166 results about "Low frequency ultrasound" patented technology

The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused.

The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused.

The invention relates to a targeted drug-bearing ultrasonic microbubble comprising a lipide dimolecular layer outer shell, targeted polypeptide fixed at the outer side of the lipide dimolecular layer outer shell, a biological inert gas wrapped in the lipide dimolecular layer outer shell and medicament granules dispersed in the lipide dimolecular layer outer shell. The targeted polypeptide is a polypeptide or protein derivative containing an amino acid sequence CGNKRTRGC. By connecting the polypeptide or protein derivative containing a tumor targeted peptide sequence outside the lipide dimolecular layer outer shell, the obtained targeted drug-bearing ultrasonic microbubble can target the lymph vessels and the tumor cells of a tumor, can detect and diagnose the generation, the development and the curative effect on the tumor in real time through high-frequency ultrasonic imaging and can crush the microbubble through low-frequency ultrasound to release the medicament granules so as to achieve the aim of controllably and targetedly releasing the medicament, thereby having extremely important meanings to the prevention, diagnose and treatment of the tumor. In addition, the invention also relates to a preparation method of the targeted drug-bearing ultrasonic microbubble.

Methods and devices for producing cavitation in tissue are provided. In one embodiment, a low-frequency ultrasound pulse is transmitted into tissue, a high-frequency ultrasound pulse is transmitted into tissue, and a composite waveform is formed in the tissue that has a peak negative pressure value that exceeds an intrinsic threshold for cavitation in the tissue. In some embodiments, the peak negative pressures of the individual ultrasound pulses do not exceed the intrinsic threshold for cavitation. In another embodiment, a plurality of ultrasound pulses at various resonant frequencies are transmitted into tissue, and the time delays between these transmissions are adjusted to allow the ultrasound pulses to align temporally and form a monopolar pulse having a compound peak negative pressure that exceeds an intrinsic threshold for cavitation in the tissue. Systems for performing Histotripsy therapy are also discussed.

A method for improving the unfreezing quality of fast frozen fruit and vegetables with low-frequency ultrasonic belongs to the processing technical field of fruit and vegetable food. The present invention adopts ultrasonic for freezing in the process of fast freezing; the process is that the raw materials of fruit and vegetables are selected, cleaned and burnt to kill the enzyme; and then the materials are cooled, refrigerated and frozen with ultrasonic; at last the materials are packed up. The present invention adopts the process that the ultrasonic processing is combined in the process of dipping and freezing fruit and vegetable and improves the unfreezing quality of the fast frozen fruit and vegetables; the present invention is characterized by a short freezing time, excellent initial shape maintenance and low operational cost.

An apparatus and methods for diagnosing and treating nerve compression conditions in a patient, such as carpal tunnel syndrome, tarsal tunnel syndrome and other nerve compression conditions. Ultrasound transducer heads having an array of high frequency piezoelectric crystal elements mounted in the transducer head capable of delivering frequencies of 7.5 MHz or greater, and a low frequency piezocomposite element mounted in the transducer head capable of delivering frequencies of 0.25 MHz to 1.5 MHz at an intensity of about 0.25 W / cm2 to 2.0 W / cm2 can be used to diagnose and also treat the conditions. If necessary, the high frequency piezoelectric elements can be used to visualize the region of therapy to more accurately direct the low frequency ultrasound energy.

Arrangements are provided for destroying tumor cells. According to one aspect, an arrangement includes a device having at least one high-frequency ultrasound generator for generating a thermally active, high-frequency oscillation, a plurality of first low-frequency ultrasound generators for generating a therapeutically active low-frequency oscillation, wherein the first low-frequency ultrasound generators each generate a different frequency, and a control system connected to the high-frequency ultrasound generator and to the first low-frequency ultrasound generators in such a way that the tumor cells are subjected to a high-frequency oscillation acting thermally on the tumor cells and to a low-frequency oscillation. The arrangement further includes a biopsy device having a plurality of individual receivers for tissue samples and a plurality of second low-frequency ultrasound generators operatively connected to the individual receivers for subjecting the tissue samples to an oscillation, wherein oscillations with the same frequency can be generated respectively by first and second low-frequency ultrasound generators.

The invention discloses a Bernoulli twisted-pair low-frequency ultrasonic triple atomizing spray nozzle. The overall vibrating direction of the spray nozzle is an axial direction. An amplitude-change pole of the Bernoulli twisted-pair low-frequency ultrasonic triple atomizing spray nozzle is a twisted-pair composite amplitude-change pole. A metal for making the Bernoulli twisted-pair composite amplitude-change pole is small in size and generates little heat, so that the defects of large metal sizes and large heat generation amounts of a conical amplitude-change pole and a stepped amplitude-change pole are overcome; by adopting the Bernoulli twisted-pair low-frequency ultrasonic triple atomizing spray nozzle disclosed by the invention, fog drops undergo triple atomization on the right end face of a metal sheet under the wind power action of a fan on an air inlet pipeline, so that the defect of difficulty in generating ultrafine fog drops in low-frequency ultrasonic atomization is overcome; the spray nozzle can be applied to the fields of atomizing cultivation, ultrasonic spraying and the like.

The invention provides a dual-frequency intravascular ultrasound imaging probe. The probe comprises a low-frequency ultrasound transducer and a high-frequency ultrasound transducer for simultaneouslyor separately transmitting ultrasound to conduct imaging, and the two ultrasound transducers are connected through the same coaxial cable. According to the probe, a low-frequency single-array-elementtransducer and a high-frequency single-array-element transducer are adopted, excitation signals can be simultaneously or separately transmitted to the two transducers when the probe is operated, so that the transducers perform ultrasound transmission or receiving, and low-frequency and high-frequency ultrasound images can be obtained simultaneously by subsequently conducting processing such as filtering and the like on signals received by the transducers. In addition, two transducers are adopted while only one coaxial cable is adopted, compared with a single-array-element mechanical guiding tube, the size of the probe is not increased, and only a rotary withdrawal device and a signal port are needed at the tail part of the guiding tube.

The present invention refers to an ultrasonic device comprising an ultrasound transducer; and a disk-shaped metallic low-frequency ultrasound (NFLUS) resonator being mechanically connected with the ultrasound transducer on one side of the resonator; a container with an opening on its bottom side and being arranged on the other side of the disk-shaped resonator such that the opening is facing the disk-shaped resonator; an elastic sealing element arranged between the disk-shaped resonator and the container for sealing the container around the opening; and means for supplying a pressing force such that the container is tightened on the resonator during ultrasonication, but can be can be repeatedly disassembled and assembled after ultrasonication.

The invention relates to a complex frequency focused ultrasound non-invasive fat dissolving method and device. The invention is characterized in that low frequency ultrasound and medium high frequency high-power focused ultrasound are comprehensively applied to act on subcutaneous fat simultaneously, a mode of dissolving the subcutaneous fat by complex frequency is utilized, and long-time low frequency low-power ultrasound stably performs ultrasound cavitation in subcutaneous fat cells, thus interior tension accumulation is close to a critical threshold; because the medium high frequency high-power focused ultrasound waves which are instantly transmitted can focus the ultrasound waves within an accurate focusing range, the ultrasound waves can selectively act on the subcutaneous fat cells without damaging the surrounding tissues; and the medium high frequency high-power focused ultrasound waves which are transmitted instantly can induce instant unstable ultrasound wave cavitation under the condition that the stable cavities in the subcutaneous fat cells are close to the critical threshold, and explosion is induced in the subcutaneous fat cells to promote the subcutaneous fat cells to dissolve.

A method of detecting cellular damage within a subject comprises transmitting low frequency ultrasound (20 MHz or below) into a selected site within the subject wherein the selected site has been exposed to a stress capable of causing cellular death at the selected site. At least a portion of ultrasound backscattered from the ultrasound transmitted into the selected site is received. The received backscattered ultrasound is compared to a control backscatter measurement. An increase or a decrease in intensity or spectral slope of the received backscattered ultrasound when compared to the control backscatter measurement indicates cellular death or damage at the selected site within the subject.

The invention discloses a low-frequency ultrasonic secondary atomizing sprayer with an adjustable spray angle of an ultrasonic atomizer. A nozzle is provided with a liquid inlet hole, the liquid inlet hole is communicated with one end of a liquid outlet hole, the tail end of the nozzle is a trapezoid nozzle groove, a trapezoid secondary atomizing active cell is arranged at the trapezoid nozzle groove, and the other end of the liquid outlet hole is communicated with the trapezoid nozzle groove; an adjusting screw penetrates the trapezoid secondary atomizing active cell and is connected with the secondary atomizing active cell and the nozzle by virtue of screw threads; the adjusting screw is provided with a balance spring, one end of the balance spring is supported on the tail end face of the trapezoid secondary atomizing active cell, and the other end of the balance spring is supported on the tip of the adjusting screw; and a distance between the trapezoid nozzle groove and the trapezoid secondary atomizing active cell is 0-1mm. The adjustable trapezoid secondary atomizing active cell is adopted, thus the regulating range of fog drop size is increased, the nozzle can regulate the fog drop size at any position by virtue of the balance spring, and a mounting angle is flexible.

Improved devices, systems, and methods treatment of patients can be used to help mitigate injury to the kidneys by applying cyclical mechanical pressure energy at low intensities. The energy often be selectively directed from non-invasive transducers disposed outside the patients. The energy will typically comprise low frequency ultrasound energy, shock wave energy, or the like, and may induce the generation and / or release of nitric oxide, thereby enhancing perfusion and ameliorating tissue damage. Superimposed micro and macro duty cycles may help avoid thermal and other injury to tissues of the patient during treatment. Bilateral treatments are facilitated by a support structure that orients at least one transducer toward each kidney.

The invention relates to an ultrasonic imaging device and method. The device comprises a motion control platform used for controlling the image scanning path, an amplitude modulation ultrasonic transmitting system used for transmitting ultrasonic excitation signals, a data acquiring and processing system used for receiving and processing echo signals, a computer imaging and displaying system used for reconstruction imaging of echo signals which are fed back, and an ultrasonic transducer used for sending and receiving ultrasonic waves acting on a phantom. The device and method have the advantages that more contrast medium microbubbles are adsorbed by the vascular wall through radial force generated after the amplitude modulation ultrasonic transmitting system acts on low-frequency ultrasound transmitted by the ultrasonic transducer, the imaging signal intensity of tissue is improved, high-resolution ultrasonic imaging is achieved through a high-frequency component, the imaging resolution ratio and the imaging depth are both considered, and a clearer image is provided for ultrasonic diagnosis.

The invention is to a biomedical used multiple-channel hemispherical focused ultrasound phased array apparatus. The invention comprises of a graphic user interface, digital multiple channel phase control kernel, multiple channel driving system, and impedance matching module, power feedback device, as well as the hemispherical low-frequency ultrasound phased array. The invention also serves as a good platform reference to develop a focused ultrasound system in the assisted brain drug delivery application.

The invention relates to a dual-channel ultrasonic attenuation signal detection device. Ultrasonic attenuation signals received by two receiving ultrasonic transducers of the device are converted into DC signals capable of being collected by an A / D (Analog-to-Digital) converter through a logical control circuit, a cascade amplifying circuit and an AC modulation circuit. The ultrasonic attenuation signal detection accuracy of the device is not less than 0.1 dB, the ultrasonic attenuation signal detection capacity is in a dynamic range of 94 dB, and thus, the detection accuracy on pulp density and particle size for an ultrasonic online particle size analyzer is increased.

The invention discloses a high-accuracy anti-interference ultrasonic wind speed and wind direction measuring method. The method comprises the following steps of: adopting eight ultrasonic probes with an ultrasonic receiving and transmitting function including four high-frequency ultrasonic probes and four low-frequency ultrasonic probes, which are arranged oppositely in pairs to form two sets of low-frequency ultrasonic probe pairs TD12 and TD34 and two sets of high-frequency ultrasonic probes TD56 and TD78; respectively acquiring the propagation time of ultrasonic waves which are transmittedfrom opposite sides and received by the two probes in each probe pair; and according to the measured propagation time and the distance between the two face-to-face probes in each ultrasonic probe pair, acquiring the three-dimensional wind speed and wind direction of natural wind. By using the method, the measured three-dimensional wind speed and wind direction can be accurately calculated, ultrasonic waves with two frequencies can be selected to measure the wind speed and wind direction, and the anti-interference capacity of a wind measuring device is improved, so the method is applicable to all-weather wind speed and wind direction measurement under severe environment conditions.

The invention discloses a cissoid line type low-frequency ultrasonic three-time atomizing spray head. The overall vibration direction of the spray head is an axial direction. The cissoid line type low-frequency ultrasonic three-time atomizing spray head has the benefits that the cissoid line type low-frequency ultrasonic three-time atomizing spray head adopts a cissoid line type composite amplitude transformer; the cissoid line type composite amplitude transformer has small metal volume and less heating and overcomes the defect that a conical amplitude transformer and a ladder-shaped amplitude transformer have large metal volume and more heating; through the cissoid line type low-frequency ultrasonic three-time atomizing spray head, under the wind force action of a fan at an air inlet pipe, fog drops are subjected to tertiary atomization on the right end surface of a metal sheet, so that the defect that ultra-fine fog drops are hard to generate by low-frequency ultrasonic atomization is overcome; the cissoid line type low-frequency ultrasonic three-time atomizing spray head can be used for atomization cultivation, ultrasonic spraying and other fields.

The invention discloses a preparation method of a zinc-enriched liquid fermentation product of phellinus linteus. The preparation method comprises the following steps: inoculating a phellinus linteus strain onto a liquid seed culture medium added with zinc-enriched yeast and a diaphragma juglandis extract, rapidly culturing with the help of a low-frequency ultrasound with a certain frequency and intensity, inoculating the phellinus linteus liquid strain onto a liquid fermentation culture medium added with zinc-enriched yeast and a plukenetia volubilis leave enzymolysis product and culturing in an ultra-low-frequency magnetic field with a certain frequency and intensity to obtain the zinc-enriched liquid fermentation product of phellinus linteus. According to the preparation method, by the physical-assisted synergistic fermentation of seed liquid and fermentation two-phase low-frequency ultrasound and ultra-low-frequency magnetic fields and the synergistic effect of exogenous additives such as the diaphragma juglandis extract and the plukenetia volubilis leave enzymolysis product, the contents and activities of organic zinc and zinc polysaccharide in final fermentation product of phellinus linteus are significantly increased.

The invention discloses a device and a method for extracting V<E> (vitamin E) in an enhanced manner by means of ultrasonically pre-treating deodorized and distilled products of plant oil, and relates to the field of extraction technologies for natural V<E>. The method includes steps of (1), ultrasonically pre-treating the deodorized and distilled products of the plant oil at low frequencies; (2), performing quick cold precipitation on sterol; (3), performing distillation separation. The external circulating serial connection device for extracting the V<E> in the enhanced manner by means of ultrasonically pre-treating the deodorized and distilled products is independent and is serially connected with an ester exchange reaction procedure for generating biodiesel and a cold precipitation crystallization procedure for the sterol of distilled products, so that different requirements of conversion or crystallization of deodorized products and the distilled products on environmental conditions can be met, the ether exchange conversion time can be shortened, reaction can be carried out continuously, and the usage of catalysts can be reduced. The device and the method have the advantages that the V<E> can be extracted in a separation manner by means of distillation separation; the solvents such as ethanol in an ether exchange reaction tank and a cold precipitation reaction tank can be recycled by an ethanol recycling / reusing device; a technology of the method is simple, the V<E> extraction time can be greatly shortened, and impurities can be reduced; the V<E> can be produced continuously, and sterol and biodiesel products with high quality can be acquired.

A minimally invasive, dynamic and continuous detection method for human blood glucose concentration, including: firstly, using low-frequency ultrasound for the pretreatment on skin; secondly, extracting human tissue fluid from the skin after the low-frequency ultrasound pretreatment under the vacuum negative function; thirdly, detecting the skin impedance / resistance during the permeable skin tissue liquid extraction process; fourthly, measuring the glucose concentration of the extracted human tissue liquid; fifthly, using the skin impedance / resistance to determine the extracted tissue liquid volume and to establish the prediction model of the correlation between the glucose concentration in the tissue liquid and the glucose concentration in blood; sixthly, obtaining the human blood glucose concentration according to the skin impedance / resistance that is measured in the third step, the glucose concentration of the human tissue liquid that is measured in the fourth step and the prediction model that is established in the fifth step. The invention can realize the minimally invasive, dynamic and continuous detection method for the human blood glucose concentration and has the advantages of high measurement resolution and precision, good stability of the measured result, small tissue liquid amount to be measured, rapid measuring speed, etc.

The present invention relates to a kind of atomic force microscope probe point cleaning method. It is characterized by that said method includes the following steps: coating back surface of pointless one end of lower half-portion of said probe with a small quantity of nail lacquer, fixing it in a cleaning device, placing said cleaning device in which the probe is placed in a dishware in which a cleaning liquor is held, then placing said dishware in an ultrasonic washing channel and low-frequency ultrasonic cleaning for 10 min. Said cleaning device includes two portions of ring-shaped base seat and ring-shaped cover plate, on the base seat several recessed grooves are cut, said base seat and cover plate are fixed together by means of screws.

The invention discloses an intermediate-frequency-modulated low frequency sonophoresis system. The intermediate-frequency-modulated low frequency sonophoresis system comprises a power supply module, a signal generating module, a control module, a digital switch module, a power amplification module, an output module and a man-machine interaction module. The power supply module is electrically connected with the signal generating module and the control module, the signal generating module is sequentially electrically connected with the power amplification module and the output module, and the control module is electrically connected with the digital switch module and the man-machine interaction module respectively. According to the intermediate-frequency-modulated low frequency sonophoresis system, intermediate frequency signals are modulated into low frequency ultrasound driving signals to produce a power source for medicine sonophoresis with modulated low frequency ultrasonic waves as positioning treatment, and accordingly, advantages such as strong penetrating power, low reentry rate and little thermal transition can be obtained; an intermediate-frequency focus is used for taking place of a low-frequency focus, so that the volume of equipment application components is reduced and further requirements of accurate, flexible, simple, convenient and safe use and operation can be achieved and effects of sonophoresis treatment can be better.

The invention provides a low-pressure driven shift shaft Vickers curve type low-frequency ultrasonic three-time atomization spray head. The whole vibration direction of the spray head is the axial vibration direction. An ultrasonic amplitude transformer is a shift shaft Vickers curve type composite amplitude transformer. Four piezoelectric ceramics are sequentially connected from left to right through fastening bolts and divided into upper and lower eight piezoelectric ceramic half wafers, the eight piezoelectric ceramic half wafers achieve composite bending and vibration of the piezoelectric ceramics through axial polarization, and therefore fog drips are finer. According to the working principle of the low-frequency ultrasonic three-time atomization spray head, a nutrient solution enters the ultrasonic atomization spray head from a solution inlet in the shift shaft Vickers curve type amplitude transformer and flows out from a solution outlet, first-time atomization is completed on the right end face of the solution outlet, second-time atomization is completed through the effect of wing power of a fan, and third-time atomization is completed through laser space time on a metal sheet. The defect that the low-frequency ultrasonic atomization cannot easily complete ultra-fine fog drips is overcome, and the low-pressure driven shift shaft Vickers curve type low-frequency ultrasonic three-time atomization spray head can be used in the fields of atomization cultivation, ultrasonic spraying and the like.

The invention discloses a low-frequency bending vibration type secondary ultrasonic atomizer which comprises an atomizing chamber, a piezoelectric vibrator, a fixed plate, a baffle wafer, a circuit device box, a check valve and the like. The piezoelectric vibrator comprises piezoelectric ceramic and a metal wafer, is externally coated with a rubber ring, is fixedly arranged in the fixed plate and is electrically connected with a DC (Direct Current) power supply in the circuit device box; a water inlet pipeline is arranged and fixed on the left side wall of the atomizing chamber; the aperture of the water outlet end of the water inlet pipeline is 1mm; the ultrathin baffle wafer is arranged at the water outlet end of the water inlet pipeline; a bracket with an inclination angle of 30 degrees is arranged and fixed at the back of the baffle wafer and is used for limiting an upward rotating angle of a tin foil paper board wafer not to be greater than 30 degrees. A micro circuit board is arranged and fixed in the circuit device box; moreover, the right end of the atomizing chamber is provided with an external circuit connecting hole, which is convenient to connect with a power supply. The low-frequency bending vibration type secondary ultrasonic atomizer overcomes the defects of low working efficiency, serious heating of a circuit and the atomizer, difficulty in generating superfine fogdrop and the like of an existing low-frequency ultrasonic atomizer and can be applied to atomization cultivation, agricultural humidification and drug atomization treatment.

The invention discloses a data processing method for low-frequency ultrasonic thoracic cavity imaging, which comprises the following steps: modeling through COMSOL, neglecting a spine and a heart in a model, combining two lungs into an ellipse with a long axis length of 0.15 m and a short axis length of 0.1 m, arranging a circle of annular skeletal muscle outside the ellipse of the lungs, uniformly placing 12 ultrasonic transducers around the exterior of the skeletal muscle, the material is set to be PZT-5H; one transducer is used as a sound source Sk which needs to be identified, seven transducers which directly face each other are used as receiving array elements, and signals received by the array elements are subjected to sound source identification processing by using a multi-signal classification (Multiple Signal Characterization,MUSIC) algorithm; a model is established through COMSOL, and a data processing technology applied to the field of low-frequency ultrasonic thoracic cavity imaging is creatively discovered according to a cyclic transmitting-receiving mode of one transmitting and seven receiving. According to the technology, the signal-to-noise ratio of array receiving data can be improved, and the mean square error of the data is reduced.

The invention provides a pneumatic type three-parameter Weibull low-frequency ultrasonic atomizing spray nozzle. The overall vibrating direction of the spray nozzle is the axial direction. A three-parameter Weibull curve type amplitude change rod is adopted as an amplitude change rod of the three-parameter Weibull curve type low-frequency ultrasonic three-time atomizing spray nozzle. The size of metal used in the three-parameter Weibull curve type amplitude change rod is small, less heat is emitted, and the defects that amplitude rods of other shapes are large in metal size and emit much heatare overcome. According to the pneumatic type three-parameter Weibull low-frequency ultrasonic atomizing spray nozzle, by means of the high-pressure airflow effect of an air compressor on a wind inputpipeline, fog drops are subjected to atomizing of the third time on the right end face of a metal sheet. The defect that ultrathin fog drops cannot be generated easily through low-frequency ultrasonic atomizing is overcome, and the spray nozzle can be applied to the fields of atomizing cultivation, ultrasonic spraying and the like.