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Self-driven micro-fluidic chip

A self-driving micro-chip technology, applied in laboratory appliances, laboratory containers, chemical instruments and methods, etc., can solve the problems of lack of effective structural design, reduce the possibility of air bubbles, enhance efficiency, and simplify design Effect

Active Publication Date: 2022-04-29
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this invention lacks an effective structural design from the first buffer part to the channel part, so as to ensure that the sample is fully mixed, and various substances are fully combined to ensure less air bubbles and smooth liquid surface flow

Method used

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  • Self-driven micro-fluidic chip
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  • Self-driven micro-fluidic chip

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Embodiment approach

[0023] figure 1 It is a schematic diagram of the overall structure of the flow channel of the microfluidic chip of the present invention, which is divided into four parts as a whole, namely, 110 sample injection area, 120 antibody release area, 130 channel detection area, and 140 front end of waste liquid area. The part displayed as a whole is the flow channel of the microfluidic chip, that is, the sample enters the microfluidic chip from 110, passes through the antibody release area at 120, the channel detection area at 130, and the front end of the waste liquid area at 140. In the figure: 110 is a sample injection area, which is used to inject target analyte, and many micro-columns are distributed on it, which is used to expand the specific surface area and strengthen the mixing of the sample and the pre-set at 110. Part 120 is the antibody release area, wherein 121 is the front end of the antibody release area, which acts as a guide. The initial height of the front end of t...

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Abstract

The invention provides a self-driven micro-fluidic chip for immunofluorescence detection, which mainly comprises a sample injection area for injecting a target analyte; the antibody release area is used for releasing a fluorescent substance-antibody compound and combining with a target analyte; the channel detection area is used for capturing a fluorescent substance-antibody-antigen compound formed after the sample passes through the antibody release area so as to carry out fluorescence detection; the device is characterized in that a structure for bending the whole channel up and down exists in the front section of a channel detection area part, that is, the channel fluctuates up and down from the outside, so that when liquid in the channel passes through the bent structure, horizontal displacement and up-and-down displacement are generated, a series of vortex flow fields are generated, reactants are fully and uniformly mixed, and the detection efficiency is improved. And the fluid passing time can be adjusted by setting the number and length of the bent structures.

Description

Background technique [0001] With the development of immune technology, point of care (POCT), as a new field in laboratory medicine, has attracted more and more attention. It is a new type of method for sampling and analyzing immediately at the patient's site, eliminating the complicated processing procedures of specimens in the laboratory, and quickly obtaining test results, which is of great significance to emergency rescue and other aspects. It has a wide range of applications in blood sugar detection, cardiovascular disease detection, infectious diseases, drug abuse, pregnancy monitoring, etc. The technical principles of POCT mainly include: colloidal gold, dry immunofluorescence, microfluidic immunofluorescence, etc. At present, colloidal gold and dry immunofluorescence have become mainstream technologies in the market, while microfluidics will be the mainstream direction of future development. [0002] Both colloidal gold and dry immunofluorescence detection techniques ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027Y02A50/30
Inventor 叶青孔祥天谢俊芳田建国
Owner NANKAI UNIV
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