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Radioactive resin microsphere injection as well as preparation method and application thereof

A resin microsphere, radioactive technology, applied in the field of medicine, can solve the problem of inability to determine the dose of radioactive administration, and achieve the effect of solving difficult direct injection and reducing toxic and side effects

Pending Publication Date: 2022-06-24
CHENGDU NEW RADIOMEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently reported radioactive microsphere products, such as: the above-mentioned yttrium[ 90 Y] resin microspheres SIR-Spheres® and holmium[ 166 Ho] Resin microspheres (QuriemSphere®) are all heterogeneous, and the radioactive dose cannot be accurately determined by the volume of administration

Method used

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  • Radioactive resin microsphere injection as well as preparation method and application thereof
  • Radioactive resin microsphere injection as well as preparation method and application thereof
  • Radioactive resin microsphere injection as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A preparation of yttrium [ 90 Y] the method for resin microsphere injection, this method comprises the following steps:

[0049] Dissolve 20 mg of sodium alginate in 10 ml of sterile water for injection, pass through a 0.22 μm sterile filter membrane, add 10 ml of 0.45 g / L sterile calcium chloride solution, and mix to obtain a viscosity of 16.6 mPa·S (about 20 ℃) ​​calcium alginate hydrogel, as A1 agent; the yttrium [ 90 50mg of Y] resin microspheres were dispersed in 1ml of sterile water for injection, packaged, and sterilized by moist heat at 121°C for 15min for later use. The radioactive resin microspheres did not start to settle within 2 hours of the injection.

Embodiment 2

[0051] A preparation of yttrium [ 90 Y] the method for resin microsphere injection, this method comprises the following steps:

[0052] Dissolve 20 mg of sodium alginate in 10 ml of sterile water for injection, pass through a 0.22 μm sterilizing filter membrane, and encapsulate it for later use as agent A2. The yttrium [ 90 Y] 100 mg of resin microspheres are dispersed in 1 ml of sterile water for injection containing 5 mg of calcium chloride, packaged, sterilized by moist heat at 121°C for 15 minutes, and used as agent B2. Add the A2 agent obtained above to the B2 agent, and mix well. The radioactive resin microspheres did not start to settle within 2 hours of the injection.

Embodiment 3

[0054] A preparation of holmium [ 166 Ho] the method for resin microsphere injection, the method comprises the following steps:

[0055] Dissolve 20 mg of sodium alginate in 10 ml of sterile water for injection, pass through a 0.22 μm sterilizing filter membrane, and encapsulate it for later use as agent A2. The holmium [ 166 300 mg of Ho] resin microspheres were dispersed in 1 ml of sterile water for injection containing 5 mg of calcium chloride, packaged, sterilized by moist heat at 121°C for 15 minutes, and used as agent B2. Add the A2 agent obtained above to the B2 agent, and mix well. The radioactive resin microspheres did not start to settle within 2 hours of the injection.

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Abstract

The invention belongs to the technical field of medicine, and discloses a radioactive resin microsphere injection and a preparation method and application thereof, and every 1 ml of the radioactive resin microsphere injection comprises 0.1-300 mg of radioactive resin microspheres and 1-0.75 ml of hydrogel. The injection is used for preparing a medicine for treating tumors, can be directly injected into the tumors in an interventional manner, and can directly determine the radioactive dose of the radioactive resin microspheres through the administration volume, so that hydrogel in the tumors can form gel with calcium ions in the tumors, and the effect of treating the tumors is achieved. Therefore, the radioactive resin microspheres are uniformly dispersed and limited in the tumor, high-dose local radiotherapy is provided through the radioactive resin microspheres to achieve treatment of the solid tumor, and the radioactive resin microspheres have wide application prospects in solid tumor treatment.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a radioactive resin microsphere injection and a preparation method and application thereof. Background technique [0002] At present, the radioactive resin microsphere products used clinically mainly include yttrium [ 90 Y] resin microspheres SIR-Spheres® (Sirtex Medical Limited) and holmium [ 166 Ho] resin microspheres QuriemSphere® (Terumo Medical), these two microsphere products are radioactive resin microsphere products dispersed in sterile water for injection or 0.9% sodium chloride injection solution. The rapid and easy occurrence of needle blockage makes it impossible for this type of product to be administered directly through a syringe. In order to achieve the convenience of administration and the purpose of radiation shielding, its administration requires the aid of figure 1 As shown in the perfusion drug delivery device, this drug delivery method requires flushing ...

Claims

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Application Information

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IPC IPC(8): A61K51/06A61K51/12
CPCA61K51/1251A61K51/1213A61K51/06A61K51/12
Inventor 赵小生张钧路静白冰马文亮张驰翔刘强强谭文静吕果罗显进赵世强葛强蔡继鸣
Owner CHENGDU NEW RADIOMEDICINE TECH CO LTD
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