Semi-parametric model-based isolated heart perfusion blood pressure self-adaptive control method

Abstract

The invention discloses an isolated heart perfusion blood pressure self-adaptive control method based on a semi-parametric model, and belongs to the technical field of in-vitro organ protection intelligent systems. The problems that according to an existing isolated heart perfusion technology, the heart is damaged, blood pressure adjustment is difficult to rapidly stabilize, and the heart is damaged when a current controller adjusts gain due to changing heart perfusion conditions are solved. According to the method, an isolated heart is modeled in a mode of combining a parameter model and a non-parameter model, meanwhile, internal parameters of the model are adaptively changed according to changes of various parameters of the isolated heart, and a reference control track is generated on an isolated heart reference model through a virtual controller; meanwhile, the control gain is updated by using the target average aortic pressure, the actual average aortic pressure, the isolated heart semi-parameter model and the virtual controller, and the flow rate of the perfusion blood is controlled by controlling the centrifugal pump through the control gain device. The method is mainly used for isolated heart perfusion blood pressure self-adaptive control.

Description

technical field [0001] The invention relates to a self-adaptive control method for isolated heart perfusion blood pressure, which belongs to the technical field of an in vitro organ protection intelligent system. Background technique [0002] Heart transplantation is the "golden method to solve end-stage heart failure", and the preservation of donor hearts in vitro is very important for heart transplantation. The heart used for transplantation must maintain its intact anatomical structure and activity during the process of transplantation from the donor to the recipient. However, the isolated heart loses its supply of oxygen and nutrients once it is removed from the donor and accelerates death. The traditional method of cryopreservation of donor hearts can delay the death of the heart, but the storage time is only 4 to 6 hours. Beyond this time range, the mortality rate after transplantation is very high. The isolated heart perfusion technique is a new generation of donor ...

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Problems solved by technology

[0004] The present invention is to solve the problem that in the existing isolated heart perfusion technology, the heart is damaged due to the change of various parameters of the isolated heart model, and the blood pressure regulation is difficult to be rapid Stable and changing heart perfusion conditions cause current controllers to damage the heart when adjusting gains

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