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Anticancer MnO2 targeted liposome, micro-nano bubble and freeze-dried powder for identifying benign and malignant tumors

A technology for targeting liposomes and micro-nano bubbles, which is applied in the field of medical supplies to achieve the effects of improving bioavailability, increasing stability, and simple and non-invasive identification methods.

Pending Publication Date: 2022-04-12
SHENZHEN PKU HKUST MEDICAL CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the prior art, there is no anti-cancer drug that can easily, safely and efficiently identify the cancerous state of tumors, and has anti-tumor functions at the same time.

Method used

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  • Anticancer MnO2 targeted liposome, micro-nano bubble and freeze-dried powder for identifying benign and malignant tumors
  • Anticancer MnO2 targeted liposome, micro-nano bubble and freeze-dried powder for identifying benign and malignant tumors

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Embodiment Construction

[0038] see figure 1 , the anti-cancer MnO disclosed in this application for differentiating benign and malignant tumors 2 Targeting micro-nanobubbles, including lipid membrane coating10, Mn0 2 Solution contents 20 and cRGD(30). Mn0 2 The solution content 20 is encapsulated within the lipid film coating 10 on which the cRGD ( 30 ) is disposed. Mn0 2 Ce6(40) and inert gas 50 are also present in the solution content 20 . The lipid film coating 10 comprises an outer film 110, a connecting layer 120 and an inner film 130; the connecting layer 120 is arranged between the outer film 110 and the inner film 130 for connecting the outer film 110 and the inner film 130 .

[0039] Wherein: lipid film coating 10 is encapsulated in Mn0 by self-assembly 2 The exterior of the solution content 20, capable of releasing MnO in response to low-frequency ultrasonic cavitation effects 2 solution and Ce6(40); MnO 2 Capable of interacting with H in acidic environments 2 o 2 Generate Mn 2+...

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Abstract

The invention belongs to the technical field of medical supplies, and particularly relates to anticancer MnO2 targeted liposome, micro-nano bubbles and freeze-dried powder for benign and malignant tumors. The invention relates to an anticancer MnO2 targeted micro-nano bubble for benign and malignant tumors. The anticancer MnO2 targeted micro-nano bubble is characterized by comprising a lipid membrane coating and a MnO2 solution content, wherein the lipid membrane coating can respond to a low-frequency ultrasonic cavitation effect to release a MnO2 solution; mnO2 and H2O2 in an acidic environment can generate Mn < 2 + > and singlet oxygen 1O2. The anticancer MnO2 targeted liposome and micro-nano bubble for benign and malignant tumors, provided by the invention, have the technical effects of safety, noninvasive property, high efficiency, low medical cost and the like.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and in particular relates to anticancer MnO for differentiating benign and malignant tumors 2 Targeted liposomes, micronanobubbles and lyophilized powders. Background technique [0002] Manganese dioxide (MnO 2 ) As a new type of two-dimensional material, it is a newly discovered super material with the most biological application potential in recent years. Manganese dioxide nanosheets have good biocompatibility and in vivo degradability. MnO 2 Nanosheets have a large specific surface area and strong adsorption. It has been confirmed many times that they can be used as carriers for small molecular substances such as sound sensitizer Ce6 and drugs such as doxorubicin. In addition MnO 2 It has broad absorption in the ultraviolet and infrared regions and high photothermal conversion efficiency, and has been used in photoacoustic imaging, photothermal therapy, and sonodynamic therapy. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06A61K49/10A61K49/18A61K41/00A61K33/32A61K9/19A61P35/00A61K49/22
Inventor 郑婷婷陈芸帅心涛王梦欣林淑萍罗岚姚荣权曹众胡会英
Owner SHENZHEN PKU HKUST MEDICAL CENT
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