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Method to enhance healing of sternum after sternotomy

A sternum and thoracic technology, applied in the field of promoting sternum healing, can solve problems such as slow sternum healing and poor healing

Inactive Publication Date: 2004-12-22
KAKEN PHARMA CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In an attempt to overcome the difficulty of slow or poor sternal healing after sternotomy, the inventors have developed several methods of promoting sternal healing as described below

Method used

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  • Method to enhance healing of sternum after sternotomy
  • Method to enhance healing of sternum after sternotomy
  • Method to enhance healing of sternum after sternotomy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The effect of the present invention in promoting sternal healing was evaluated by topical application of bFGF after sternotomy and removal of BITA in rats.

[0053] Using Ca(OH) by alkaline method 2 Gelatin having an isoelectric point of 4.9 was isolated from bovine bone collagen (Nitta Gelatin Co., Osaka, Japan). The gelatin had a weight average molecular weight of 99,000 when determined by gel filtration chromatography against polyethylene glycol standards. Human recombinant bFGF with an isoelectric point of 9.6 was provided by Kaken Pharmaceutical Co., Tokyo, Japan.

[0054] (i) Preparation of gelatin hydrogel sheets mixed with bFGF

[0055] Tablets with different degrees of crosslinking were prepared by chemically crosslinking a 10 wt % aqueous solution of gelatin with different amounts of glutaraldehyde at 25°C. Briefly, 4.5 ml of an aqueous gelatin solution containing glutaraldehyde was cast into a Teflon mold (5×5 cm 2, 1.8mm deep). After the cross-linking r...

Embodiment 2

[0079] The effect of the present invention on promoting sternal healing was evaluated in beagle dogs by topical application of bFGF following sternotomy and removal of BITA.

[0080] (i) Preparation of gelatin hydrogel sheets mixed with bFGF

[0081] In the same manner as in (i) of Example 1, alkali-treated gelatin having an isoelectric point of 4.9 was chemically cross-linked with glutaraldehyde at 25°C to prepare a sterile sheet. These were lyophilized and subsequently impregnated with an aqueous solution containing 100 μg of bFGF to obtain a bFGF-incorporated gelatin hydrogel. The hydrogel sheet thus prepared was rectangular (1 x 10 mm) and had a thickness of 0.7 mm. The moisture content of the corresponding hydrogel sheet was 95%. All experimental procedures were carried out under sterile conditions.

[0082] (ii) Animal experiments

[0083] Eight beagle dogs weighing 10kg-12kg were orally intubated with ether anesthetized and a midline sternotomy was performed in the ...

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Abstract

There are disclosed a method to enhance sternal treatment after sternotomy with or without removal of at least one of thoracic arteries which comprises applying an agent for the treatment of sternum after sternotomy to or at around the sternum, wherein the agent comprises at least one selected from the group consisting of an angiogenetic factor, an osteogenetic factor and their analogues such as bFGF, aFGF, TGF beta, VEGF, HGF, BMP, PDGF, TGF alpha, other cytokines or gene as an effective ingredient and an agent to be used for the method; and an agent to enhance healing of or treating sternum after sternotomy comprising the same.

Description

field of invention [0001] The present invention relates to a method of promoting sternal healing following a sternotomy (i.e., an incision of the sternum proximal to the heart) in procedures such as open-heart surgery or coronary artery surgery using agents containing angiogenic factors, said The sternotomy includes removal of at least one internal thoracic artery (hereinafter sometimes referred to as "ITA"). Background technique [0002] In most cases, sternotomy remains essential in the operation of various heart diseases such as coronary heart disease, including myocardial infarction and its artificially induced complications, cardiac Valvular disease, aortic disease and congenital heart disease. However, it takes time for the sternum to heal and sometimes does not heal adequately. [0003] Slow or poor union of the sternum is one of the challenges in cardiac surgery after sternotomy. Slow healing prolongs a patient's hospital stay and significantly increases healthcar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K38/18A61K38/19A61K38/22A61K47/42A61P19/00A61P41/00
CPCA61K38/1825A61K9/00A61P19/00A61P41/00A61K38/18
Inventor 米田正始田畑泰彦
Owner KAKEN PHARMA CO LTD
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