Bionic spinal cord stent for promoting directional extension of spinal cord injury posterior process
A spinal cord injury and spinal cord technology, applied in the field of bionic spinal cord scaffolds, can solve the problems of poor repair effect, limited cell proliferation and growth, limited effectiveness and safety of tissue engineering material selection range, etc., and achieve mechanical strength and mechanical properties. Good, promoting the effect of directed differentiation
Active Publication Date: 2022-04-19
冯世庆
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Problems solved by technology
[0003]The growth of cells cultured on two-dimensional cell scaffolds showed an obvious bottleneck effect, and the inhibition of two-dimensional space and intercellular competition limited the proliferation and growth of cells
Due to the complexity of the anatomical structure and biological function of spinal cord tissue, the selection range of tissue engineering materials is limited by the effectiveness and safety. Currently applicable bionic materials, because they cannot approximate the structure and function of the spinal cord structure, lead to their repair effect. poor
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[0050] The following descriptions are preferred implementations of the embodiments of the present invention. It should be pointed out that those skilled in the art can make some improvements and modifications without departing from the principles of the embodiments of the present invention. These improvements And retouching are also regarded as the scope of protection of the embodiments of the present invention.
[0051] The embodiment of the present application provides a bionic spinal cord support that promotes the directional extension of axons after spinal cord injury, such as Figure 1 to Figure 3 As shown, the bionic spinal cord support includes:
[0052] At least two layers of basal layer 1, the basal layer 1 carries bone marrow mesenchymal stem cells; and
[0053] At least one support layer 2, the support layer is arranged between the at least two base layers, the support layer is used to support the at least two base layers, and the support layer 2 includes a plurali...
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Abstract
The invention relates to the field of medical instruments, and provides a bionic spinal cord stent for promoting directional extension of spinal cord injury posterior process, the bionic spinal cord stent comprises: at least two matrix layers carrying bone marrow mesenchymal stem cells; the substrate layer comprises at least two substrate layers and at least one supporting layer, the supporting layer is arranged between the at least two substrate layers, the supporting layer is used for supporting the at least two substrate layers, the supporting layer comprises a plurality of supporting units which are arranged at intervals, and pores are formed among the plurality of supporting units; the support unit carries Schwann cells, and the pores are used for guiding axons to directionally extend. The bionic spinal cord stent for promoting the directional extension of the posterior process after spinal cord injury, provided by the invention, can simulate the structure and the function of a spinal cord structure, promote mesenchymal stem cells to differentiate towards neurons, and guide the directional extension of the posterior process axis.
Description
technical field [0001] The application relates to the technical field of medical devices, in particular to a bionic spinal cord support for promoting directional extension of axons after spinal cord injury. Background technique [0002] Spinal cord injury is a permanently devastating condition associated with high disability, poor prognosis, and high costs. Functional recovery after SCI mainly focuses on the regeneration of neurons and the growth of axons. However, a single therapeutic strategy, such as cell transplantation, cannot function effectively, long-term, and stably, so that it cannot adapt to the variable microenvironment. Therefore, it is essential to establish a combined tissue engineering strategy for cell transplantation. [0003] The growth of cells cultured on two-dimensional cell scaffolds showed an obvious bottleneck effect, and the inhibition of two-dimensional space and intercellular competition limited the proliferation and growth of cells. Due to the...
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Login to View More IPC IPC(8): A61F2/02A61L27/22A61L27/38A61L27/50
CPCA61F2/02A61L27/3834A61L27/383A61L27/3878A61L27/222A61L27/50A61L2430/32
Inventor 冯世庆王健豪刘洋班德翔李倩宁广智喻鹏
Owner 冯世庆