Individual space transcranial magnetic stimulation accurate positioning navigation method based on magnetic resonance imaging

Abstract

The invention belongs to the field of biomedical image mode recognition, and provides a magnetic resonance imaging-based individual space transcranial magnetic stimulation accurate positioning and navigation method, which comprises the following steps of: 1, acquiring resting state functional magnetic resonance imaging and high-resolution T1 weighted structure imaging of a patient; step 2, matching the structural image with the functional image, and finding a region of a target nucleus; step 3, performing whole-brain function connection calculation by taking the target nucleus region as a seed point, and searching for a region construction target point functionally connected with the target nucleus in the cortex region; step 4, generating an individualized template with a target mark; and 5, importing the individual template with the target spot mark into the precise navigation TMS instrument. According to the method, the individualized target spot is beneficial for the TMS to carry out accurate intervention according to the characteristics of an individual, and clear guidance is provided for clinical use of intervention measures for specified mental diseases.

Description

technical field [0001] The invention belongs to the field of biomedical image pattern recognition, in particular to a method for precise positioning and navigation of individual space transcranial magnetic stimulation based on magnetic resonance imaging. Background technique [0002] The prior art discloses that functional magnetic resonance imaging (fMRI) is a non-invasive neuroimaging method that utilizes the different paramagnetic properties of oxyhemoglobin and deoxyhemoglobin. A large number of studies have found that the co-variation process between different regions of the brain under resting state, that is, the strength and change of resting-state functional connectivity (rsFC) is closely related to demographic variables, mood, memory, cognitive ability and disease characteristics. [0003] Transcranial Magnetic Stimulation (TMS) is a non-destructive neurostimulation technology that uses a pulsed magnetic field to act on the central nervous system (mainly the brain) ...

AI Technical Summary

Problems solved by technology

However, due to the invasiveness of DBS, this method cannot be widely used in a wide range of mental diseases

[0004] Although there are relatively fixed target areas in the existing treatment measures, for example, in the treatment of autism, the left and right dorsolateral prefrontal cortex is usually used as the intervention target, but due to individual differences and heterogeneity of diseases, The effect of TMS is often unsatisfactory, and there is a lack of more precise individualized targets in TMS-related treatments

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