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Application of PCSK9 in tumor immunotherapy and enhancement of immune effect of immune cells

A technology of immune cells and cellular immunity, applied in blood/immune system cells, medical preparations containing active ingredients, anti-tumor drugs, etc., can solve the problem of affecting the anti-tumor effect of immune cells, etc. Survival period, effect of promoting antitumor effect

Pending Publication Date: 2022-07-19
SOUTHERN MEDICAL UNIVERSITY
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  • Description
  • Claims
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Problems solved by technology

This type of tumor microenvironment will inhibit CD8 + The anti-tumor activity of T cells and immune cells, and in addition to the inhibition of the effector function of immune cells caused by tumor microenvironmental characteristics such as the lack of nutrients such as glucose and hypoxia, some studies have also found that the tumor microenvironment can affect the immune system through metabolic regulation. cellular antitumor effect

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  • Application of PCSK9 in tumor immunotherapy and enhancement of immune effect of immune cells
  • Application of PCSK9 in tumor immunotherapy and enhancement of immune effect of immune cells
  • Application of PCSK9 in tumor immunotherapy and enhancement of immune effect of immune cells

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Embodiment Construction

[0039] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the application. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0040] It should be noted that the terminology used herein is for the purpose of describing specific embodiments only, and is not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural as well, furthermore, it is to be understood that when the terms "comprising" and / or "including" are used in this specification, it indicates that There are features, steps, operations, devices, components and / or combinations thereof.

[0041] The present invention will now be further described with reference to specific examples. T...

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Abstract

The invention relates to application of PCSK9 in tumor immunotherapy and enhancement of immune effect of immune cells. The invention discloses the regulation and control effects of cholesterol metabolism related genes and proteins on the immune effect and antitumor activity of immune cells, and the regulation and control process does not completely depend on the uptake of cholesterol, thereby providing new strategies and targets for tumor immunotherapy or enhancement of the immune effect of the immune cells, and overcoming the technical prejudice in the prior art. Specifically, it is found that PCSK9 depends on LDLR and directly affects TCR cyclic utilization and signal transduction pathways of immune cells, so that corresponding CTLs have different effect function expressions. The PCSK9 can be used as a tumor cell and / or immune cell inhibition target spot to be adjusted so as to improve the killing effect of CTL, is applied to tumor immunotherapy, and is beneficial to improving the tumor immunotherapy effect and prolonging the lifetime of a patient. And PCSK9 inhibition can be combined with an immune checkpoint blocking agent to further improve the immunotherapy effect.

Description

technical field [0001] The invention relates to the field of immunotherapy, and more particularly, to the application of PCSK9 in tumor immunotherapy and enhancement of immune cell immune effect. Background technique [0002] Malignant tumor is a major disease that seriously endangers human life and health. At present, the treatment methods for malignant tumor mainly include surgery, radiotherapy, chemotherapy and immunotherapy. Among them, tumor immunotherapy aims to inhibit and kill tumor cells by mobilizing the body's immune system to provide anti-tumor efficacy, and is an important means of current tumor therapy. In particular, immunotherapy with T cells as the core has achieved certain curative effects in various types of tumors. [0003] T cells are an important component of the adaptive immune system, which can recognize specific antigens and mediate cellular immune responses, and play an important role in resisting foreign pathogen infection, tumor immunity and auto...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K45/06A61K39/395A61P35/00A61P37/04C12N5/0783
CPCA61K45/00A61K45/06A61K39/3955A61P35/00A61P37/04C12N5/0636C12N9/6454C12Y304/21061A61K2300/00
Inventor 杨魏袁娟娟蔡婷郑晓君
Owner SOUTHERN MEDICAL UNIVERSITY
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