor QSOX1 that can promote osteogenesis. Background technique [0002] At present, the treatment of bone-related diseases is mostly surgical treatment, but the excessive trauma of surgery often leads to delayed union and nonunion of fractures, and there is often a lack of effective osteogenesis promotion programs for this situation. Not only that, for osteoporosis, often only drugs can be used to inhibit osteoclastosis, but there is a lack of prevention and treatment methods to promote osteogenesis and increase bone mass. [0003] DDRGK1 is considered to be an important protein involved in the ubiquitination process. It is involved in apoptosis caused by endoplasmic reticulum stress [Wu J, Lei G, Mei M, et al. A novel C53 / LZAP-interacting protein regulates stability of C53 / LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF -kapp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P19/08
Inventor 赵杰杨骁周唐峻夏莹戎柯纬曹贤坤秦安曹禹
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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