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Hypotensor composition, prepn. method and application thereof

A composition and technology for lowering blood pressure, applied in the directions of drug combination, cardiovascular system diseases, sulfur/selenium/tellurium active ingredients, etc., can solve the problems of cyanide accumulation, easy decomposition, lactic acidosis, etc., and achieve rapid blood pressure reduction. , low price, less side effects

Inactive Publication Date: 2005-12-28
SHANXI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of rapid blood pressure reduction, sometimes the adverse reactions of drugs can offset the benefits of blood pressure reduction. For example, hydralazine can reflexively increase heart rate and cardiac output, which can cause palpitations, angina pectoris, and even myocardial infarction.
Another example is sodium nitroprusside (sodium nitroprusside), one of the most commonly used drugs for cardiovascular emergencies. It has strong effects and quick onset, can expand the arterial and venous systems in a balanced manner, and has a definite antihypertensive effect. Decomposition, the second is that long-term use can produce cyanide accumulation, leading to lactic acidosis, and the third is that its intermediate metabolites need to be converted into thiocyanate and then excreted from the kidneys, so it must be used with caution in liver and kidney insufficiency and heart failure
[0004] Table 1 lists common drugs for emergency treatment of hypertension, but each drug has certain side effects

Method used

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  • Hypotensor composition, prepn. method and application thereof
  • Hypotensor composition, prepn. method and application thereof
  • Hypotensor composition, prepn. method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, the preparation of hypotensive composition

[0030] Solution A: [Na 2 SO 3 ]0.09mol / L, [NaHSO 3 ] 0.03mol / L. Weigh Na 2 SO 3 0.5671g, NaHSO 3 0.1561g, after mixing, dissolve with physiological saline and dilute to 50ml. Na 2 SO 3 and NaHSO 3 The ratio of the two is 3:1 (molar ratio), pH7.104. The composition is divided into clean and sterilized glass containers, sealed for later use. Equivalent to 45.36mgNa after injection into rats 2 SO 3 / kg body weight and 12.48mg NaHSO 3 / kg body weight.

[0031] Solution B: [Na 2 SO 3 ]0.135mol / L, [NaHSO 3 ] 0.045mol / L. Weigh Na 2 SO 3 0.8507g, NaHSO 3 0.2341g, after mixing, dissolve with physiological saline and dilute to 50ml. Na 2 SO 3 and NaHSO 3 The ratio of the two is 3:1 (molar ratio), pH7.041. The composition is divided into clean and sterilized glass containers, sealed for later use. Equivalent to 68.04mgNa after injection into rats 2 SO 3 / kg body weight and 18.32mg NaHSO 3 / kg ...

Embodiment 2

[0034] Embodiment 2, the animal experiment of antihypertensive composition

[0035] (1) The composition prepared in Example 1 was taken for animal experiments.

[0036] (2) Experimental animals: Wistar rats were purchased from the animal room of Shanxi Provincial Institute of Traditional Chinese Medicine, aged 7-8 weeks, and weighing 180-200 g.

[0037] (3) Blood pressure measuring instrument: The RBP-1 rat blood pressure measuring instrument produced by the China-Japan Friendship Institute of Clinical Medicine was used to measure the systolic pressure of the rat tail artery. The pressure measurement was repeated 6 times during the measurement, and the mean value of the 6 times was used as the tail systolic blood pressure of each rat.

[0038] (4) Determination steps: Rats are bought back and fed in the laboratory animal room, free to eat and drink, and measure blood pressure once a day in the morning and afternoon, one is to make these rats adapt to the measurement environme...

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Abstract

A blood pressure lowering composition is characterized in that sodium sulfite (Na 2 SO 3 ) and sodium bisulfite (NaHSO 3 )constitute. The composition is to use physiological saline as a solvent (also can directly use double distilled water or distilled water as a solvent), Na 2 SO 3 and NaHSO 3 It is formulated by mixing at a molar ratio of 4:1-2:1. The composition can be used as a medicine for treating hypertensive pain, and has the characteristics of rapid blood pressure reduction, few side effects, simple production process and low price.

Description

1. Technical field [0001] The invention relates to a drug for lowering blood pressure, in particular to a composition with the effect of rapidly lowering blood pressure, a preparation method and application thereof. 2. Background technology [0002] Hypertension is a common disease that endangers public health. The etiology is complex and there are individual factors. Rational medication should be taken according to the condition. At present, there are many kinds of antihypertensive drugs, which can be divided into the following eight categories according to their action sites and mechanisms (see Table 1): (1) diuretic antihypertensive drugs; (2) β-adrenoceptor blocking drugs; (3) Vasodilators; (4) calcium channel blockers; (5) angiotensin-converting enzyme inhibitors; (6) central nervous system and sympathetic nerve inhibitors; (7) enzyme inhibitors; (8) angiotensin II receptors body antagonists. [0003] In the course of hypertension, a sudden or significant increase in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/04A61P9/12
Inventor 孟紫强耿红白巨利张健彪张欣
Owner SHANXI UNIV