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Treatment of inflammatory disorders of the bowel and urinary bladder

A technology for inflammation, disorders, applied in the field of treatment of inflammatory disorders of the bowel and bladder

Inactive Publication Date: 2005-12-07
THERAKOS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the results observed in patients undergoing transplant surgery did not correlate with photoablation treatment efficacy, as common infection events were recorded including those patients who received extensive treatment to prevent rejection of the transplanted organ

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Patients with ulcerative conjunctivitis treated with extracorporeal photochemotherapy.

[0052] I. Patient Population Description

[0053] Patients suffering from acute ulcerative colitis were the subjects of this clinical study. To qualify for this study plan, the following inclusion / exclusion criteria must be met:

[0054] - Patient must be 40 kg

[0055] - Female patients who are due to deliver must have a pregnancy urine test within 24 hours of study treatment. Effective birth control must be administered from one month prior to study treatment to the end of the program. Female patients cannot be lactating.

[0056] —Experimental value before the study:

[0057] ●WBC over 3.0 cmm

[0058] ●hemoglobin over 6.5mg / dL

[0059] ●Platelet count >75,000 / UL

[0060] ●The prothrombin time does not exceed the normal range of 3 seconds

[0061] — can provide informed consent

[0062] - Adequate venous access

[0063] - Able and willing to comply with research protoc...

Embodiment 2

[0175] Extracorporeal photochemotherapy in patients with Crohn's disease

[0176] I. Patient Population Description

[0177] Patients with acute Crohn's disease were the subjects of this clinical study. To qualify for this study plan, the following inclusion / exclusion criteria must be met:

[0178] A. Contains Standards

[0179] - Between the ages of 18 and 65

[0180] — Diagnosis of Crohn's disease based on Malchow's criteria and Crohn's activity index (CDAI)

[0181] - Radiographic and / or endoscopic and / or sonograph positioning records within 12 months prior to study start

[0182] - Steroid-dependent disorders must be documented on at least 10 mg prednisone daily for at least three months to achieve symptom remission (remission is defined as CDAI < 200 for two consecutive weeks). Steroid dependence must be confirmed by a history of at least one relapse in the event of an attempt to reduce the steroid dose to <10 mg.

[0183] - Satisfaction in writing or orally, with a...

Embodiment 3

[0258] Extracorporeal photochemical therapy for patients with interstitial cystitis

[0259] I. Patient Population Description

[0260] Patients suffering from acute interstitial cystitis were the subjects of this clinical study. To qualify for this study plan, the following inclusion / exclusion criteria must be met:

[0261] A. Contains Standards

[0262] - aged between 18 and 65

[0263] - Satisfaction in writing or orally, with a witness, after the patient has been fully informed by the treating physician

[0264] - Before starting treatment, all women of childbearing age must undergo a documented intrarectal β-HCG pregnancy test within 24 hours of the first treatment. In addition, they had to agree to receive an adequate form of contraception in the study.

[0265] - No known allergy to heparin or 8-methoxypsoralen.

[0266] - Patient must feel pain when the bladder is full and relief when it is empty

[0267] -and-

[0268] Patient must have suprapubic, pelvic, ure...

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Abstract

Disclosed herein are methods of treating intestinal inflammatory disorders and bladder inflammatory disorders, and also methods of modulating the function of monocytes. The method involves treating the patient's blood with a photoactivatable compound, activating the photoactivatable compound with ultraviolet light, and returning the thus treated blood to the patient in a process known as extracorporeal photoremoval.

Description

Background of the invention [0001] Extracorporeal photopheresis (photopheresis) is a procedure in which 8-methoxypsoralen (8-MOP), a natural photosensitive compound, is given orally two hours before treatment; blood is then drawn from the patient, anticoagulated, and centrifuged Leukocytes were separated, and the leukocyte-enriched layer was collected. These leukocyte-containing 8-methoxypsoralen are then irradiated with ultraviolet-A light (UVA), allowing 8-MOP to bind to pyrimidine bases in DNA and intracellular and extracellular proteins. These processed leukocytes are then returned to the patient, and the result is an immune modulator that has been found to have positive clinical effects in a variety of diseases [Edelson RL. Photoablation: a clinically relevant modulator of the immune-biological response. [Review] Ann NY Acad Sci. 191;636:154-64]. [0002] A large number of diseases are believed to be primarily associated with or mediated by T-cells. Some diseases such ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/37A61M1/36
CPCA61K31/37A61M2202/0439A61M2001/3683A61M2205/051A61M1/3681A61M1/3683A61P1/00A61P1/04A61P13/10A61P29/00A61P37/02A61M2202/0092A61M37/00
Inventor J·泽尔迪斯S·麦克劳克林B·斯托奇R·克诺布勒
Owner THERAKOS INC