The invention belongs to the field of cosmetics, and particularly relates to a traditional Chinese medicine sterilization hand cream which comprises the following components by weight percent: 20-25% of Chinese herbal medicinal ingredient, 10-20% of glycerol, 3-5% of vegetable oil, 0.1-0.3% of vitamin E, 0.5-0.8% of safflower seed oil, 0.2-0.5% of benzyl alcohol, 0.2-0.5% of cetearyl alcohol, 0.2-0.5% of collagen, 0.2-0.5% of squalane, 0.2-0.5% of honey, 0.5-2% of triethanolamine, 0.2-0.5% of shea butter, 0.2-0.5% of essence and the balance of medical Vaseline. The traditional Chinese medicine sterilization hand cream can be used for effectively supplementing water for hands, preventing peeling and cracking, protecting the dry hand skin, is fresh and cool in character, can rapidly permeate, and enables the skin to be smooth and nourished; and the hands can be instantaneously moisturized and smell perfect.