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Carbocisteine oral solution

An oral solution, the technology of carbocisteine, which is applied in the field of medicine, can solve the problems not involved in the dissolution of carbocisteine, and achieve the effects of preventing the precipitation of insoluble raw materials, low price and increasing solubility

Pending Publication Date: 2022-06-14
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, neither address its role in increasing the dissolution of carbocisteine

Method used

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  • Carbocisteine oral solution
  • Carbocisteine oral solution
  • Carbocisteine oral solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, carbocisteine ​​oral solution

[0020]

[0021] Preparation method: take sodium hydroxide and dissolve it in partially purified water to prepare a sodium hydroxide solution, take the prescribed amount of carbocisteine, dissolve it in partially purified water, slowly add the above sodium hydroxide solution dropwise, and stir until the carbocisteine Tan is completely dissolved, get the recipe quantity glycerol and add the sodium methyl parahydroxybenzoate of the recipe quantity, after fully stirring and dissolving, add the recipe quantity: hydroxyethyl cellulose, sodium saccharin, fully stir to make it dissolve completely, measure the solution pH, add water Dilute to volume, filter, sterilize, and get it.

Embodiment 2

[0022] Embodiment 2, carbocisteine ​​oral solution

[0023]

[0024] Refer to Example 1 for the preparation method.

Embodiment 3

[0025] Embodiment 3, carbocisteine ​​oral solution

[0026]

[0027] Refer to Example 1 for the preparation method.

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PUM

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a carbocisteine oral solution and preparation thereof, the carbocisteine oral solution comprises 2-3% of carbocisteine, 5-10% of pregelatinized starch, 5-20% of saccharin sodium salt, 1-3% of sodium hydroxide and 0.2-0.3% of preservative, and the preservative is sodium methyl p-hydroxybenzoate. The carbocisteine oral solution provided by the invention has better long-term stability and good taste, the pregelatinized starch increases the taste and the solubility of the carbocisteine oral solution to prevent insoluble raw materials from being separated out, the oral solution is still stable and clear after being stored for 36 months at room temperature, the content of effective components is reduced by only 0.1-0.3%, and the oral solution is suitable for oral administration. Compared with the prior art, remarkable progress is achieved.

Description

Technical field [0001] The invention belongs to the field of medical technology, and specifically relates to carbocisteine ​​oral solution. Background technique [0002] Carbocysteine ​​is a multi-element compound containing two carboxyl groups and one amino group. It is often used as a sputum thinner in clinical practice. After oral administration, the secretion of glands in the organs and bronchus increases, and the sputum changes to alkenes, making the sputum easier to cough up. , it has a rapid onset of action when taken orally, and obvious effects can be seen 4 hours after taking it. It is usually made into solid preparations, such as tablets. [0003] Compared with solid preparations, liquid preparations can improve taste, enhance absorption, and improve bioavailability to a limited extent. However, due to the low solubility of carbocisteine ​​in water (only about 0.16%), although the solubility of carbocisteine ​​after salt formation is improved, because its aqueous ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/198A61K47/36A61K47/38A61K47/14A61P11/12
CPCA61K9/08A61K9/0053A61K31/198A61K47/36A61K47/38A61K47/14A61P11/12
Inventor 不公告发明人
Owner BEIJING VENTUREPHARM BIOTECH
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