Treatment of spasticity, convulsions by isovaleric acid derivatives CNS
A technology of isovaleric acid and isovaleramide, applied in the direction of anhydride/acid/halide active ingredients, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc., can solve muscle relaxation and application limitations And other issues
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example 1
[0086] Use of valerian preparations to alleviate and multiple
[0087] sclerosis-associated ankylosis
[0088] A human female subject, 42 years of age, with one or more symptoms of multiple sclerosis, was experiencing considerable stress and had difficulty falling asleep at night and delayed sleep onset, often suffering from catatonic dreaming and often Disturbance of awakening. The subject also experienced frequent nocturnal painful lower extremity extensor cramps, which also frequently aroused her from sleep. The next day, these painful extensor spasms cause deep muscle pain (bruising) with muscle / joint stiffness.
[0089] The subjects decided to use a preparation of valerian root known for its sleep aiding properties. This valerian product, "Baldriparan Stark N," is a tablet made in Germany that contains valerian root, hop and melissa extracts. Each tablet of this coated compressed tablet contains 95 mg of dried 70% (v / v) ethanol extract of...
example 2
[0091] Spinal Cord Relief with Valerian Preparations
[0092] Trauma-Related Tonic Symptoms
[0093] A human male subject, 38 years old, had tonic symptoms (hyperreflexia, tendon reflexes, and extensor spasms.) developed with early spinal cord trauma. All of these symptoms interrupt the sleep of the patient and reduce the quality of his sleep. When taking the same valerian preparation produced in Germany as in Example 1, the subjects noticed a significant improvement in sleep quality in addition to a significant reduction in nocturnal extensor spasms. The subject continued to take the preparation as necessary (prn) to relieve the above symptoms.
example 3
[0095] Isovaleramide antitonic test
[0096] (1) Evaluation of ankylosis in rats with chronic spinal cord transection
[0097] In these studies, male albino rats of Holtzman origin (Harlan Sprague-Dawley Laboratories) weighing between 270-530 grams were used as subjects. The animals were housed individually and given continuous access to food and water throughout the experimental period. All experimental procedures were reviewed and approved by the Animal Care and Use Committee. Anesthetize the animal with a mixture of isoflurane and oxygen at a flow rate of 4 L / min, then place the rat in a stereotaxy frame and maintain anesthesia, make a contractile incision around the spinal column and between T6-T9 Laminectomy was performed to remove a piece of spinal cord tissue with a size of about 1-2mm by suction, and filled with gel foam to reduce bleeding, and then the incision was sutured layer by layer.
[0098] After transection is complete, to maintain the rat'...
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