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Method for preparing composite membrane for conducting tissue regeneration

A composite membrane and nanotechnology, applied in the field of bioengineering, can solve the problems of brittle mineralized collagen, expensive collagen membrane, inconvenient surgical operation, etc., and achieve the effect of excellent biocompatibility

Inactive Publication Date: 2005-08-31
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Collagen membrane is expensive, mineralized collagen is brittle, and surgical operation is inconvenient; polymer biocompatibility is not as good as collagen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1. Polylactic acid-glycolic acid (the mass ratio of polylactic acid and polyglycolic acid is 50 / 50) and chloroform is made into a solution that 1 liter of chloroform dissolves 100 grams of polylactic acid-glycolic acid. Stir for 5 hours and let stand for 5 hours.

[0016] 2. Add nanocrystalline hydroxyapatite / collagen to the solution in 1, wherein the mass ratio of polylactic acid-glycolic acid to nanocrystalline hydroxyapatite / collagen is 2:1, stir for 6 hours, and let stand for 6 hours to remove air bubbles .

[0017] 3. Add the solution in 2 dropwise to the polytetrafluoroethylene mold, clamp the mold to the glue homogenizer, adjust the rotation speed to 1,000 rpm, and the rotation time to 6 seconds.

[0018] 4. Place the membrane obtained in 3 at -4°C, and remove the membrane after 72 hours.

Embodiment 2

[0020] 1. Polylactic acid-glycolic acid (the mass ratio of polylactic acid and polyglycolic acid is 90 / 10) and 1,4-dioxane to form a concentration of 1 liter of 1,4-dioxane to dissolve 120 grams of polylactic acid - A solution of glycolic acid. Stir for 24 hours and let stand for 8 hours.

[0021] 2. Add nanocrystalline hydroxyapatite / collagen to the solution in 1, wherein the mass ratio of polylactic acid-glycolic acid to nanocrystalline hydroxyapatite / collagen is 2:1, stir for 10 hours, and let stand for 5 hours to remove air bubbles .

[0022] 3. Add the solution in 2 dropwise to the polytetrafluoroethylene mold, clamp the mold to the glue homogenizer, adjust the rotation speed to 2,000 rpm, and the rotation time to 9 seconds.

[0023] 4. Place the membrane obtained in 3 at 25 degrees Celsius, and remove the membrane after 48 hours.

Embodiment 3

[0025] 1. Polylactic acid-glycolic acid (the mass ratio of polylactic acid and polyglycolic acid is 60 / 40) and chloroform are made into a solution that 1 liter of chloroform dissolves 200 grams of polylactic acid-glycolic acid. Stir for 12 hours and let stand for 6 hours.

[0026] 2. Add nanocrystalline hydroxyapatite / collagen to the solution in 1, wherein the mass ratio of polylactic acid-glycolic acid to nanocrystalline hydroxyapatite / collagen is 3:1, stir for 4 hours, and let stand for 5 hours to remove air bubbles .

[0027] 3. Slowly pour the solution in 1 onto a glass plate and let it stand at 15 degrees Celsius for 60 hours.

[0028] 4. Slowly pour the solution in 2 onto the polylactic acid-glycolic acid membrane in 3. The volume ratio of the second pouring to the first volume is 1:1.

[0029] 5. Place the membrane obtained in 4 at 25 degrees Celsius, and remove the membrane after 48 hours.

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PUM

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Abstract

The invention provides a method to prepare nano-crystal hydroxylapatite / collagen / poly(lactic acid-hydroxy-acetic acid) composite film material used to guide tissue regeneration. It dissolves poly(lactic acid-hydroxy-acetic acid) in solvent to mix with nano-crystal hydroxylapatite / collagen evenly, to prepare the compound film material by suspended smearing. Its advantage: the film has excellent biocompatibility, one surface rough and the other smooth, and the film's degrading rate, thickness, and mechanical property are all adjustable.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and in particular provides a method for preparing a nanocrystalline hydroxyapatite / collagen / polylactic acid-glycolic acid composite film for guiding tissue regeneration. Background technique [0002] Guiding the research and development of tissue regeneration materials has indicated the direction of efforts of a large number of scientists in the field of biomedical engineering. Guided tissue regeneration membranes can be divided into two categories: nonabsorbable and absorbable, both of which have similar histological and clinical results as mechanical isolation barriers. However, any non-absorbable membrane is also quite technically sensitive in operation, and requires a second operation to remove it, which not only increases the pain of the patient, but also has the possibility of postoperative bacterial infection. In addition, it is difficult for nonabsorbable films to compound some in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12
Inventor 崔福斋范俊冯庆玲崔凯廖素三
Owner TSINGHUA UNIV
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