Application of phenethyl caffeate in preparation of anti-cervical cancer drugs

Abstract

The invention provides a caffeic acid phenethyl ester as a medicine for resisting cervical cancer. The invention provides application of caffeic acid phenethyl ester as an E6AP / p53 compound inhibitor and an inhibitor for ubiquitination degradation of p53. Experimental research shows that in a cell experiment, CAPE can inhibit the interaction between E6AP and p53 in an HR-HPV positive cervical cancer cell line, reduce the ubiquitination modification level of p53, prolong the half-life period of p53 and increase the level of p53.

Description

technical field [0001] The invention discloses the application of phenethyl caffeate in the preparation of anti-cervical cancer drugs, belonging to the technical field of medicine. Background technique [0002] E6-associated protein (E6-associated protein, E6AP) is a ubiquitin-activating enzyme (E3), which is highly expressed in HR-HPV positive cervical cancer. E6AP can combine with E6 to form an E6 / E6AP complex, and the two can combine with the tumor suppressor protein p53 to form an E6AP / E6 / p53 complex, which mediates the ubiquitination and degradation of p53, reduces the level of p53, and inhibits its effect on cells. Growth regulation, causing cell proliferation and malignant transformation. [0003] p53 can initiate DNA damage repair, cause cell cycle arrest, and induce cell apoptosis. The occurrence of tumors is mostly related to the mutation or deletion of p53. In most cervical cancer cell lines, p53 is wild type and has biological functions, but its tumor suppresso...

AI Technical Summary

Problems solved by technology

Surgery, radiotherapy and chemotherapy are currently the main clinical treatment methods for cervical cancer, but both have limitations

70% of patients are diagnosed at an advanced stage and are not suitable for surgical treatment. Cervical squamous cell carcinoma is relatively sensitive to radiotherapy, but radiotherapy can easily cause damage to normal tissues around the tumor. Cervical adenocarcinoma is relatively poorly sensitive to radiotherapy, and chemotherapy is often used. However, Drug resistance is prone to occur, and chemotherapy drugs have poor targeting and strong side effects

There are no literature reports on the application of inhibiting the interaction between E6AP and p53, reducing the ubiquitination modification of p53, increasing the protein level of p53 and exerting anti-cervical cancer effects.

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