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Compounds for treatment of sepsis

A compound and technology for sepsis, which is applied in the field of compounds for sepsis treatment, achieves the effect of less side effects and improved survival rate

Pending Publication Date: 2022-07-01
HANGZHOU BANGSHUN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But hormone therapy can lead to more serious sequelae, such as obesity, osteoporosis, etc.

Method used

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  • Compounds for treatment of sepsis
  • Compounds for treatment of sepsis
  • Compounds for treatment of sepsis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Reagents and animal information

[0032] Reagents: Compound Ia, Dexamethasone, LPS;

[0033] Vehicle: 0.5% methylcellulose (MC), phosphate buffered saline (PBS);

[0034] Animals: C57BL / 6 mice, male, 6-8 weeks old.

[0035] 2. Preparation of sample solution

[0036] LPS solution: Dissolve an appropriate amount of LPS powder in sterile PBS to prepare a 2 mg / ml solution for intraperitoneal injection modeling.

[0037] Compound Ia solution: Weigh compound Ia, add it into 0.5% MC solution, turn on the magnetic stirrer and stir for 30-60min, and then ultrasonicate for 15min, and a white homogeneous suspension is obtained. Then, gradient dilution was performed with 0.5% MC, vortexed evenly, and a white homogeneous suspension was obtained to obtain a low-concentration compound Ia solution.

[0038] Dexamethasone solution: Prepare by dissolving dexamethasone in 0.5% MC solution.

[0039] 3. Experimental process

[0040] Based on animal body weight, on day 0, 43 animals...

Embodiment 2

[0055] tablet preparation

[0056] ①Mix

[0057] 1. Pretreatment stage: Pass the raw and auxiliary materials through a 40-mesh sieve respectively according to the prescription composition in Table 3, and take the prescription amount for later use.

[0058] 2. One mixing: Ia, lactose and 50% silicon dioxide were mixed with a hopper mixer for 10 minutes at 20 rpm.

[0059] 3. Two-mix: Add pregelatinized starch, cross-linked PVP, and remaining silicon dioxide to the premix, mix for 10min, and rotate at 20rpm.

[0060] 4. Mixing: Add the lubricant magnesium stearate to the material in the hopper mixer, start mixing for 5 minutes, and rotate at 20 rpm.

[0061] ②Tablet:

[0062] Taking into account the results of theoretical tablet weight and particle content, a shallow arc circular punch with a diameter of 8 mm was used for tablet compression, and the hardness ranged from 4 to 9 kg.

[0063] ③Coating:

[0064] 10% Opadry coating solution was prepared and coated, and the final...

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Abstract

The invention provides an application of a compound shown as a formula I or a salt thereof in preparation of a medicine for preventing or treating sepsis. In particular, when X in the formula I is N and R is ethyl, the compound Ia shows better curative effect and safety in a mouse sepsis model, the drug effect of the compound Ia is equivalent to that of hormone, and meanwhile, the compound Ia has smaller side effects.

Description

[0001] This application claims the priority of the prior application with the patent application number 202011579105.9 and the invention titled "compounds for sepsis treatment" filed with the State Intellectual Property Office of China on December 28, 2020. The entirety of this application is incorporated herein by reference. technical field [0002] The present invention relates to a new use of a medicine, in particular to the use of compound formula I, a salt or a composition thereof in the preparation of a medicine for preventing or treating sepsis. Background technique [0003] Sepsis is a systemic inflammatory response syndrome (SIRS) caused by infection, with clinically confirmed bacterial presence or highly suspected infection foci. Although sepsis is caused by infection, once it occurs, its occurrence and development follow its own pathological process and laws, so in essence, sepsis is the body's response to infectious factors. [0004] This systemic excessive infl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P29/00A61P31/04A61P31/12
CPCA61K31/519A61P29/00A61P31/04A61P31/12
Inventor 郑鹛诸葛定娟赵梦佳陈南雨殷建明吕裕斌
Owner HANGZHOU BANGSHUN PHARM CO LTD