Preparation and purification method of lotus plumule total alkali perchlorate

Abstract

The invention relates to a method for preparing lotus plumule total alkali perchlorate from lotus plumule total alkali and purifying the lotus plumule total alkali perchlorate. The method comprises the following specific operation steps: taking 1 part of liensinine powder, adding a proper amount of commercially available perchloric acid to completely dissolve the liensinine powder, adding a proper amount of purified water to dilute the liensinine powder until the mass concentration of the perchloric acid is 1-40%, adding a proper amount of water-saturated dichloromethane to extract for 1-3 times, combining the dichloromethane, recovering, concentrating and drying to obtain the liensinine total alkali perchlorate. An existing alkaloid salt forming process usually adopts a method of firstly forming salt and then crystallizing in an organic solvent, but the crystallization time is long and the yield is low. Compared with the prior art, the method for preparing and purifying the lotus plumule total alkali perchlorate, provided by the invention, is simpler and more efficient, and is suitable for industrial mass production.

Description

technical field [0001] The invention belongs to the preparation technology of traditional Chinese medicine alkaloids, in particular to a method for preparing and purifying perchlorate of lotus root total alkaloids (hereinafter referred to as lotus root total alkaloids). Background technique [0002] The lotus seed heart is the dry young leaves and radicles of the mature seeds of the water lily family plant lotus (Nelumbo nucifera Gaertn). It is a variety recorded in the "Chinese Pharmacopoeia" in previous editions. The effect of heat, solid essence and hemostasis. Traditional Chinese medicine is used for the treatment of heat entering the pericardium, disharmony between heart and kidney, insomnia and nocturnal emission, blood heat and vomiting blood. [0003] Lieninin total alkaloids are the main active ingredients in lotus seeds, including liensinine, isoliensinine and methyl-liensinine, etc., which have a wide range of biological activities such as lowering blood pressure...

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Problems solved by technology

[0005] But, above method is all not suitable for the preparation and the purification of Lianxin total alkaloid perchlorate

Because the total alkaloids of Lianxin react with perchloric acid to form a salt, it is very easy to dissolve in the reaction solution and it is difficult to crystallize. Even if it is placed in a refrigerator at 4°C for several days, there is still no crystallization; The acid has a boiling point as high as 203°C and is difficult to recover, and the remaining reactants and by-products are difficult to remove

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