Blood brain barrier permeability detection method, device and system

Abstract

The invention provides a blood brain barrier permeability detection method, device and system, and the method comprises the steps: determining a first target volume based on the attribute information of a to-be-detected drug obtained in advance, and transmitting a first instruction to an optical fiber measurement device based on the first target volume, the optical fiber measuring device determines a first light response value according to the first instruction; generating a target standard curve based on the first light response value, and sending a second instruction to the optical fiber measuring device according to the target standard curve, so that the optical fiber measuring device determines a second light response value according to the second instruction; generating a target concentration curve based on the second light response value; and based on the target concentration curve, obtaining the permeability of the to-be-detected drug in the target time period. According to the blood-brain barrier permeability detection method, device and system provided by the invention, the concentration change of drugs in the supply chamber and the receiving chamber can be monitored in real time, and meanwhile, simplicity and convenience in operation and high-throughput screening are considered.

Description

technical field [0001] The invention relates to the technical field of drug screening in the nervous system, in particular to a blood-brain barrier permeability detection method, device and system. Background technique [0002] The blood-brain barrier refers to the barrier between blood plasma and brain cells formed by the wall of brain capillaries and glial cells and the barrier between plasma and cerebrospinal fluid formed by the choroid plexus, which can prevent certain substances (mostly harmful ) into the brain tissue from the blood, which has important biological significance for maintaining the normal physiological state of the central nervous system. But it also prevents about 95% of the drug from entering the brain from the blood, which is not conducive to the treatment of brain diseases. Therefore, the detection of drug blood-brain barrier permeability is of great significance for the development of nervous system drugs and the treatment of brain diseases. [000...

AI Technical Summary

Problems solved by technology

[0005] The invention provides a blood-brain barrier permeability detection method, device and system, which are used to solve the defect that high-throughput and real-time detection cannot be taken into account at the same time in the prior art, and realize the aided measurement by optical fiber equipment, which can monitor the blood in real time. Concentration changes in brain barrier simulated environments

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