Application of glucosamine and derivatives thereof as antiviral drugs

Abstract

The invention relates to application of glucosamine and derivatives thereof as antiviral drugs. The invention provides an application of a glucosamine compound as shown in a general formula I and pharmaceutically acceptable salt or solvate thereof in preparation of antiviral drugs. The compound has a good antiviral effect, especially has very obvious broad spectrum of the antiviral effect, and can be used for preparing antiviral drugs.

Description

[0001] This application is a divisional application of the Chinese patent application "Application of Glucosamine and Its Derivatives as Antiviral Drugs" (application number: 201910192721X, application date: March 13, 2019). technical field [0002] The invention belongs to the field of medicine, and in particular relates to an application of glucosamine and its derivatives in the preparation of antiviral drugs and a preparation method thereof. Background technique [0003] N-acetyl-D-glucosamine is the smallest unit of chitin, and it is also the basic unit of many important polysaccharides in biological cells. It is an amino monosaccharide formed by the substitution of the OH group at the 2-position in the glucose molecule by an acetylamino group. Chemically, it can be easily synthesized by acetylating the amino group at the 2-position in the glucosamine molecule. Natural N-acetyl-D-glucosamine can be hydrolyzed by biotechnology on the shells of crustaceans (such as crabs a...

AI Technical Summary

Problems solved by technology

[0007] Although N-acetyl-glucosamine has a variety of physiological effects, its application in the antiviral field has not been reported. The inventors of the present invention found that N-acetyl-glucosamine and its derivatives It has obvious inhibitory effect on a variety of viruses, and the safety of N-acetylglucosamine has been verified in various aspects, so its development as an antiviral drug has broad prospects

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