Carbocisteine oral solution

An oral solution, the technology of carbocisteine, which is applied in the field of medicine, can solve the problems not involved in the dissolution of carbocisteine, and achieve the effects of preventing the precipitation of insoluble raw materials, low price and increasing solubility

Pending Publication Date: 2022-06-14
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, neither address its role in inc

Method used

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  • Carbocisteine oral solution
  • Carbocisteine oral solution
  • Carbocisteine oral solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, carbocisteine ​​oral solution

[0020]

[0021] Preparation method: take sodium hydroxide and dissolve it in partially purified water to prepare a sodium hydroxide solution, take the prescribed amount of carbocisteine, dissolve it in partially purified water, slowly add the above sodium hydroxide solution dropwise, and stir until the carbocisteine Tan is completely dissolved, get the recipe quantity glycerol and add the sodium methyl parahydroxybenzoate of the recipe quantity, after fully stirring and dissolving, add the recipe quantity: hydroxyethyl cellulose, sodium saccharin, fully stir to make it dissolve completely, measure the solution pH, add water Dilute to volume, filter, sterilize, and get it.

Embodiment 2

[0022] Embodiment 2, carbocisteine ​​oral solution

[0023]

[0024] Refer to Example 1 for the preparation method.

Embodiment 3

[0025] Embodiment 3, carbocisteine ​​oral solution

[0026]

[0027] Refer to Example 1 for the preparation method.

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PUM

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a carbocisteine oral solution and preparation thereof, the carbocisteine oral solution comprises 2-3% of carbocisteine, 5-10% of pregelatinized starch, 5-20% of saccharin sodium salt, 1-3% of sodium hydroxide and 0.2-0.3% of preservative, and the preservative is sodium methyl p-hydroxybenzoate. The carbocisteine oral solution provided by the invention has better long-term stability and good taste, the pregelatinized starch increases the taste and the solubility of the carbocisteine oral solution to prevent insoluble raw materials from being separated out, the oral solution is still stable and clear after being stored for 36 months at room temperature, the content of effective components is reduced by only 0.1-0.3%, and the oral solution is suitable for oral administration. Compared with the prior art, remarkable progress is achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to a carbocisteine ​​oral solution. Background technique [0002] Carbocisteine ​​is a multi-element compound containing two carboxyl groups and one amino group. It is often used as a sputum diluent in clinical practice. After oral administration, the secretion of organs and bronchial glands increases, and the sputum becomes alkene, so that the sputum is easy to cough up. , Oral onset is fast, and obvious curative effect can be seen 4 hours after taking it, and it is usually made into solid preparations, such as tablets. [0003] Compared with solid preparations, liquid preparations can improve the taste to a limited extent, enhance absorption, and improve bioavailability. However, due to the low solubility of carbocisteine ​​in water (only about 0.16%), although the solubility of carbocisteine ​​after salification is improved, because its aqueous solution is acidic, it...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/198A61K47/36A61K47/38A61K47/14A61P11/12
CPCA61K9/08A61K9/0053A61K31/198A61K47/36A61K47/38A61K47/14A61P11/12
Inventor 不公告发明人
Owner BEIJING VENTUREPHARM BIOTECH
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