Synthetic method of aryl phosphate

Abstract

The invention provides a synthesis method of aryl phosphate ester, which comprises the following steps: taking aryl azo sulfone as a raw material, and reacting with triphenyl phosphite under electrochemical conditions to obtain a corresponding aryl phosphate ester compound. The method has the advantages of cheap and easily available raw materials, simple operation, mild reaction conditions, greenness, high yield and greatly shortened reaction time. The method provided by the invention utilizes electrons as reactants to realize selective oxidation or reduction conversion, avoids the use of stoichiometric oxidants, metal catalysts and alkalis, and meets the requirements of green chemical development. The reaction has high selectivity, so that derivatization reactions such as protection / deprotection are avoided, and the method is suitable for industrial production.

Description

technical field [0001] The invention relates to a novel synthesis method of aryl phosphate compounds, belonging to the technical field of electrochemical organic synthesis. Background technique [0002] As an important class of organophosphorus compounds, aryl phosphonates are widely used in the fields of medicinal chemistry, material science and organic synthesis, which makes the synthesis of such compounds of great significance. Phosphorous moieties act as ligands to coordinate with transition metals or bind to biological receptors, thereby modulating physiological processes or material functions. Therefore, the development of efficient and mild phosphonylation reactions has been the subject of extensive synthetic research. The field has long been dominated by transition metal catalysis, but reports on the use of visible-light photoredox catalysis and electrocatalysis as a mild and efficient strategy to access aryl phosphonates have attracted increasing attention in recen...

AI Technical Summary

Problems solved by technology

No photocatalyst is used in the reaction system and the reaction conditions are mild, but there is a problem that the reaction time is too long

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