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Preparing magnetic high molecular microball by compound emulsion method

A polymer microsphere and magnetic technology, applied in the field of magnetic polymer microspheres and their preparation, can solve problems such as limiting the application of magnetic polymer microspheres

Inactive Publication Date: 2006-09-20
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through the introduction of the existing preparation methods above, it is not difficult to see that the microspheres prepared by none of the existing methods can meet the requirements of ideal microspheres, which also limits the application of magnetic polymer microspheres in medical and biological separation. Applications

Method used

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  • Preparing magnetic high molecular microball by compound emulsion method
  • Preparing magnetic high molecular microball by compound emulsion method
  • Preparing magnetic high molecular microball by compound emulsion method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 0.9 g of PSt (polystyrene) and 2.0 g of Span85 (sorbitan trioleate), dissolve them in 40 ml of toluene to form an oil phase O, and then divide it into two parts. Add W in one copy 11 (0.1ml of FeCl with a concentration of 0.50mol / l 3 Aqueous solution and 0.2ml of FeCl with a concentration of 0.50mol / l 2 Aqueous solution), another part added W 12 (0.3 ml of an aqueous NaOH solution having a concentration of 2.0 mol / l). Stir for a certain period of time with an emulsifying homogenizer respectively, and the rotating speed is 9000 rpm, and then the two parts of emulsion are mixed evenly to form stable composite colostrum (W 11 +W 12 ) / O. Prepare the external water phase W 2 (H 2 (225g, polyvinyl alcohol 1.5g), the outer aqueous phase W 2 Stir with a stirring paddle at a speed of 400 rpm. The prepared compound colostrum (W 11 +W 12 ) / O is slowly poured into the stirring external water phase to form double emulsion (W 11 +W 12 ) / O / W 2 , continue to stir for...

Embodiment 2

[0040] Take 0.9g of PSt (polystyrene) and 2.6g of Arace183 (sorbitan sesquioleate), dissolve in 40ml of dichloromethane (DCM) to form oil phase O, and then divide it into two parts. Add W in one copy 11 (0.1ml of CoCl with a concentration of 2.0mol / l 2 Aqueous solution and 0.1ml of FeCl with a concentration of 2.0mol / l 2 Aqueous solution and 0.2ml of FeCl with a concentration of 0.2mol / l 3 Aqueous solution), another part added W 12 (0.4 ml of an aqueous NaOH solution with a concentration of 6.0 mol / l). They were emulsified for a certain period of time by ultrasonic emulsification. Mix the two emulsions evenly to form a compound colostrum (W 11 +W 12 ) / O. Prepare the external water phase W 2 (H 2 (225g, polyvinyl alcohol 1.5g), the outer aqueous phase is stirred with a stirring blade, and the rotating speed is 500 rev / min. The prepared compound colostrum (W 11 +W 12 ) / O is slowly poured into the stirring external water phase to form double emulsion (W 11 +W 12 ) / O...

Embodiment 3

[0042] Take 0.6g of St (styrene) and HEMA (2-hydroxyethyl methacrylate) copolymer (9:1 ratio) and 2.4g of HCO10 (polyoxyethylene 10 hydrogenated castor oil), then add 23ml Toluene and 17 ml of dichloromethane (DCM) were stirred for 2 hrs to form an oily phase O, which was then divided into two portions. Add W in one copy 11 (0.10ml of Fe with a concentration of 0.52mol / l 2 (SO 4 ) 3 Aqueous solution and 0.10ml of FeSO with a concentration of 0.52mol / l 4 Aqueous solution and 0.2 mol / l concentration of 0.26 mol / l MgCl 2 Aqueous solution), another part added W 12 (0.4 ml of an aqueous NaOH solution with a concentration of 6 mol / l). Emulsify with a homogeneous emulsifier for a certain period of time, and the rotating speed is 7500 rpm, then emulsify for a certain period of time with ultrasonic emulsification, then mix the two emulsions and mix them evenly to form a composite colostrum (W 11 +W 12 ) / O. Prepare the external water phase W 2 (H 2 (225g, polyvinyl alcohol 1....

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Abstract

Magnetic high molecular microballoon is prepared through compound emulsifying process and has embedded magnetic grains accounting for 1-50 wt% of the microballoon, stable chemical property and acid and alkali resistance. The preparation process includes preparing two kinds of initial emulsion, mixing the two kinds of initial emulsion, compound emulsification, eliminating solvent, washing magnetic microballoon, and other steps. The present invention features the simultaneous generation and embedding of the magnetic grains. The microballoon size and magnetic grain content may be controlled. The magnetic microballoon may be used as carrier of enzyme, antibody and medicine in cell separate, clinical diagnosis, etc. The present invention has the features of simple process, high repeatability, low cost, etc.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to magnetic polymer microspheres with magnetism and a preparation method thereof. technical background [0002] Magnetic polymer microspheres refer to embedding magnetic particles in polymer microspheres by appropriate methods to form microspheres with certain magnetic responsiveness and special structure. It is a new type of functional polymer composite material developed in the late 1970s. On the one hand, it has the characteristics of polymer microspheres. Through chemical reactions such as copolymerization and surface modification, the surface of polymer microspheres can be equipped with a variety of functional groups, so that it can bind a variety of biologically active substances; on the other hand, it It is also magnetic, and can be quickly separated from other non-magnetic substances under an external magnetic field, and the energy consumption is small...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08K3/22
Inventor 马光辉苏志国杨建
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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